在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

SMYD2 Antibody

  • 中文名稱:
    SMYD2兔多克隆抗體
  • 貨號:
    CSB-PA004122
  • 規格:
    ¥1090
  • 圖片:
    • Western Blot analysis of HT29 cells using SMYD2 Polyclonal Antibody
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
    SMYD2
  • 別名:
    Histone methyltransferase SMYD2 antibody; HSKM B antibody; HSKM-B antibody; HSKMB antibody; KMT3C antibody; Lysine N-methyltransferase 3C antibody; MGC119305 antibody; N lysine methyltransferase SMYD2 antibody; N-lysine methyltransferase SMYD2 antibody; SET and MYND domain containing 2 antibody; SET and MYND domain containing protein 2 antibody; SET and MYND domain-containing protein 2 antibody; Smyd2 antibody; SMYD2_HUMAN antibody; Zinc finger MYND domain containing 14 antibody; ZMYND14 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Synthesized peptide derived from the Internal region of Human SMYD2.
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    WB, ELISA
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:2000
    ELISA 1:10000
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Protein-lysine N-methyltransferase that methylates both histones and non-histone proteins, including p53/TP53 and RB1. Specifically trimethylates histone H3 'Lys-4' (H3K4me3) in vivo. The activity requires interaction with HSP90alpha. Shows even higher methyltransferase activity on p53/TP53. Monomethylates 'Lys-370' of p53/TP53, leading to decreased DNA-binding activity and subsequent transcriptional regulation activity of p53/TP53. Monomethylates RB1 at 'Lys-860'.
  • 基因功能參考文獻:
    1. We show that tool compounds as well as CRISPR/Cas9 fail to reproduce many of the cell proliferation findings associated with SMYD2 and SMYD3 inhibition previously obtained with RNAi based approaches and with early stage chemical probes. PMID: 29856759
    2. Lysine methylation represses p53 activity in teratocarcinoma cancer cells via up-regulation of SMYD2 and PR-Set7 and perpetuation of cancer cells proliferation. PMID: 27535933
    3. SMYD2-H4K20me1-L3MBTL1 axis contributes to HIV-1 latency and can be targeted with small-molecule SMYD2 inhibitors. PMID: 28494238
    4. identifie novel cellular substrates of the lysine methyltransferase SMYD2. Of the 14 novel putative SMYD2 substrates identified, six were confirmed in cells by immunoprecipitation: MAPT, CCAR2, EEF2, NCOA3, STUB1, and UTP14A. Treatment with the selective SMYD2 inhibitor BAY-598 abrogated the methylation signal, indicating that methylation of these novel substrates was dependent on the catalytic activity of SMYD2 PMID: 27163177
    5. The SMYD2 may promote BMP signaling by directly methylating BMPR2, which, in turn, stimulates BMPR2 kinase activity and activation of the BMP pathway. PMID: 28588028
    6. Knockdown of SMYD2 as well as treatment with a SMYD2 inhibitor in two NSCLC cell lines with an EML4-ALK gene significantly attenuated the phosphorylation levels of the EML4-ALK protein. PMID: 28370702
    7. SMYD2 knockdown confers relative resistance to human AML cells against multiple classes of DNA damaging agents. PMID: 28187429
    8. Substrate crevices of Smyd2 and Smyd3 show distinct features in terms of spatial, hydration, and electrostatic properties that emphasize their characteristic modes of substrates interaction and entry pathways for inhibitor binding. PMID: 27959541
    9. High expression of SMYD2 is associated with chronic lymphocytic leukemia. PMID: 26790435
    10. Study reveals a collection of 10 enriched sequence motifs in Kme1 sites that were identified upon SMYD2 overexpression which were also downregulated in response to SMYD2 knockdown. These findings suggest that these motifs reflect the substrate specificity of SMYD2 in esophageal squamous cell carcinoma cell line. PMID: 26750096
    11. Results show that high expression levels of SMYD2, SETD3, and NO66 in renal cell tumors. Their low expression levels were significantly associated with shorter disease-specific and disease-free survival. PMID: 26488939
    12. Suggest that SMYD2 plays a role in tumor progression and might be a useful prognosticator in HPV-unrelated, nonmultiple head and neck squamous cell carcinomas. PMID: 26826421
    13. SMYD2-mediated methylation negatively regulates PTEN tumor suppressor activity and results in activation of the phosphatidylinositol 3-kinase-AKT pathway. PMID: 25925379
    14. Comprehensive motif-based searches and mutational analysis further established four additional substrates of SMYD2. PMID: 25533488
    15. in addition to esophageal squamous cell carcinoma, SMYD2 is also amplified and/or overexpressed in breast and liver primary tumors PMID: 25825497
    16. a novel mechanism of PARP1 in human cancer through its methylation by SMYD2 PMID: 24726141
    17. SMYD2 has a crucial role in tumor cell proliferation by its overexpression and highlight its usefulness as a prognostic factor and potential therapeutic target in gastric cancer. PMID: 25321194
    18. Data indicate that irect estrogen receptor alpha (ERalpha) methylation by histone methyltransferase SMYD2 regulates estrogen signaling. PMID: 24594358
    19. A novel mechanism for human carcinogenesis via methylation of HSP90AB1 by SMYD2. PMID: 24880080
    20. SMYD2 expression is altered in acute lymphoblastic leukemia bone marrow samples and its high expression was correlated with a bad prognosis. Moreover, SMYD2 expression level significantly decreases in patients that respond to chemotherapy treatment. PMID: 24631370
    21. Findings suggest that SMYD2 (SET and MYND domain containing protein 2), a histone lysine methyltransferase, in embryonic stem (ES) cell differentiation. PMID: 23873367
    22. Data suggest that SMYD2-mediated estrogen receptor alpha (ERalpha) protein methylation and p300/cAMP response element-binding protein-binding protein-dependent ERalpha acetylation play an important role in the estrogen-induced gene expression profiles. PMID: 24101509
    23. -dependent RB1 methylation at lysine 810 promotes cell cycle progression of cancer cells. Further study may explore SMYD2-dependent RB1 methylation as a potential therapeutic target in human cancer. PMID: 22787429
    24. Data report the crystal structure of the full-length human Smyd2 in complex with S-adenosyl-L-homocysteine (AdoHcy). PMID: 21724641
    25. Data highlights the ability of SMYD proteins to form unique protein complexes that may underlie their various biological functions and the SMYD2-mediated methylation of the key molecular chaperone HSP90. PMID: 22028380
    26. SMYD2 has a role in specifically recognizing and regulating functions of p53 tumor suppressor through Lys-370 monomethylation PMID: 21880715
    27. Structural basis of substrate methylation and inhibition of SMYD2 PMID: 21782458
    28. Substrate specificity and product analysis studies established SMYD2 as a monomethyltransferase that prefers nonmethylated p53 peptide substrate. PMID: 21678921
    29. SMYD2 gene expression is decreased in both classic and follicular variants of papillary thyroid carcinoma. PMID: 21509594
    30. RB monomethylation at lysine 860 by SMYD2 provides a direct binding site for L3MBTL1. PMID: 20870719
    31. The combination of the SMYD2 interactome with the gene expression data suggests that some of the genes regulated by SMYD2 are closely associated with SMYD2-interacting proteins. PMID: 18065756
    32. SMYD2 plays an important role in tumor cell proliferation through its activation/overexpression and highlight its usefulness as a prognosticator and potential therapeutic target in ESCC. PMID: 19423649

