在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. SORD Antibody, Biotin conjugated

SORD Antibody, Biotin conjugated

  • 中文名稱：
    SORD兔多克隆抗體, Biotin偶聯(lián)
  • 貨號：
    CSB-PA022410HD01HU
  • 規(guī)格：
    ￥880
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) SORD Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    SORD
  • 別名：
    DHSO_HUMAN antibody; L iditol 2 dehydrogenase antibody; L-iditol 2-dehydrogenase antibody; OTTHUMP00000161939 antibody; SDH antibody; Sorbitol dehydrogenase 1 antibody; Sorbitol dehydrogenase antibody; SORD 1 antibody; SORD antibody; SORD1 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human Sorbitol dehydrogenase protein (201-357AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Biotin
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點(diǎn)詳情

  • 功能：
    Polyol dehydrogenase that catalyzes the reversible NAD(+)-dependent oxidation of various sugar alcohols. Is mostly active with D-sorbitol (D-glucitol), L-threitol, xylitol and ribitol as substrates, leading to the C2-oxidized products D-fructose, L-erythrulose, D-xylulose, and D-ribulose, respectively. Is a key enzyme in the polyol pathway that interconverts glucose and fructose via sorbitol, which constitutes an important alternate route for glucose metabolism. The polyol pathway is believed to be involved in the etiology of diabetic complications, such as diabetic neuropathy and retinopathy, induced by hyperglycemia. May play a role in sperm motility by using sorbitol as an alternative energy source for sperm motility. May have a more general function in the metabolism of secondary alcohols since it also catalyzes the stereospecific oxidation of (2R,3R)-2,3-butanediol. To a lesser extent, can also oxidize L-arabinitol, galactitol and D-mannitol and glycerol in vitro. Oxidizes neither ethanol nor other primary alcohols. Cannot use NADP(+) as the electron acceptor.
  • 基因功能參考文獻(xiàn)：
    1. SDH gene expression was increased by hypoxia and oxidative stress, but not extracellular hyperosmolarity. Hyperosmolarity and hypoxia did not alter the SDH protein level. PMID: 27628063
    2. One of the most striking changes involved sorbitol dehydrogenase, a key enzyme in the polyol pathway. Validation studies revealed dramatically increased sorbitol dehydrogenase concentrations and activity in adenomas and cancer cell lines, along with important changes in the expression of other enzymes in the same (AKR1B1) and related (KHK) pathways. PMID: 24567419
    3. The SDH level was significantly decreased in patients with proliferative compared with non-proliferative retinopathy in both insulin and oral diabetic groups. PMID: 23452182
    4. Thus, our findings suggest that the -888G > C polymorphism in the SORD gene is not involved in the pathogenesis of diabtic retinopathy in type 2 diabetes. PMID: 23850972
    5. The expression of SORD is regulated by androgens in human prostate. In prostate cancer, increased immunostaining was associated with high Gleason patterns and high serum PSA concentrations. PMID: 20372835
    6. crystals of sorbitol dehydrogenase belong to the monoclinic C2 space group, with unit-cell parameters a = 145.9, b = 52.3, c = 169.0 A, beta = 101.8 degrees PMID: 12595725
    7. Sorbitol dehydrogenase (SDH), a member of the medium-chain dehydrogenase/reductase protein family and the second enzyme of the polyol pathway of glucose metabolism, converts sorbitol to fructose strictly using NAD(+) as coenzyme. PMID: 14965227
    8. Results compare the catalytic mechanism of liver sorbitol dehydrogenase with wild-type and Glu154-->Cys forms of yeast xylitol dehydrogenase. PMID: 17343568
    9. The zinc-finger protein ZAC1 is up-regulated under hypertonic stress and negatively regulates expression of sorbitol dehydrogenase, allowing for accumulation of sorbitol as a compatible organic osmolyte. PMID: 19423711

    顯示更多

    收起更多

  • 亞細(xì)胞定位：
    Mitochondrion membrane; Peripheral membrane protein. Cell projection, cilium, flagellum.
  • 蛋白家族：
    Zinc-containing alcohol dehydrogenase family
  • 組織特異性：
    Expressed in liver. Expressed in kidney and epithelial cells of both benign and malignant prostate tissue. Expressed in epididymis (at protein level).
  • 數(shù)據(jù)庫鏈接：

    HGNC: 11184

    OMIM: 182500

    KEGG: hsa:6652

    STRING: 9606.ENSP00000267814

    UniGene: Hs.878



主站蜘蛛池模板： 欧美人与动牲交a欧美| 亚洲国产精品综合久久20| 亚洲日韩乱码一区二区三区四区| 久久先锋男人av资源网站| 亚洲制服有码在线丝袜| 国产精品卡一卡2卡三卡网站| 少妇被粗大的猛烈进出视频| 国色天香成人网| 日韩少妇白浆无码系列| 又粗又黄又爽视频免费看 | 少妇放荡的呻吟干柴烈火免费视频| 99热久久这里只有精品| 性欧美俄罗斯极品| 久久天天躁狠狠躁夜夜爽| 青青久在线视频免费观看| 国产xxxx做受性欧美88| 久久毛片免费看一区二区三区 | 欧美亚洲色aⅴ大片| 乱码国产丰满人妻www| 精品无码午夜福利理论片| 伊人久久大香线蕉avapp下载| 国产成+人+综合+亚洲欧美| 国产欧美一区二区三区免费视频 | 亚洲熟女www一区二区三区| 黑人好猛厉害爽受不了好大撑| 国产又粗又猛又爽的视频a片| 永久免费看啪啪网址入口| 成年丰满熟妇午夜免费视频| 老司机导航亚洲精品导航| 国产亚洲人成网站在线观看| 影视先锋av资源噜噜| 国产精品多p对白交换绿帽| 丁香狠狠色婷婷久久综合| 亚洲五月丁香综合视频| 美女张开腿让人桶| 亚洲性人人天天夜夜摸18禁止| 婷婷射精av这里只有精品| 熟女少妇内射日韩亚洲| 久久精品囯产精品亚洲| 成人国内精品久久久久一区| 欧美xxxx黑人又粗又长精品|