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  4. SNX17 Antibody, Biotin conjugated

SNX17 Antibody, Biotin conjugated

  • 中文名稱：
    SNX17兔多克隆抗體, Biotin偶聯(lián)
  • 貨號(hào)：
    CSB-PA614877LD01HU
  • 規(guī)格：
    ￥880
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) SNX17 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    SNX17
  • 別名：
    Similar to a putative C elegans gene encoded in cosmid F17H10 antibody; Snx17 antibody; SNX17_HUMAN antibody; Sorting nexin 17 antibody; Sorting nexin-17 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human Sorting nexin-17 protein (280-457AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Biotin
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Critical regulator of endosomal recycling of numerous surface proteins, including integrins, signaling receptor and channels. Binds to NPxY sequences in the cytoplasmic tails of target cargos. Associates with retriever and CCC complexes to prevent lysosomal degradation and promote cell surface recycling of numerous cargos such as integrins ITGB1, ITGB5 and their associated alpha subunits. Also required for maintenance of normal cell surface levels of APP and LRP1. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)).
  • 基因功能參考文獻(xiàn)：
    1. HPV-16 L2 recruitment of SNX17 occurs prior to capsid disassembly. PMID: 28475030
    2. The double knockdown of SNX17 and SNX27 results in a striking reduction of papillomavirus 16 infection due to interruption of their binding to the L2 viral protein. PMID: 26202251
    3. SNX17 plays a role in the maintenance of normal surface levels of activating receptors and integrins to permit optimum T cell activation at the immune synapse. PMID: 25825439
    4. Data indicate that the major binding site for binding of sorting nexin 17 (SNX17) is confined to the NPXF2 motif in cytoplasmic adaptor protein Krev interaction trapped 1 (KRIT1). PMID: 25059659
    5. Sorting nexin 17 regulates ApoER2 recycling and reelin signaling. PMID: 24705369
    6. The authors demonstrate that SNX17 is essential for infection with all papillomavirus types analyzed, indicating an evolutionarily highly conserved virus entry mechanism. PMID: 23115288
    7. depletion of SNX17 in HeLa cells resulted in lysosomal degradation of multiple members of the integrin family of extracellular matrix recep-tors. PMID: 22492727
    8. expression level of SNX17 may regulate the lysosomal degradation, at least for P-selectin, by suppressing its entry into the inner vesicles of the multi-vesicular bodies (MVBs) PMID: 15769472
    9. Snx 17 binds to a motif in the low-density lipoprotein (LDL) receptor-related protein (LRP) tail distinct from the endocytosis signals and promotes LRP sorting to the recycling pathway in the early endosomes. PMID: 16052210
    10. SNX17 has a role in the indicated KRIT1 function in cell adhesion processes by integrin signaling PMID: 16712798
    11. SNX17 regulates amyloid precursor protein trafficking and processing in the early endosomes PMID: 18276590

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  • 亞細(xì)胞定位：
    Cytoplasm. Early endosome. Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side.
  • 蛋白家族：
    Sorting nexin family
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 14979

    OMIM: 605963

    KEGG: hsa:9784

    STRING: 9606.ENSP00000233575

    UniGene: Hs.278569



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