在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

SORCS2 Antibody, HRP conjugated

  • 中文名稱:
    SORCS2兔多克隆抗體, HRP偶聯
  • 貨號:
    CSB-PA822282LB01HU
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) SORCS2 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    SORCS2
  • 別名:
    SORCS2 antibody; KIAA1329 antibody; VPS10 domain-containing receptor SorCS2 [Cleaved into: SorCS2 122 kDa chain; SorCS2 104 kDa chain; SorCS2 18 kDa chain] antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human VPS10 domain-containing receptor SorCS2 protein (712-786AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    HRP
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    The heterodimer formed by NGFR and SORCS2 functions as receptor for the precursor forms of NGF (proNGF) and BDNF (proBDNF). ProNGF and proBDNF binding both promote axon growth cone collapse (in vitro). Plays a role in the regulation of dendritic spine density in hippocampus neurons. Required for normal neurite branching and extension in response to BDNF. Plays a role in BDNF-dependent hippocampal synaptic plasticity. Together with NGFR and NTRK2, is required both for BDNF-mediated synaptic long-term depression and long-term potentiation. ProNGF binding promotes dissociation of TRIO from the heterodimer, which leads to inactivation of RAC1 and/or RAC2 and subsequent reorganization of the actin cytoskeleton. Together with the retromer complex subunit VPS35, required for normal expression of GRIN2A at synapses and dendritic cell membranes. Required for normal expression of the amino acid transporter SLC1A1 at the cell membrane, and thereby contributes to protect cells against oxidative stress.; Does not promote Schwann cell apoptosis in response to proBDNF.; SorCS2 104 kDa chain and SorCS2 18 kDa chain together promote Schwann cell apoptosis in response to proBDNF.
  • 基因功能參考文獻:
    1. Here the authors have characterized SorCS1, SorCS2 and SorCS3 using biochemical methods and electron microscopy. They found that their purified extracellular domains co-exist in stable dimeric and monomeric populations. PMID: 28827148
    2. Sortilin-related receptor CNS expressed 2 (SorCS2) is one of the vacuolar protein sorting 10 family proteins which may be involved in the disease process of amyotrophic lateral sclerosis PMID: 26420026
  • 亞細胞定位:
    Cell membrane; Single-pass type I membrane protein. Cell projection. Cytoplasmic vesicle membrane; Single-pass type I membrane protein. Early endosome membrane. Recycling endosome membrane. Cell junction, synapse, synaptosome. Perikaryon. Cell projection, dendrite. Cell projection, dendritic spine. Cell junction, synapse, postsynaptic density membrane.
  • 蛋白家族:
    VPS10-related sortilin family, SORCS subfamily
  • 組織特異性:
    Detected on neurons in the caudate region. Detected on neurons in the hippocampus (at protein level). Highly expressed in brain and kidney. Detected at low levels in heart, liver, small intestine, skeletal muscle and thymus.
  • 數據庫鏈接:

    HGNC: 16698

    OMIM: 606284

    KEGG: hsa:57537

    STRING: 9606.ENSP00000422185

    UniGene: Hs.479099



主站蜘蛛池模板: 国产精品美女久久久久av爽 | 欧美人禽杂交狂配免费看| 丰满少妇被猛烈进入av久久| 插一插射一射视频| 粉嫩少妇内射浓精videos| 欧美巨大xxxx做受高清| 国产少妇高潮在线观看| 最新国产av无码专区亚洲| 久久99国产亚洲高清观看首页| 国产精久久一区二区三区| 97性无码区免费| 国产亚洲综合区成人国产系列| 国内老熟妇对白xxxxhd| 人妻少妇被粗大爽.9797pw| 99视频国产精品免费观看| 国产精品一区二区高清在线| 5566先锋影音夜色资源站在线观看| 日韩伦人妻无码| 国产高清精品软件丝瓜软件| 国产精品久久久久久52avav| 国外av无码精品国产精品| 亚洲精品白浆高清久久久久久| 少妇白浆呻吟爽| 最近中文字幕mv在线视频2018| 蜜桃臀无码内射一区二区三区| 人妻有码av中文字幕久久琪| 日产精品一区2区卡四卡二卡 | 久久综合九色综合97网| 免费播放婬乱男女婬视频国产| av制服丝袜白丝国产网站| 日韩欧美人妻一区二区三区| 高清破外女出血av毛片| 高中国产开嫩苞实拍视频在线观看| 自拍偷自拍亚洲精品情侣| 亚洲精品无码久久久久久| 亚洲综合色噜噜狠狠网站超清| 亚洲综合欧美在线一区在线播放| 未满小14洗澡无码视频网站| 免费人成在线观看网站品善网| 亚洲精品久久一区二区无卡| 日本精品aⅴ一区二区三区|