在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. SORD Antibody, FITC conjugated

SORD Antibody, FITC conjugated

  • 中文名稱：
    SORD兔多克隆抗體, FITC偶聯
  • 貨號：
    CSB-PA022410HC01HU
  • 規格：
    ￥880
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) SORD Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    SORD
  • 別名：
    DHSO_HUMAN antibody; L iditol 2 dehydrogenase antibody; L-iditol 2-dehydrogenase antibody; OTTHUMP00000161939 antibody; SDH antibody; Sorbitol dehydrogenase 1 antibody; Sorbitol dehydrogenase antibody; SORD 1 antibody; SORD antibody; SORD1 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Sorbitol dehydrogenase protein (201-357AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    FITC
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式：
    Liquid
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Polyol dehydrogenase that catalyzes the reversible NAD(+)-dependent oxidation of various sugar alcohols. Is mostly active with D-sorbitol (D-glucitol), L-threitol, xylitol and ribitol as substrates, leading to the C2-oxidized products D-fructose, L-erythrulose, D-xylulose, and D-ribulose, respectively. Is a key enzyme in the polyol pathway that interconverts glucose and fructose via sorbitol, which constitutes an important alternate route for glucose metabolism. The polyol pathway is believed to be involved in the etiology of diabetic complications, such as diabetic neuropathy and retinopathy, induced by hyperglycemia. May play a role in sperm motility by using sorbitol as an alternative energy source for sperm motility. May have a more general function in the metabolism of secondary alcohols since it also catalyzes the stereospecific oxidation of (2R,3R)-2,3-butanediol. To a lesser extent, can also oxidize L-arabinitol, galactitol and D-mannitol and glycerol in vitro. Oxidizes neither ethanol nor other primary alcohols. Cannot use NADP(+) as the electron acceptor.
  • 基因功能參考文獻：
    1. SDH gene expression was increased by hypoxia and oxidative stress, but not extracellular hyperosmolarity. Hyperosmolarity and hypoxia did not alter the SDH protein level. PMID: 27628063
    2. One of the most striking changes involved sorbitol dehydrogenase, a key enzyme in the polyol pathway. Validation studies revealed dramatically increased sorbitol dehydrogenase concentrations and activity in adenomas and cancer cell lines, along with important changes in the expression of other enzymes in the same (AKR1B1) and related (KHK) pathways. PMID: 24567419
    3. The SDH level was significantly decreased in patients with proliferative compared with non-proliferative retinopathy in both insulin and oral diabetic groups. PMID: 23452182
    4. Thus, our findings suggest that the -888G > C polymorphism in the SORD gene is not involved in the pathogenesis of diabtic retinopathy in type 2 diabetes. PMID: 23850972
    5. The expression of SORD is regulated by androgens in human prostate. In prostate cancer, increased immunostaining was associated with high Gleason patterns and high serum PSA concentrations. PMID: 20372835
    6. crystals of sorbitol dehydrogenase belong to the monoclinic C2 space group, with unit-cell parameters a = 145.9, b = 52.3, c = 169.0 A, beta = 101.8 degrees PMID: 12595725
    7. Sorbitol dehydrogenase (SDH), a member of the medium-chain dehydrogenase/reductase protein family and the second enzyme of the polyol pathway of glucose metabolism, converts sorbitol to fructose strictly using NAD(+) as coenzyme. PMID: 14965227
    8. Results compare the catalytic mechanism of liver sorbitol dehydrogenase with wild-type and Glu154-->Cys forms of yeast xylitol dehydrogenase. PMID: 17343568
    9. The zinc-finger protein ZAC1 is up-regulated under hypertonic stress and negatively regulates expression of sorbitol dehydrogenase, allowing for accumulation of sorbitol as a compatible organic osmolyte. PMID: 19423711

    顯示更多

    收起更多

  • 亞細胞定位：
    Mitochondrion membrane; Peripheral membrane protein. Cell projection, cilium, flagellum.
  • 蛋白家族：
    Zinc-containing alcohol dehydrogenase family
  • 組織特異性：
    Expressed in liver. Expressed in kidney and epithelial cells of both benign and malignant prostate tissue. Expressed in epididymis (at protein level).
  • 數據庫鏈接：

    HGNC: 11184

    OMIM: 182500

    KEGG: hsa:6652

    STRING: 9606.ENSP00000267814

    UniGene: Hs.878



主站蜘蛛池模板： 国产女人乱人伦精品一区二区| 西西人体大胆啪啪实拍| 亚洲欧美日韩_欧洲日韩| 好男人社区影院www| 亚洲精品无码不卡在线播he| 久久无码av中文出轨人妻| 色天使亚洲综合一区二区| 亚洲午夜未满十八勿入| 国产猛烈高潮尖叫视频免费| 亚洲欧美日本韩国| 秋霞最新高清无码鲁丝片| 老熟女老太婆爽| 亚洲中文字幕无码久久2017| 国产无套内射又大又猛又粗又爽| 亚洲精品日韩一区二区小说| 久久精品亚洲中文字幕无码麻豆| 亚洲精品一区二区久久| 人妻洗澡被强公日日澡电影| 欧美成人一卡二卡三卡四卡| 日本一区二区三区免费播放| 国产精品久久国产精品99 gif| 日韩人妻无码精品一专区| 国内高清a自拍视频| 朝鲜女人大白屁股ass孕交| 国产成人无码精品午夜福利a | 国产成人无码a区视频| 久久青草成人综合网站| 欧美人与性动交g欧美精器| 最新精品国偷自产在线| 久久本色成人综合网| 综合偷自拍亚洲乱中文字幕 | 午夜亚洲精品久久一区二区| 国产女人被狂躁到高潮小说| 日本熟妇人妻xxxxx人hd| 69堂人成无码免费视频果冻传媒 | 久久精品超碰av无码| 九九久久精品无码专区| 人妻无码中文字幕一区二区三区| 国产在线高清视频无码| 一本一道波多野结衣av中文| 欧美色就是色|