在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. SMC6 Antibody

SMC6 Antibody

  • 中文名稱：
    SMC6兔多克隆抗體
  • 貨號：
    CSB-PA836300LA01HU
  • 規格：
    ￥440
  • 圖片：
    • IHC image of CSB-PA836300LA01HU diluted at 1:400 and staining in paraffin-embedded human testis tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) SMC6 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    SMC6
  • 別名：
    FLJ22116 antibody; FLJ35534 antibody; hSMC6 antibody; SMC 6 antibody; SMC protein 6 antibody; SMC-6 antibody; SMC6 antibody; SMC6 protein antibody; SMC6 structural maintenance of chromosomes 6 like 1 antibody; SMC6_HUMAN antibody; Smc6l1 antibody; Structural maintenance of chromosomes 6 antibody; Structural maintenance of chromosomes 6 like 1 antibody; Structural maintenance of chromosomes protein 6 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Structural maintenance of chromosomes protein 6 protein (309-450AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated

    本頁面中的產品，SMC6 Antibody (CSB-PA836300LA01HU)，的標記方式是Non-conjugated。對于SMC6 Antibody，我們還提供其他標記。見下表：

    可提供標記
    標記方式 貨號 產品名稱 應用
    HRP CSB-PA836300LB01HU SMC6 Antibody, HRP conjugated ELISA
    FITC CSB-PA836300LC01HU SMC6 Antibody, FITC conjugated
    Biotin CSB-PA836300LD01HU SMC6 Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:200-1:500
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Core component of the SMC5-SMC6 complex, a complex involved in DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). Required for recruitment of telomeres to PML nuclear bodies. SMC5-SMC6 complex may prevent transcription of episomal DNA, such as circular viral DNA genome.
  • 基因功能參考文獻：
    1. Study shows that the SMC5/6-hinge complex binds preferentially to ssDNA and that this interaction is affected by both 'latch' and 'hub' mutations, suggesting a key role for these unique features in controlling DNA association by the SMC5/6 complex. PMID: 28134253
    2. SMC5/6 knockdown rescued HBx-deficient hepatitis b virus replication in human hepatocytes. PMID: 27626656
    3. High SMC6 protein is associated with hepatitis B. PMID: 28095508
    4. Brazilian Amerindian ancestry compared to Asian, European, and African Genomes.SNPs within or proximal to CIITA (rs6498115), SMC6 (rs1834619), and KLHL29 (rs2288697) were most differentiated in the Amerindian-specific branch. SNPs in ADAMTS9 (rs7631391), DOCK2 (rs77594147), SLC28A1 (rs28649017), ARHGAP5 (rs7151991), and CIITA (rs45601437) in the Asian comparison. PMID: 28100790
    5. The SMC5/6 complex physically interacts with the DNA topoisomerase II alpha (TOP2A). PMID: 27792189
    6. results uncover a novel role for the Smc5/6 complex as a restriction factor selectively blocking extrachromosomal DNA transcription; by destroying this complex, HBx relieves the inhibition to allow productive hepatitis B virus gene expression PMID: 26983541
    7. Structural maintenance of chromosomes (SMC) complexes, which in eukaryotic cells include cohesin, condensin and the Smc5/6 complex, are central regulators of chromosome dynamics PMID: 25145851
    8. Depletion of Smc5 and Smc6 resulted in aberrant mitotic chromosome phenotypes that were accompanied by the abnormal distribution of topoisomerase IIalpha (topo IIalpha) and condensins and by chromosome segregation errors PMID: 24258023
    9. Studies indicate that Nse1 may function as a ubiquitin ligase, and is targeted to chromatin through its interaction with the Smc5/6 complex. PMID: 21550342
    10. the human SMC5/6 complex and the SUMO ligase activity of hMMS21 are required for the prevention of DNA damage-induced apoptosis by facilitating DNA repair in human cells PMID: 16055714
    11. SMC5/6 complex is recruited to nuclease-induced double-strand breaks (DSBs) and is required for the recruitment of cohesin to DSBs. PMID: 16810316
    12. SMC5/6 complex facilitates telomere homologous recombination and elongation in alternative lengthening of telomeres cells through SUMOylation of telomere-binding proteins. PMID: 17589526
    13. Nse1 RING-like motif is a protein-protein interaction domain required for Smc5-Smc6 holocomplex integrity and recruitment to, or retention at, DNA lesions PMID: 18667531

    顯示更多

    收起更多

  • 亞細胞定位：
    Nucleus. Nucleus speckle. Chromosome. Nucleus, PML body. Chromosome, telomere.
  • 蛋白家族：
    SMC family, SMC6 subfamily
  • 組織特異性：
    Widely expressed. Strongly expressed in testis.
  • 數據庫鏈接：

    HGNC: 20466

    OMIM: 609387

    KEGG: hsa:79677

    STRING: 9606.ENSP00000323439

    UniGene: Hs.526728



主站蜘蛛池模板： 色噜噜狠狠成人中文综合| 日本无遮挡真人祼交视频| 免费人成网站在线观看欧美| 日韩av中文无码影院| 国产亚洲精品久久无码98| 玩弄japan白嫩少妇hd小说| 无码色偷偷亚洲国内自拍| 国产成人精品三级在线影院| 国产av一二三无码影片| 亚洲精品高清无码视频| 国产手机在线国内精品| 日本午夜看x费免| 中文在线天堂а√在线| 国产精品一品二区三区的使用体验| 国产三区在线成人av| 欧美精品黑人粗大破除| 中文无码人妻有码人妻中文字幕| 99re6在线视频精品免费下载 | 久久这里精品国产99丫e6| 亚洲日韩精品a∨片无码加勒比 | 久久久久久久无码高潮| 另类国产精品一区二区| 欧美成人午夜免费影院手机在线看| 无码国内精品人妻少妇蜜桃视频| 亚洲va久久久噜噜噜久久天堂 | 午夜在线a亚洲v天堂网2018| 日日大香人伊一本线久| 成人美女黄网站色大免费的| 女人张开腿让男桶喷水高潮| 欧美成人精品一区二区综合a片| 波多野结衣一区二区三区av免费| 五月av综合av国产av| 亚洲精品久久午夜无码一区二区| 92国产精品午夜福利无毒不卡| 麻豆一区二区99久久久久| 国产一区二区三区影院| 久久久久久久精品成人执小说一白| 99国产精品久久久久久久久久久| 国产精品免费一区二区三区四区| 无码人妻精品丰满熟妇区| 国产精品福利一区二区久久|