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SLC52A1 Antibody

  • 中文名稱:
    SLC52A1兔多克隆抗體
  • 貨號:
    CSB-PA977414
  • 規格:
    ¥1100
  • 圖片:
    • The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA977414(SLC52A1 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using CSB-PA977414(SLC52A1 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: ×200)
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
    SLC52A1
  • 別名:
    FLJ10060 antibody; G protein coupled receptor 172B antibody; GPCR antibody; GPCR42 antibody; hRFT1 antibody; member 1 antibody; OTTHUMP00000125300 antibody; PAR2 antibody; PERV-A receptor 2 antibody; PERVA receptor 2 antibody; Porcine endogenous retrovirus A receptor 2 antibody; Protein GPR172B antibody; Putative G protein coupled receptor GPCR42 antibody; Riboflavin transporter 1 antibody; riboflavin transporter antibody; S52A1_HUMAN antibody; SLC52A1 antibody; Solute carrier family 52 antibody; Solute carrier family 52, riboflavin transporter, member 1 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Synthetic peptide of Human SLC52A1
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen affinity purification
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    IHC 1:50-1:200
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Plasma membrane transporter mediating the uptake by cells of the water soluble vitamin B2/riboflavin that plays a key role in biochemical oxidation-reduction reactions of the carbohydrate, lipid, and amino acid metabolism. Humans are unable to synthesize vitamin B2/riboflavin and must obtain it via intestinal absorption.; (Microbial infection) May function as a cell receptor to retroviral envelopes similar to the porcine endogenous retrovirus (PERV-A).
  • 基因功能參考文獻:
    1. We here report a case of transient MADD, caused by a heterozygous intronic variation, c.1134+11G>A, in the SLC52A1 gene encoding RFVT1. This variation creates a binding site for the splice inhibitory hnRNP A1 protein and causes exon 4 skipping. Riboflavin deficiency and maternal malnutrition during pregnancy might have been the determining factor in the outcome of this case. PMID: 29122468
    2. In HT-29 cells, the RFVT1 protein level was drastically lower. In tumor tissues of patients with CRC, RFVT1 content was reduced at both protein and mRNA levels compared to normal mucosa. PMID: 29715086
    3. results are the first to reveal the identity of the minimal SLC52A1 promoter and to establish an important role for Sp-1 in its activity PMID: 25284511
    4. data suggest that MMND is a distinct clinical subgroup of childhood onset MND patients where the known genetic defects are so far negative. PMID: 24139842
    5. summary of recent findings on the cloning, nomenclature, functional characterization and genetic diseases of RFVT1/SLC52A1, RFVT2/SLC52A2 and RFVT3/SLC52A3 [review] PMID: 23506902
    6. Intestinal riboflavin uptake process undergoes differentiation-dependent upregulation and suggest that this is mediated (at least in part) via transcriptional mechanisms of SLC52A1 and SLC52A3. PMID: 23413253
    7. We demonstrated that TFAP-2gamma is one of the transcription factors involved in the PAR-2 expression in human villous trophoblast cells. PMID: 22702469
    8. Identification/characterization riboflavin trasporter (RFT1) as a novel riboflavin transporter. PMID: 18632736

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  • 相關疾病:
    Riboflavin deficiency (RBFVD)
  • 亞細胞定位:
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族:
    Riboflavin transporter family
  • 組織特異性:
    Widely expressed. Highly expressed in the testis, placenta and small intestine. Expressed at lower level in other tissues.
  • 數據庫鏈接:

    HGNC: 30225

    OMIM: 607883

    KEGG: hsa:55065

    STRING: 9606.ENSP00000254853

    UniGene: Hs.632247



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