在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. SLC8A3 Antibody

SLC8A3 Antibody

  • 中文名稱：
    SLC8A3兔多克隆抗體
  • 貨號：
    CSB-PA335714
  • 規格：
    ￥1100
  • 圖片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA335714(SLC8A3 Antibody) at dilution 1/50, on the right is treated with synthetic peptide. (Original magnification: ×200)
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
  • 別名：
    SLC8A3 antibody; NCX3 antibody; Sodium/calcium exchanger 3 antibody; Na(+)/Ca(2+)-exchange protein 3 antibody; Solute carrier family 8 member 3 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Synthetic peptide of Human SLC8A3
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen affinity purification
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA,IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    ELISA 1:2000-1:10000
    IHC 1:50-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Mediates the electrogenic exchange of Ca(2+) against Na(+) ions across the cell membrane, and thereby contributes to the regulation of cytoplasmic Ca(2+) levels and Ca(2+)-dependent cellular processes. Contributes to cellular Ca(2+) homeostasis in excitable cells, both in muscle and in brain. In a first phase, voltage-gated channels mediate the rapid increase of cytoplasmic Ca(2+) levels due to release of Ca(2+) stores from the endoplasmic reticulum. SLC8A3 mediates the export of Ca(2+) from the cell during the next phase, so that cytoplasmic Ca(2+) levels rapidly return to baseline. Contributes to Ca(2+) transport during excitation-contraction coupling in muscle. In neurons, contributes to the rapid decrease of cytoplasmic Ca(2+) levels back to baseline after neuronal activation, and thereby contributes to modulate synaptic plasticity, learning and memory. Required for normal oligodendrocyte differentiation and for normal myelination. Mediates Ca(2+) efflux from mitochondria and contributes to mitochondrial Ca(2+) ion homeostasis.
  • 基因功能參考文獻：
    1. These results...suggest that cells can use a dynamic Ca(2+) signaling toolkit in which the NCX3 sub-cellular localization changes in synchrony with the cell cycle PMID: 29526322
    2. stimulation of NCX3 by PKA occurred through residue S524. This effect may well participate in the fight-or-flight response in skeletal muscle and the long-term potentiation in hippocampus. PMID: 28233567
    3. In the discovery phase, 60 loci not previously associated with rheumatoid arthritis risk showed evidence for association and were tested for replication in the validation cohort. A total of 12 loci were replicated at the nominal level. When combining the discovery and validation cohorts, an intronic SNP in SLC8A3 was found to be associated with ACPA-positive rheumatoid arthritis at a genome-wide level of significance. PMID: 26983453
    4. Ayloid beta mediates calpain cleavage of NCX3 in Alzheimer's disease brain. PMID: 23919677
    5. calcium signaling mediated by NCX3 has a crucial role in oligodendrocyte maturation and myelin formation. PMID: 21959935
    6. The gene promoter of the human isoform of this protein is controlled by cAMP and calcium. PMID: 12502570
    7. This review examines the regulatory features and expression pattern of the SLC8A3 gene which suggest that NCX3 activity could be crucial in neuronal functions such as memory formation and sensory processing. PMID: 15247490
    8. Studies show that both alternatively spliced variants can be translated into protein. PMID: 15777725
    9. The downregulation of the regulator of Ca2+ homeostasis NCX3 by Ca2+-regulated DREAM is a striking example of the autoregulatory property of the Ca2+ signal in neurons. PMID: 16306395

    顯示更多

    收起更多

  • 亞細胞定位：
    Cell membrane; Multi-pass membrane protein. Perikaryon. Cell projection, dendrite. Cell projection, dendritic spine. Cell membrane, sarcolemma. Cytoplasm, sarcoplasm. Cell junction. Mitochondrion outer membrane; Multi-pass membrane protein. Cytoplasm, perinuclear region. Endoplasmic reticulum membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family, SLC8 subfamily
  • 組織特異性：
    Isoform 2 is expressed in brain and skeletal muscle. Isoform 3 is expressed in excitable cells of brain, retina and skeletal muscle. Isoform 4 is expressed in skeletal muscle.
  • 數據庫鏈接：

    HGNC: 11070

    OMIM: 607991

    KEGG: hsa:6547

    STRING: 9606.ENSP00000370669

    UniGene: Hs.337696



主站蜘蛛池模板： 国产精品亚洲а∨无码播放不卡| 午夜免费无码福利视频麻豆| 丰满多毛的陰户视频| 日本一本一区二区免费播放| 成人免费无码大片a毛片| 看成年女人午夜毛片免费| 免费香蕉成视频人网站| 青青草在在观免费福利线观看| 久久99热狠狠色精品一区| 国内精品久久久久伊人av| 99精品热这里只有精品| 综合色一色综合久久网| 日产精品卡二卡三卡四卡区满十八| 99国产精品久久久久久久成人热 | 亚洲成a人v欧美综合天堂| 一本加勒比hezyo无码资源网| 久久/这里只精品热在线获取| 成人免费毛片内射美女app| 亚洲午夜精品久久久久久浪潮 | 99在线精品视频观看免费| 亚洲第一aaaaa片| 成人区精品一区二区婷婷| 日本人又黄又爽又色的视频| 国产午夜福利不卡在线秋霞秋霞| 国产熟人av一二三区| 免费看国产曰批40分钟| 欧美成aⅴ人高清免费| 国产a v高清一区二区三区| 欧美影院成年免费版| 无码日本精品xxxxxxxxx| 国产欧洲精品自在自线官方| 日韩av片无码一区二区不卡电影 | 又黄又爽又色视频免费| 伊伊人成亚洲综合人网| 国产偷窥熟女精品视频| 日本精品少妇一区二区三区| 免费观看潮喷到高潮中文字幕| 国内精品久久久久电影院| 亚洲色大成网站www永久男同| 97国产精品人妻无码久久久| 久久婷婷五月综合色俺也想去 |