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  4. SMC6 Antibody

SMC6 Antibody

  • 中文名稱：
    SMC6兔多克隆抗體
  • 貨號：
    CSB-PA571155
  • 規格：
    ￥1100
  • 圖片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA571155(SMC6 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using CSB-PA571155(SMC6 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: ×200)
    • Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane 1-2: 293T cells, hela cells, Primary antibody: CSB-PA571155(SMC6 Antibody) at dilution 1/400, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
    SMC6
  • 別名：
    FLJ22116 antibody; FLJ35534 antibody; hSMC6 antibody; SMC 6 antibody; SMC protein 6 antibody; SMC-6 antibody; SMC6 antibody; SMC6 protein antibody; SMC6 structural maintenance of chromosomes 6 like 1 antibody; SMC6_HUMAN antibody; Smc6l1 antibody; Structural maintenance of chromosomes 6 antibody; Structural maintenance of chromosomes 6 like 1 antibody; Structural maintenance of chromosomes protein 6 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Synthetic peptide of Human SMC6
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen affinity purification
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA,WB,IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    ELISA 1:1000-1:2000
    WB 1:200-1:1000
    IHC 1:25-1:100
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Core component of the SMC5-SMC6 complex, a complex involved in DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). Required for recruitment of telomeres to PML nuclear bodies. SMC5-SMC6 complex may prevent transcription of episomal DNA, such as circular viral DNA genome.
  • 基因功能參考文獻：
    1. Study shows that the SMC5/6-hinge complex binds preferentially to ssDNA and that this interaction is affected by both 'latch' and 'hub' mutations, suggesting a key role for these unique features in controlling DNA association by the SMC5/6 complex. PMID: 28134253
    2. SMC5/6 knockdown rescued HBx-deficient hepatitis b virus replication in human hepatocytes. PMID: 27626656
    3. High SMC6 protein is associated with hepatitis B. PMID: 28095508
    4. Brazilian Amerindian ancestry compared to Asian, European, and African Genomes.SNPs within or proximal to CIITA (rs6498115), SMC6 (rs1834619), and KLHL29 (rs2288697) were most differentiated in the Amerindian-specific branch. SNPs in ADAMTS9 (rs7631391), DOCK2 (rs77594147), SLC28A1 (rs28649017), ARHGAP5 (rs7151991), and CIITA (rs45601437) in the Asian comparison. PMID: 28100790
    5. The SMC5/6 complex physically interacts with the DNA topoisomerase II alpha (TOP2A). PMID: 27792189
    6. results uncover a novel role for the Smc5/6 complex as a restriction factor selectively blocking extrachromosomal DNA transcription; by destroying this complex, HBx relieves the inhibition to allow productive hepatitis B virus gene expression PMID: 26983541
    7. Structural maintenance of chromosomes (SMC) complexes, which in eukaryotic cells include cohesin, condensin and the Smc5/6 complex, are central regulators of chromosome dynamics PMID: 25145851
    8. Depletion of Smc5 and Smc6 resulted in aberrant mitotic chromosome phenotypes that were accompanied by the abnormal distribution of topoisomerase IIalpha (topo IIalpha) and condensins and by chromosome segregation errors PMID: 24258023
    9. Studies indicate that Nse1 may function as a ubiquitin ligase, and is targeted to chromatin through its interaction with the Smc5/6 complex. PMID: 21550342
    10. the human SMC5/6 complex and the SUMO ligase activity of hMMS21 are required for the prevention of DNA damage-induced apoptosis by facilitating DNA repair in human cells PMID: 16055714
    11. SMC5/6 complex is recruited to nuclease-induced double-strand breaks (DSBs) and is required for the recruitment of cohesin to DSBs. PMID: 16810316
    12. SMC5/6 complex facilitates telomere homologous recombination and elongation in alternative lengthening of telomeres cells through SUMOylation of telomere-binding proteins. PMID: 17589526
    13. Nse1 RING-like motif is a protein-protein interaction domain required for Smc5-Smc6 holocomplex integrity and recruitment to, or retention at, DNA lesions PMID: 18667531

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  • 亞細胞定位：
    Nucleus. Nucleus speckle. Chromosome. Nucleus, PML body. Chromosome, telomere.
  • 蛋白家族：
    SMC family, SMC6 subfamily
  • 組織特異性：
    Widely expressed. Strongly expressed in testis.
  • 數據庫鏈接：

    HGNC: 20466

    OMIM: 609387

    KEGG: hsa:79677

    STRING: 9606.ENSP00000323439

    UniGene: Hs.526728



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