在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. SLC8A3 Antibody

SLC8A3 Antibody

  • 中文名稱：
    SLC8A3兔多克隆抗體
  • 貨號：
    CSB-PA335714
  • 規格：
    ￥1100
  • 圖片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA335714(SLC8A3 Antibody) at dilution 1/50, on the right is treated with synthetic peptide. (Original magnification: ×200)
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
  • 別名：
    SLC8A3 antibody; NCX3 antibody; Sodium/calcium exchanger 3 antibody; Na(+)/Ca(2+)-exchange protein 3 antibody; Solute carrier family 8 member 3 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Synthetic peptide of Human SLC8A3
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen affinity purification
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA,IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    ELISA 1:2000-1:10000
    IHC 1:50-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Mediates the electrogenic exchange of Ca(2+) against Na(+) ions across the cell membrane, and thereby contributes to the regulation of cytoplasmic Ca(2+) levels and Ca(2+)-dependent cellular processes. Contributes to cellular Ca(2+) homeostasis in excitable cells, both in muscle and in brain. In a first phase, voltage-gated channels mediate the rapid increase of cytoplasmic Ca(2+) levels due to release of Ca(2+) stores from the endoplasmic reticulum. SLC8A3 mediates the export of Ca(2+) from the cell during the next phase, so that cytoplasmic Ca(2+) levels rapidly return to baseline. Contributes to Ca(2+) transport during excitation-contraction coupling in muscle. In neurons, contributes to the rapid decrease of cytoplasmic Ca(2+) levels back to baseline after neuronal activation, and thereby contributes to modulate synaptic plasticity, learning and memory. Required for normal oligodendrocyte differentiation and for normal myelination. Mediates Ca(2+) efflux from mitochondria and contributes to mitochondrial Ca(2+) ion homeostasis.
  • 基因功能參考文獻：
    1. These results...suggest that cells can use a dynamic Ca(2+) signaling toolkit in which the NCX3 sub-cellular localization changes in synchrony with the cell cycle PMID: 29526322
    2. stimulation of NCX3 by PKA occurred through residue S524. This effect may well participate in the fight-or-flight response in skeletal muscle and the long-term potentiation in hippocampus. PMID: 28233567
    3. In the discovery phase, 60 loci not previously associated with rheumatoid arthritis risk showed evidence for association and were tested for replication in the validation cohort. A total of 12 loci were replicated at the nominal level. When combining the discovery and validation cohorts, an intronic SNP in SLC8A3 was found to be associated with ACPA-positive rheumatoid arthritis at a genome-wide level of significance. PMID: 26983453
    4. Ayloid beta mediates calpain cleavage of NCX3 in Alzheimer's disease brain. PMID: 23919677
    5. calcium signaling mediated by NCX3 has a crucial role in oligodendrocyte maturation and myelin formation. PMID: 21959935
    6. The gene promoter of the human isoform of this protein is controlled by cAMP and calcium. PMID: 12502570
    7. This review examines the regulatory features and expression pattern of the SLC8A3 gene which suggest that NCX3 activity could be crucial in neuronal functions such as memory formation and sensory processing. PMID: 15247490
    8. Studies show that both alternatively spliced variants can be translated into protein. PMID: 15777725
    9. The downregulation of the regulator of Ca2+ homeostasis NCX3 by Ca2+-regulated DREAM is a striking example of the autoregulatory property of the Ca2+ signal in neurons. PMID: 16306395

    顯示更多

    收起更多

  • 亞細胞定位：
    Cell membrane; Multi-pass membrane protein. Perikaryon. Cell projection, dendrite. Cell projection, dendritic spine. Cell membrane, sarcolemma. Cytoplasm, sarcoplasm. Cell junction. Mitochondrion outer membrane; Multi-pass membrane protein. Cytoplasm, perinuclear region. Endoplasmic reticulum membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family, SLC8 subfamily
  • 組織特異性：
    Isoform 2 is expressed in brain and skeletal muscle. Isoform 3 is expressed in excitable cells of brain, retina and skeletal muscle. Isoform 4 is expressed in skeletal muscle.
  • 數據庫鏈接：

    HGNC: 11070

    OMIM: 607991

    KEGG: hsa:6547

    STRING: 9606.ENSP00000370669

    UniGene: Hs.337696



主站蜘蛛池模板： 日韩放荡少妇无码视频| 中文 在线 日韩 亚洲 欧美| 成人免费毛片内射美女app| 最近更新中文字幕免费大全| 久久婷婷五月综合97色一本一本 | 免费无码国产欧美久久18| 一本之道高清无码视频| 亚洲国产精品成人精品无码区在线 | 少妇久久久久久被弄到高潮| 少妇高潮流白浆在线观看| 欧美变态另类牲交| 99久e在线精品视频在线| 熟妇高潮精品一区二区三区| 国产亚洲精品久久久网站好莱| 一本之道高清乱码久久久| 隔壁人妻被水电工征服| 国产玉足榨精视频在线观看| 一区二区三区人妻无码| 精品无码中文字幕在线| 丰满的少妇被猛烈进入白浆| 韩国日本三级在线观看| 一本色道久久综合狠狠躁| 亚洲欧美综合精品成人导航| 日本大香伊一区二区三区| 欧美日韩在线第一页免费观看| 国产精品亚洲精品日韩已满十八小| 综合 欧美 小说 另类 图| 日本公妇乱偷中文字幕| 国产丰满老熟女重口对白| 韩国久久久久久级做爰片| 成人一区二区免费视频| 亚洲精品久久久久久一区二区| 日韩成人无码| 国产午夜无码片在线观看影视| 亚洲色欲色欲大片www无码| 无码人妻一区二区三区在线视频| 久久亚洲国产精品影院| 婷婷丁香五月缴情视频| 美女视频黄a视频全免费| 亚洲国产午夜精品理论片妓女| 精品人妻系列无码专区久久|