在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. SLC8A3 Antibody

SLC8A3 Antibody

  • 中文名稱：
    SLC8A3兔多克隆抗體
  • 貨號：
    CSB-PA966001
  • 規格：
    ￥1100
  • 圖片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human tonsil tissue using CSB-PA966001(SLC8A3 Antibody) at dilution 1/35, on the right is treated with synthetic peptide. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using CSB-PA966001(SLC8A3 Antibody) at dilution 1/35, on the right is treated with synthetic peptide. (Original magnification: ×200)
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
  • 別名：
    SLC8A3 antibody; NCX3 antibody; Sodium/calcium exchanger 3 antibody; Na(+)/Ca(2+)-exchange protein 3 antibody; Solute carrier family 8 member 3 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human,Rat
  • 免疫原：
    Synthetic peptide of Human SLC8A3
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen affinity purification
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA,IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    ELISA 1:1000-1:2000
    IHC 1:25-1:100
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Mediates the electrogenic exchange of Ca(2+) against Na(+) ions across the cell membrane, and thereby contributes to the regulation of cytoplasmic Ca(2+) levels and Ca(2+)-dependent cellular processes. Contributes to cellular Ca(2+) homeostasis in excitable cells, both in muscle and in brain. In a first phase, voltage-gated channels mediate the rapid increase of cytoplasmic Ca(2+) levels due to release of Ca(2+) stores from the endoplasmic reticulum. SLC8A3 mediates the export of Ca(2+) from the cell during the next phase, so that cytoplasmic Ca(2+) levels rapidly return to baseline. Contributes to Ca(2+) transport during excitation-contraction coupling in muscle. In neurons, contributes to the rapid decrease of cytoplasmic Ca(2+) levels back to baseline after neuronal activation, and thereby contributes to modulate synaptic plasticity, learning and memory. Required for normal oligodendrocyte differentiation and for normal myelination. Mediates Ca(2+) efflux from mitochondria and contributes to mitochondrial Ca(2+) ion homeostasis.
  • 基因功能參考文獻：
    1. These results...suggest that cells can use a dynamic Ca(2+) signaling toolkit in which the NCX3 sub-cellular localization changes in synchrony with the cell cycle PMID: 29526322
    2. stimulation of NCX3 by PKA occurred through residue S524. This effect may well participate in the fight-or-flight response in skeletal muscle and the long-term potentiation in hippocampus. PMID: 28233567
    3. In the discovery phase, 60 loci not previously associated with rheumatoid arthritis risk showed evidence for association and were tested for replication in the validation cohort. A total of 12 loci were replicated at the nominal level. When combining the discovery and validation cohorts, an intronic SNP in SLC8A3 was found to be associated with ACPA-positive rheumatoid arthritis at a genome-wide level of significance. PMID: 26983453
    4. Ayloid beta mediates calpain cleavage of NCX3 in Alzheimer's disease brain. PMID: 23919677
    5. calcium signaling mediated by NCX3 has a crucial role in oligodendrocyte maturation and myelin formation. PMID: 21959935
    6. The gene promoter of the human isoform of this protein is controlled by cAMP and calcium. PMID: 12502570
    7. This review examines the regulatory features and expression pattern of the SLC8A3 gene which suggest that NCX3 activity could be crucial in neuronal functions such as memory formation and sensory processing. PMID: 15247490
    8. Studies show that both alternatively spliced variants can be translated into protein. PMID: 15777725
    9. The downregulation of the regulator of Ca2+ homeostasis NCX3 by Ca2+-regulated DREAM is a striking example of the autoregulatory property of the Ca2+ signal in neurons. PMID: 16306395

    顯示更多

    收起更多

  • 亞細胞定位：
    Cell membrane; Multi-pass membrane protein. Perikaryon. Cell projection, dendrite. Cell projection, dendritic spine. Cell membrane, sarcolemma. Cytoplasm, sarcoplasm. Cell junction. Mitochondrion outer membrane; Multi-pass membrane protein. Cytoplasm, perinuclear region. Endoplasmic reticulum membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family, SLC8 subfamily
  • 組織特異性：
    Isoform 2 is expressed in brain and skeletal muscle. Isoform 3 is expressed in excitable cells of brain, retina and skeletal muscle. Isoform 4 is expressed in skeletal muscle.
  • 數據庫鏈接：

    HGNC: 11070

    OMIM: 607991

    KEGG: hsa:6547

    STRING: 9606.ENSP00000370669

    UniGene: Hs.337696



主站蜘蛛池模板： 亚洲精品久久久久久久观小说| 国产精久久一区二区三区| 国产麻豆精品一区| 国产一区二区| 国产精品亚洲一区二区三区| 九色综合九色综合色鬼| 中文资源在线天堂库8| 无码少妇一区二区三区视频| 男人用嘴添女人下身免费视频| 精品一区二区三区在线成人 | 无码任你躁久久久久久久| 国产女人精品视频国产灰线| 色多多成视频人在线观看| 亚洲一区在线日韩在线尤物| 亚洲欧美日韩综合av| 婷婷色香五月综合激激情| 青青草国产成人99久久| 国产精品久久久国产盗摄| 国内精品久久久久影院老司机| 中文字幕久久久久人妻| 亚洲高清毛片一区二区| 爽爽影院免费观看视频| 国产欧美精品一区二区三区-老狼 日本亲近相奷中文字幕 | 欧美日韩亚洲国产精品| 尤物视频在线观看| 无码国产精品免费看| 狠狠色老熟妇老熟女| 国产拍揄自揄精品视频| 日韩a∨精品日韩在线观看| 色噜噜狠狠一区二区三区| 天天躁日日躁狠狠久久| 丰满无码人妻熟妇无码区| 小嫩妇好紧好爽18禁视频| 国产一区二区三区乱码| 国产精品爆乳在线播放第一人称| 青青国产揄拍视频| 亚洲精品久久国产精品| 国产精品久久久久久av| 亚洲精品久久久久久| 日韩高清成片免费视频| 国产熟睡乱子伦午夜视频麻豆|