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  4. SNX10 Antibody, Biotin conjugated

SNX10 Antibody, Biotin conjugated

  • 中文名稱：
    SNX10兔多克隆抗體, Biotin偶聯(lián)
  • 貨號：
    CSB-PA896538LD01HU
  • 規(guī)格：
    ￥880
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) SNX10 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    SNX10
  • 別名：
    2410004M09Rik antibody; MGC109202 antibody; MGC33054 antibody; OPTB8 antibody; SNX10 antibody; SNX10_HUMAN antibody; Sorting nexin 10 antibody; Sorting nexin-10 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human Sorting nexin-10 protein (124-201AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Biotin
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    Probable phosphoinositide-binding protein involved in protein sorting and membrane trafficking in endosomes. Plays a role in cilium biogenesis through regulation of the transport and the localization of proteins to the cilium. Required for the localization to the cilium of V-ATPase subunit ATP6V1D and ATP6V0D1, and RAB8A. Involved in osteoclast differentiation and therefore bone resorption.
  • 基因功能參考文獻：
    1. supplementation with calcium gluconate rescued mice from the rachitic phenotype and extended life span in global Snx10-deficient mice, suggesting that this may be a life-saving component of the clinical approach to Snx10-dependent human osteopetrosis PMID: 25811986
    2. Data suggest Tyr32 and Arg51 in SNX10 are important for protein stability and play critical roles in vacuolation in osteoclasts; mutation Arg16Leu (seen in autosomal recessive osteopetrosis patients) affects protein-protein interactions of SNX10. PMID: 25212774
    3. results confirm the involvement of the SNX10 gene in human ARO and identify a new subset with a relatively favorable prognosis as compared to TCIRG1-dependent cases PMID: 23280965
    4. Structure of sorting nexin 11 (SNX11) reveals a novel extended phox homology (PX) domain critical for inhibition of SNX10-induced vacuolation. PMID: 23615901
    5. Since inhibition of vesicular trafficking is essential for osteoclast formation and activity and SNX10 is involved in vesicular trafficking, these studies may identify a new gene involved in the development of bone diseases including osteoporosis. PMID: 22174188
    6. Identification of SNX10 as a new osteopetrosis associated gene in consanguineous families of Palestinian origin. PMID: 22499339
    7. SNX10 regulates the ciliary trafficking of Rab8a, which is a critical regulator of ciliary membrane extension. PMID: 21844891
    8. SNX10 activity may be involved in the regulation of endosome homeostasis PMID: 17012226

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  • 相關(guān)疾病：
    Osteopetrosis, autosomal recessive 8 (OPTB8)
  • 亞細胞定位：
    Cytoplasm. Endosome membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=May also localize to nucleus and endoplasmic reticulum.
  • 蛋白家族：
    Sorting nexin family
  • 數(shù)據(jù)庫鏈接：

    HGNC: 14974

    OMIM: 614780

    KEGG: hsa:29887

    STRING: 9606.ENSP00000343709

    UniGene: Hs.741316



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