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  4. SIK3 Antibody

SIK3 Antibody

  • 中文名稱：
    SIK3兔多克隆抗體
  • 貨號：
    CSB-PA008361
  • 規格：
    ￥1090
  • 圖片：
    • Western Blot analysis of LOVO cells using QSK Polyclonal Antibody
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
    SIK3
  • 別名：
    SIK3 antibody; KIAA0999 antibody; QSK antibody; L19Serine/threonine-protein kinase SIK3 antibody; EC 2.7.11.1 antibody; Salt-inducible kinase 3 antibody; SIK-3 antibody; Serine/threonine-protein kinase QSK antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human,Mouse
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human QSK.
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    WB, IHC, ELISA
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    ELISA 1:40000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Positive regulator of mTOR signaling that functions by triggering the degradation of DEPTOR, an mTOR inhibitor. Involved in the dynamic regulation of mTOR signaling in chondrocyte differentiation during skeletogenesis. Negatively regulates cAMP signaling pathway possibly by acting on CRTC2/TORC2 and CRTC3/TORC3. Prevents HDAC4 translocation to the nucleus.
  • 基因功能參考文獻：
    1. role in mediating high salt and IL-17 synergy leading to breast cancer cell proliferation PMID: 28658303
    2. Results found that CpG sites of C1orf106, DMBX1, and SIK3 mediate the genetic risk of psoriasis in Chinese Han population. PMID: 27980695
    3. SIK3 is activated in human osteoarthritic cartilage. PMID: 27009967
    4. Developmental role of Sik3 in hearing and requirement for the maintenance of adult auditory function is reported. PMID: 25060954
    5. SIK3 variants were associated with hypertriglyceridemia in Mexicans. PMID: 24886709
    6. These results establish the importance of SIK3 as a mitotic regulator and underscore the potential of SIK3 as a druggable antimitotic target. PMID: 24743732
    7. cAMP-mediated regulation of SIK3 suggest that SIK3 may mediate some of the effects of this important second messenger in adipocytes PMID: 22588126
    8. Overexpression of SIK3 promotes G1/S cell cycle progression, bestows survival advantages to cancer cells for growth and correlates the clinicopathological conditions of patients with ovarian cancer. PMID: 21399663
    9. Fecal ribosomal protein L19 is a genetic prognostic factor for survival in colorectal cancer. PMID: 18266979

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  • 亞細胞定位：
    Cytoplasm.
  • 蛋白家族：
    Protein kinase superfamily, CAMK Ser/Thr protein kinase family, SNF1 subfamily
  • 組織特異性：
    Expressed in chondrocytes.
  • 數據庫鏈接：

    HGNC: 29165

    OMIM: 614776

    KEGG: hsa:23387

    STRING: 9606.ENSP00000292055

    UniGene: Hs.167451



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