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  4. SPATA13 Antibody

SPATA13 Antibody

  • 中文名稱：
    SPATA13兔多克隆抗體
  • 貨號：
    CSB-PA022491GA01HU
  • 規(guī)格：
    ￥3,900
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
  • 別名：
    APC-stimulated guanine nucleotide exchange factor 2 antibody; ARHGEF29 antibody; Asef2 antibody; FLJ31208 antibody; RP11-307N16.3 antibody; Spata13 antibody; Spermatogenesis-associated protein 13 antibody; SPT13_HUMAN antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human,Mouse,Rat
  • 免疫原：
    Human SPATA13
  • 免疫原種屬：
    Homo sapiens (Human)
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA,WB,IF
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    Acts as guanine nucleotide exchange factor (GEF) for RHOA, RAC1 and CDC42 GTPases. Regulates cell migration and adhesion assembly and disassembly through a RAC1, PI3K, RHOA and AKT1-dependent mechanism. Increases both RAC1 and CDC42 activity, but decreases the amount of active RHOA. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Involved in tumor angiogenesis and may play a role in intestinal adenoma formation and tumor progression.
  • 基因功能參考文獻(xiàn)：
    1. Phosphorylation of S106 modulates Asef2 guanine nucleotide exchange factor activity and Asef2-mediated cell migration and adhesion turnover. PMID: 24874604
    2. A new role for Rac activation, promoted by Asef2, in modulating actomyosin contractility. PMID: 24144700
    3. Asef2 activates Rac1 to modulate adhesion and actin dynamics and thereby regulate cell migration. PMID: 19934221
    4. These results suggest that similar to Asef, Asef2 plays an important role in cell migration, and that Asef2 activated by truncated mutant APC is required for aberrant migration of colorectal tumor cells. PMID: 17599059
    5. Asef2, Neurabin2 and APC cooperatively regulate actin cytoskeletal organization and are required for HGF-induced cell migration. PMID: 19151759
    6. Observational study of gene-disease association. (HuGE Navigator) PMID: 19910543

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  • 亞細(xì)胞定位：
    Cytoplasm. Cell projection, filopodium. Cell projection, lamellipodium. Cell projection, ruffle membrane. Note=Accumulates in the lamellipodium and ruffle membrane in response to hepatocyte growth factor (HGF) treatment.
  • 組織特異性：
    Expressed at high levels in the placenta, spleen and kidney, at moderate levels in lung, small intestine, liver, brain and heart, and at low levels in skeletal muscle. Expression is aberrantly enhanced in most colorectal tumors.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 23222

    OMIM: 613324

    KEGG: hsa:221178

    STRING: 9606.ENSP00000371542

    UniGene: Hs.434298



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