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Recombinant Human Riboflavin transporter 1 (GPR172B), partial

  • 中文名稱:
    人SLC52A1重組蛋白
  • 貨號:
    CSB-YP878904HU
  • 規格:
  • 來源:
    Yeast
  • 其他:
  • 中文名稱:
    人SLC52A1重組蛋白
  • 貨號:
    CSB-EP878904HU
  • 規格:
  • 來源:
    E.coli
  • 其他:
  • 中文名稱:
    人SLC52A1重組蛋白
  • 貨號:
    CSB-EP878904HU-B
  • 規格:
  • 來源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
    人SLC52A1重組蛋白
  • 貨號:
    CSB-BP878904HU
  • 規格:
  • 來源:
    Baculovirus
  • 其他:
  • 中文名稱:
    人SLC52A1重組蛋白
  • 貨號:
    CSB-MP878904HU
  • 規格:
  • 來源:
    Mammalian cell
  • 其他:

產品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
    SLC52A1
  • Uniprot No.:
  • 別名:
    FLJ10060; G protein coupled receptor 172B; GPCR; GPCR42; hRFT1; member 1; OTTHUMP00000125300; PAR2; PERV-A receptor 2; PERVA receptor 2; Porcine endogenous retrovirus A receptor 2; Protein GPR172B; Putative G protein coupled receptor GPCR42; Riboflavin transporter 1; riboflavin transporter; S52A1_HUMAN; SLC52A1; Solute carrier family 52; Solute carrier family 52, riboflavin transporter, member 1
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    Partial
  • 蛋白標簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Plasma membrane transporter mediating the uptake by cells of the water soluble vitamin B2/riboflavin that plays a key role in biochemical oxidation-reduction reactions of the carbohydrate, lipid, and amino acid metabolism. Humans are unable to synthesize vitamin B2/riboflavin and must obtain it via intestinal absorption.; (Microbial infection) May function as a cell receptor to retroviral envelopes similar to the porcine endogenous retrovirus (PERV-A).
  • 基因功能參考文獻:
    1. We here report a case of transient MADD, caused by a heterozygous intronic variation, c.1134+11G>A, in the SLC52A1 gene encoding RFVT1. This variation creates a binding site for the splice inhibitory hnRNP A1 protein and causes exon 4 skipping. Riboflavin deficiency and maternal malnutrition during pregnancy might have been the determining factor in the outcome of this case. PMID: 29122468
    2. In HT-29 cells, the RFVT1 protein level was drastically lower. In tumor tissues of patients with CRC, RFVT1 content was reduced at both protein and mRNA levels compared to normal mucosa. PMID: 29715086
    3. results are the first to reveal the identity of the minimal SLC52A1 promoter and to establish an important role for Sp-1 in its activity PMID: 25284511
    4. data suggest that MMND is a distinct clinical subgroup of childhood onset MND patients where the known genetic defects are so far negative. PMID: 24139842
    5. summary of recent findings on the cloning, nomenclature, functional characterization and genetic diseases of RFVT1/SLC52A1, RFVT2/SLC52A2 and RFVT3/SLC52A3 [review] PMID: 23506902
    6. Intestinal riboflavin uptake process undergoes differentiation-dependent upregulation and suggest that this is mediated (at least in part) via transcriptional mechanisms of SLC52A1 and SLC52A3. PMID: 23413253
    7. We demonstrated that TFAP-2gamma is one of the transcription factors involved in the PAR-2 expression in human villous trophoblast cells. PMID: 22702469
    8. Identification/characterization riboflavin trasporter (RFT1) as a novel riboflavin transporter. PMID: 18632736

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  • 相關疾病:
    Riboflavin deficiency (RBFVD)
  • 亞細胞定位:
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族:
    Riboflavin transporter family
  • 組織特異性:
    Widely expressed. Highly expressed in the testis, placenta and small intestine. Expressed at lower level in other tissues.
  • 數據庫鏈接:

    HGNC: 30225

    OMIM: 607883

    KEGG: hsa:55065

    STRING: 9606.ENSP00000254853

    UniGene: Hs.632247



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