在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

SMYD2 Antibody

  • 中文名稱:
    SMYD2兔多克隆抗體
  • 貨號:
    CSB-PA153500
  • 規格:
    ¥1100
  • 圖片:
    • The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA153500(SMYD2 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using CSB-PA153500(SMYD2 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: ×200)
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
    SMYD2
  • 別名:
    Histone methyltransferase SMYD2 antibody; HSKM B antibody; HSKM-B antibody; HSKMB antibody; KMT3C antibody; Lysine N-methyltransferase 3C antibody; MGC119305 antibody; N lysine methyltransferase SMYD2 antibody; N-lysine methyltransferase SMYD2 antibody; SET and MYND domain containing 2 antibody; SET and MYND domain containing protein 2 antibody; SET and MYND domain-containing protein 2 antibody; Smyd2 antibody; SMYD2_HUMAN antibody; Zinc finger MYND domain containing 14 antibody; ZMYND14 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Synthetic peptide of Human SMYD2
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen affinity purification
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    IHC 1:25-1:100
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Protein-lysine N-methyltransferase that methylates both histones and non-histone proteins, including p53/TP53 and RB1. Specifically trimethylates histone H3 'Lys-4' (H3K4me3) in vivo. The activity requires interaction with HSP90alpha. Shows even higher methyltransferase activity on p53/TP53. Monomethylates 'Lys-370' of p53/TP53, leading to decreased DNA-binding activity and subsequent transcriptional regulation activity of p53/TP53. Monomethylates RB1 at 'Lys-860'.
  • 基因功能參考文獻:
    1. We show that tool compounds as well as CRISPR/Cas9 fail to reproduce many of the cell proliferation findings associated with SMYD2 and SMYD3 inhibition previously obtained with RNAi based approaches and with early stage chemical probes. PMID: 29856759
    2. Lysine methylation represses p53 activity in teratocarcinoma cancer cells via up-regulation of SMYD2 and PR-Set7 and perpetuation of cancer cells proliferation. PMID: 27535933
    3. SMYD2-H4K20me1-L3MBTL1 axis contributes to HIV-1 latency and can be targeted with small-molecule SMYD2 inhibitors. PMID: 28494238
    4. identifie novel cellular substrates of the lysine methyltransferase SMYD2. Of the 14 novel putative SMYD2 substrates identified, six were confirmed in cells by immunoprecipitation: MAPT, CCAR2, EEF2, NCOA3, STUB1, and UTP14A. Treatment with the selective SMYD2 inhibitor BAY-598 abrogated the methylation signal, indicating that methylation of these novel substrates was dependent on the catalytic activity of SMYD2 PMID: 27163177
    5. The SMYD2 may promote BMP signaling by directly methylating BMPR2, which, in turn, stimulates BMPR2 kinase activity and activation of the BMP pathway. PMID: 28588028
    6. Knockdown of SMYD2 as well as treatment with a SMYD2 inhibitor in two NSCLC cell lines with an EML4-ALK gene significantly attenuated the phosphorylation levels of the EML4-ALK protein. PMID: 28370702
    7. SMYD2 knockdown confers relative resistance to human AML cells against multiple classes of DNA damaging agents. PMID: 28187429
    8. Substrate crevices of Smyd2 and Smyd3 show distinct features in terms of spatial, hydration, and electrostatic properties that emphasize their characteristic modes of substrates interaction and entry pathways for inhibitor binding. PMID: 27959541
    9. High expression of SMYD2 is associated with chronic lymphocytic leukemia. PMID: 26790435
    10. Study reveals a collection of 10 enriched sequence motifs in Kme1 sites that were identified upon SMYD2 overexpression which were also downregulated in response to SMYD2 knockdown. These findings suggest that these motifs reflect the substrate specificity of SMYD2 in esophageal squamous cell carcinoma cell line. PMID: 26750096
    11. Results show that high expression levels of SMYD2, SETD3, and NO66 in renal cell tumors. Their low expression levels were significantly associated with shorter disease-specific and disease-free survival. PMID: 26488939
    12. Suggest that SMYD2 plays a role in tumor progression and might be a useful prognosticator in HPV-unrelated, nonmultiple head and neck squamous cell carcinomas. PMID: 26826421
    13. SMYD2-mediated methylation negatively regulates PTEN tumor suppressor activity and results in activation of the phosphatidylinositol 3-kinase-AKT pathway. PMID: 25925379
    14. Comprehensive motif-based searches and mutational analysis further established four additional substrates of SMYD2. PMID: 25533488
    15. in addition to esophageal squamous cell carcinoma, SMYD2 is also amplified and/or overexpressed in breast and liver primary tumors PMID: 25825497
    16. a novel mechanism of PARP1 in human cancer through its methylation by SMYD2 PMID: 24726141
    17. SMYD2 has a crucial role in tumor cell proliferation by its overexpression and highlight its usefulness as a prognostic factor and potential therapeutic target in gastric cancer. PMID: 25321194
    18. Data indicate that irect estrogen receptor alpha (ERalpha) methylation by histone methyltransferase SMYD2 regulates estrogen signaling. PMID: 24594358
    19. A novel mechanism for human carcinogenesis via methylation of HSP90AB1 by SMYD2. PMID: 24880080
    20. SMYD2 expression is altered in acute lymphoblastic leukemia bone marrow samples and its high expression was correlated with a bad prognosis. Moreover, SMYD2 expression level significantly decreases in patients that respond to chemotherapy treatment. PMID: 24631370
    21. Findings suggest that SMYD2 (SET and MYND domain containing protein 2), a histone lysine methyltransferase, in embryonic stem (ES) cell differentiation. PMID: 23873367
    22. Data suggest that SMYD2-mediated estrogen receptor alpha (ERalpha) protein methylation and p300/cAMP response element-binding protein-binding protein-dependent ERalpha acetylation play an important role in the estrogen-induced gene expression profiles. PMID: 24101509
    23. -dependent RB1 methylation at lysine 810 promotes cell cycle progression of cancer cells. Further study may explore SMYD2-dependent RB1 methylation as a potential therapeutic target in human cancer. PMID: 22787429
    24. Data report the crystal structure of the full-length human Smyd2 in complex with S-adenosyl-L-homocysteine (AdoHcy). PMID: 21724641
    25. Data highlights the ability of SMYD proteins to form unique protein complexes that may underlie their various biological functions and the SMYD2-mediated methylation of the key molecular chaperone HSP90. PMID: 22028380
    26. SMYD2 has a role in specifically recognizing and regulating functions of p53 tumor suppressor through Lys-370 monomethylation PMID: 21880715
    27. Structural basis of substrate methylation and inhibition of SMYD2 PMID: 21782458
    28. Substrate specificity and product analysis studies established SMYD2 as a monomethyltransferase that prefers nonmethylated p53 peptide substrate. PMID: 21678921
    29. SMYD2 gene expression is decreased in both classic and follicular variants of papillary thyroid carcinoma. PMID: 21509594
    30. RB monomethylation at lysine 860 by SMYD2 provides a direct binding site for L3MBTL1. PMID: 20870719
    31. The combination of the SMYD2 interactome with the gene expression data suggests that some of the genes regulated by SMYD2 are closely associated with SMYD2-interacting proteins. PMID: 18065756
    32. SMYD2 plays an important role in tumor cell proliferation through its activation/overexpression and highlight its usefulness as a prognosticator and potential therapeutic target in ESCC. PMID: 19423649

