在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

SORCS2 Antibody, FITC conjugated

  • 中文名稱(chēng):
    SORCS2兔多克隆抗體, FITC偶聯(lián)
  • 貨號(hào):
    CSB-PA822282LC01HU
  • 規(guī)格:
    ¥880
  • 其他:

產(chǎn)品詳情

  • 產(chǎn)品名稱(chēng):
    Rabbit anti-Homo sapiens (Human) SORCS2 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    SORCS2
  • 別名:
    SORCS2 antibody; KIAA1329 antibody; VPS10 domain-containing receptor SorCS2 [Cleaved into: SorCS2 122 kDa chain; SorCS2 104 kDa chain; SorCS2 18 kDa chain] antibody
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human
  • 免疫原:
    Recombinant Human VPS10 domain-containing receptor SorCS2 protein (712-786AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標(biāo)記方式:
    FITC
  • 克隆類(lèi)型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式:
    Liquid
  • 儲(chǔ)存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能:
    The heterodimer formed by NGFR and SORCS2 functions as receptor for the precursor forms of NGF (proNGF) and BDNF (proBDNF). ProNGF and proBDNF binding both promote axon growth cone collapse (in vitro). Plays a role in the regulation of dendritic spine density in hippocampus neurons. Required for normal neurite branching and extension in response to BDNF. Plays a role in BDNF-dependent hippocampal synaptic plasticity. Together with NGFR and NTRK2, is required both for BDNF-mediated synaptic long-term depression and long-term potentiation. ProNGF binding promotes dissociation of TRIO from the heterodimer, which leads to inactivation of RAC1 and/or RAC2 and subsequent reorganization of the actin cytoskeleton. Together with the retromer complex subunit VPS35, required for normal expression of GRIN2A at synapses and dendritic cell membranes. Required for normal expression of the amino acid transporter SLC1A1 at the cell membrane, and thereby contributes to protect cells against oxidative stress.; Does not promote Schwann cell apoptosis in response to proBDNF.; SorCS2 104 kDa chain and SorCS2 18 kDa chain together promote Schwann cell apoptosis in response to proBDNF.
  • 基因功能參考文獻(xiàn):
    1. Here the authors have characterized SorCS1, SorCS2 and SorCS3 using biochemical methods and electron microscopy. They found that their purified extracellular domains co-exist in stable dimeric and monomeric populations. PMID: 28827148
    2. Sortilin-related receptor CNS expressed 2 (SorCS2) is one of the vacuolar protein sorting 10 family proteins which may be involved in the disease process of amyotrophic lateral sclerosis PMID: 26420026
  • 亞細(xì)胞定位:
    Cell membrane; Single-pass type I membrane protein. Cell projection. Cytoplasmic vesicle membrane; Single-pass type I membrane protein. Early endosome membrane. Recycling endosome membrane. Cell junction, synapse, synaptosome. Perikaryon. Cell projection, dendrite. Cell projection, dendritic spine. Cell junction, synapse, postsynaptic density membrane.
  • 蛋白家族:
    VPS10-related sortilin family, SORCS subfamily
  • 組織特異性:
    Detected on neurons in the caudate region. Detected on neurons in the hippocampus (at protein level). Highly expressed in brain and kidney. Detected at low levels in heart, liver, small intestine, skeletal muscle and thymus.
  • 數(shù)據(jù)庫(kù)鏈接:

    HGNC: 16698

    OMIM: 606284

    KEGG: hsa:57537

    STRING: 9606.ENSP00000422185

    UniGene: Hs.479099



主站蜘蛛池模板: 成人免费视频在线观看地区免下载| 美女扒开奶罩露出奶头视频网站 | 亚洲情a成黄在线观看| 99j久久精品久久久久久| 波多野结衣一区二区三区av高清| 国产精品videossex久久发布 | 国产av丝袜旗袍无码网站 | 国产色秀视频在线播放| 免费国产在线精品一区不卡 | 丰满白嫩人妻中出无码| 日韩免费码中文在线观看 | 好吊妞国产欧美日韩免费观看| 西西人体午夜大胆无码视频| 日本一道一区二区视频| 国产精品久久久久久麻豆一区| 免费人成无码大片在线观看| 亚洲人成网77777亚洲色| 久久国产精久久精产国| 亚洲人成无码网站在线观看| 久久婷婷大香萑太香蕉av人| 国产成人精品综合久久久久| 狠狠色狠狠色综合| 9999国产精品欧美久久久久久 | 乱人伦xxxx国语对白| 日产中文字幕在线观看| 精品人伦一区二区三电影| 国产精品高潮呻吟av久久黄| 色猫咪免费人成网站在线观看| 国产亚洲精品97在线视频一 | 色综合久久婷婷五月| 18禁黄污无遮挡无码网站| 国产成人欧美亚洲日韩电影| 国产人妻人伦精品1国产| 丰满五十六十老熟女hd| 50岁熟妇大白屁股真爽| 国产专区免费资源网站| av无码人妻中文字幕| 欧美成人精品三级一二三在线观看| 精品人妻少妇一区二区三区在线 | 爆乳熟妇一区二区三区霸乳| 久久国产精品久久精品国产|