    顯示更多

    收起更多

  • 亞細胞定位:
    Cytoplasm, cytosol. Nucleus.
  • 蛋白家族:
    Class V-like SAM-binding methyltransferase superfamily
  • 數據庫鏈接:

    HGNC: 20982

    OMIM: 610663

    KEGG: hsa:56950

    STRING: 9606.ENSP00000355924

    UniGene: Hs.66170



主站蜘蛛池模板: 国产精品理论片| 亚洲国产精品一区二区动图| 婷婷五月俺也去人妻| 俄罗斯少妇性xxxx另类| 欧美在线观看免费专区| 亚洲中文字幕久久精品无码喷水| 久久久久国产精品无码免费看| 国产亚洲日韩欧美另类第八页| 国语做受对白xxxxx在线| 国产美女午夜福利视频| 久久av高潮av无码av| 天天天天躁天天爱天天碰2018 | 亚洲午夜无码av毛片久久| 国产亚洲高清国产拍精品| 亚洲大码熟女在线观看| 久久久久久无码av成人影院| 天天鲁一鲁摸一摸爽一爽| 国产最新进精品视频| 国产精品久久久久久麻豆一区| 久久中文字幕乱码久久午夜| 亚洲日韩色欲色欲com| 久久人妻av一区二区软件| 国产乱子经典视频在线观看| 伊人久久大香线蕉综合5g| 在线观看免费视频网站a站| 男人扒开女人腿桶到爽免费 | 亚洲国产av一区二区三区| 久久国产精品一国产精品| 国产熟妇午夜精品aaa| 午夜亚洲国产理论片中文| 亚洲人成伊人成综合网久久久| 男女猛烈无遮挡免费视频| 国产gv在线观看受被做哭| 国厂精品114福利电影免费| 国产av天堂亚洲国产av麻豆| 四虎影视在线影院在线观看免费视频| 麻豆人妻少妇精品无码专区| 人妻久久久精品99系列2021| 午夜伦费影视在线观看| 欧美乱妇高清无乱码在线观看| 午夜福利片手机在线播放|