    顯示更多

    收起更多

  • 亞細胞定位:
    Cytoplasm, cytosol. Nucleus.
  • 蛋白家族:
    Class V-like SAM-binding methyltransferase superfamily
  • 數據庫鏈接:

    HGNC: 20982

    OMIM: 610663

    KEGG: hsa:56950

    STRING: 9606.ENSP00000355924

    UniGene: Hs.66170



主站蜘蛛池模板: 另类亚洲综合区图片区小说| 黑人巨大精品欧美一区二区| 性做久久久久久久久| 激情五月综合色婷婷一区二区| 中国精品少妇hd| 久久婷婷五月综合97色直播| 国产精品无打码在线播放| 久久久久人妻精品区一三寸| 欧美精品人人做人人爱视频| 影音先锋女人av鲁色资源网久久| 国产精品福利自产拍在线观看| 国内久久婷婷五月综合色| 国产一区二区不卡在线看| 亚洲欧美不卡视频在线播放| 久久久日韩精品一区二区| 美女内射视频www网站午夜| av在线 高清不卡区| 无码帝国www无码专区色综合| 激情综合一区二区三区| 国产后入又长又硬| 天天综合天天做天天综合| 国产精品白浆在线观看免费| 一本大道东京热无码视频| 国产成人涩涩涩视频在线观看| 国产无套乱子伦精彩是白视频| 永久免费男同av无码入口| 无码人妻日韩一区日韩二区| 久久精品国产99久久久| 亚洲成a人片在线观看www| 狠狠色噜噜狼狼狼色综合久| 一区二区视频日韩免费| 三级男人添奶爽爽爽视频| 性色av免费观看| 久久午夜无码鲁丝片秋霞| 亚欧成人中文字幕一区| 日韩精品成人一区二区三区| 国产激情视频一区二区三区| 精品国产乱码久久久久久乱码| 中文字幕亚洲码在线观看| 国产色视频一区二区三区| 美女被张开双腿日出白浆|