在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. SHFM1 Antibody

SHFM1 Antibody

  • 中文名稱：
    SHFM1兔多克隆抗體
  • 貨號：
    CSB-PA021263GA01HU
  • 規格：
    ￥3,900
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
    SEM1
  • 別名：
    SEM1 antibody; C7orf76 antibody; DSS1 antibody; SHFDG1 antibody; SHFM1 antibody; 26S proteasome complex subunit SEM1 antibody; 26S proteasome complex subunit DSS1 antibody; Deleted in split hand/split foot protein 1 antibody; Split hand/foot deleted protein 1 antibody; Split hand/foot malformation type 1 protein antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human,Mouse,Rat
  • 免疫原：
    Human SHFM1
  • 免疫原種屬：
    Homo sapiens (Human)
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity Purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA,WB,IF
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. Component of the TREX-2 complex (transcription and export complex 2), composed of at least ENY2, GANP, PCID2, SEM1, and either centrin CETN2 or CETN3. The TREX-2 complex functions in docking export-competent ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket). TREX-2 participates in mRNA export and accurate chromatin positioning in the nucleus by tethering genes to the nuclear periphery. Binds and stabilizes BRCA2 and is thus involved in the control of R-loop-associated DNA damage and thus transcription-associated genomic instability. R-loop accumulation increases in SEM1-depleted cells.
  • 基因功能參考文獻：
    1. Promoter methylation plays a role in modulating DSS1 gene expression. Promoter hypomethylation is a frequent event in melanoma and squamous cell carcinoma and is closely linked to poor prognosis. PMID: 27825810
    2. DSS1 is a multifunctional and intrinsically disordered protein. (Review) PMID: 26944332
    3. three phenotypic subregions within the SHFM1 locus link both size and genomic position of the chromosomal aberrations to the clinical variability seen in SHFM1 patients PMID: 26839112
    4. SHFM1 confers cell cycle progression and resistance to p53 stabilizing drugs in gastric cancer cells. PMID: 25697906
    5. by targeting RPA and mimicking DNA, DSS1 functions with BRCA2 in a two-component homologous recombination mediator complex in genome maintenance and tumor suppression PMID: 26145171
    6. Breast cancers with high DSS1 expression have worse prognosis and shorter relapse-free survival times. PMID: 24289229
    7. Mutation screening of the SHFM1 gene in familial breast/ovarian cancer cases. PMID: 23371468
    8. DSS1 protein is critically involved in the maintenance of the transformed phenotype in cervical cancer cells, and that it might be a specific, robust and reliable marker for early detection, diagnosis and trea PMID: 23024267
    9. DSS1 has a role in homologous recombinational repair in human cells PMID: 20817001
    10. p63 binds to an enhancer element in the SHFM1 locus and this element controls expression of DLX6 and DLX5 which are important for limb development. PMID: 20808887
    11. The DSS1 c.143G>A variant is associated with reduced DSS1 expression at RNA and protein levels and altered traffic of the DSS1 protein from the cytoplasm to the nucleus. These alterations could impair DSS1 function and may be implicated in skin cancer. PMID: 20220765
    12. 3.1 angstrom crystal structure of approximately 90-kilodalton BRCA2 domain bound to DSS1, which reveals three oligonucleotide-binding (OB) folds and a helix-turn-helix (HTH) motif PMID: 12228710
    13. DSS1, responsible for autism, was studied in a linkage disequilibrium model. PMID: 17406092
    14. DSS1 has been shown to interact with components of the 26S proteasome in Saccharomyces cerevisiae and in human tumour cells PMID: 17563742
    15. Data suggest that the R3IM motif of DSS1, in conjunction with the complexes of 19S RP and 20S core particle, regulates proteasome interaction through RPN3/S3 molecule, and utilizes a specific subset of poly-ubiquitinated p53 as a substrate. PMID: 18775730

    顯示更多

    收起更多

  • 亞細胞定位：
    Nucleus.
  • 蛋白家族：
    DSS1/SEM1 family
  • 組織特異性：
    Expressed in limb bud, craniofacial primordia and skin.
  • 數據庫鏈接：

    HGNC: 10845

    OMIM: 601285

    STRING: 9606.ENSP00000248566

    UniGene: Hs.489201



主站蜘蛛池模板： 四虎成人精品国产永久免费无码| 久久国产亚洲精品无码| 日本乱理伦片在线观看中文| 强行无套内谢大学生初次| 日韩av影院在线观看| 国内精品视这里只有精品| 东京热无码一区二区三区av| 欧美肥老太牲交大战| 蜜臀av无码人妻精品| 日韩精品久久久肉伦网站| 亚洲欧美成人综合图区| 亚洲精品色情app在线下载观看| 日本精品人妻无码77777| 青草内射中出高潮| 2018亚洲а∨天堂| 欧美精品一产区二产区 | 黄a大片av永久免费| 少妇与黑人一二三区无码| 成年免费视频播放网站推荐| 亚洲精品无码ma在线观看| 久久婷婷五月综合色中文字幕| 中文字幕亚洲无线码一区女同| 久久俺也去丁香综合色| 国产性色αv视频免费| 青草青草久热精品视频在线观看| 久久人人97超碰爱香蕉| 午夜精品影视国产一区在线麻豆 | 69风韵老熟女口爆吞精| 手机在线看永久av片免费| 精品国产乱码久久久人妻| 国产亚洲精品久久久久9999| 亚洲综合久久成人a片| 国产麻豆成人传媒免费观看 | 日日躁夜夜躁白天躁晚上| 国产精品亚洲综合久久系列| 午夜伦费影视在线观看| 亚洲精品永久在线观看| 日韩新无码精品毛片| 亚洲国产成人精品激情姿源 | 亚洲欧美日韩国产手机在线| 精品国产av一区二区三区|