在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. SEM1 Antibody, HRP conjugated

SEM1 Antibody, HRP conjugated

  • 中文名稱：
    SEM1兔多克隆抗體, HRP偶聯
  • 貨號：
    CSB-PA021263LB01HU
  • 規格：
    ￥880
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) SEM1 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    SEM1
  • 別名：
    SEM1 antibody; C7orf76 antibody; DSS1 antibody; SHFDG1 antibody; SHFM1 antibody; 26S proteasome complex subunit SEM1 antibody; 26S proteasome complex subunit DSS1 antibody; Deleted in split hand/split foot protein 1 antibody; Split hand/foot deleted protein 1 antibody; Split hand/foot malformation type 1 protein antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human 26S proteasome complex subunit SEM1 protein (1-70AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    HRP
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. Component of the TREX-2 complex (transcription and export complex 2), composed of at least ENY2, GANP, PCID2, SEM1, and either centrin CETN2 or CETN3. The TREX-2 complex functions in docking export-competent ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket). TREX-2 participates in mRNA export and accurate chromatin positioning in the nucleus by tethering genes to the nuclear periphery. Binds and stabilizes BRCA2 and is thus involved in the control of R-loop-associated DNA damage and thus transcription-associated genomic instability. R-loop accumulation increases in SEM1-depleted cells.
  • 基因功能參考文獻：
    1. Promoter methylation plays a role in modulating DSS1 gene expression. Promoter hypomethylation is a frequent event in melanoma and squamous cell carcinoma and is closely linked to poor prognosis. PMID: 27825810
    2. DSS1 is a multifunctional and intrinsically disordered protein. (Review) PMID: 26944332
    3. three phenotypic subregions within the SHFM1 locus link both size and genomic position of the chromosomal aberrations to the clinical variability seen in SHFM1 patients PMID: 26839112
    4. SHFM1 confers cell cycle progression and resistance to p53 stabilizing drugs in gastric cancer cells. PMID: 25697906
    5. by targeting RPA and mimicking DNA, DSS1 functions with BRCA2 in a two-component homologous recombination mediator complex in genome maintenance and tumor suppression PMID: 26145171
    6. Breast cancers with high DSS1 expression have worse prognosis and shorter relapse-free survival times. PMID: 24289229
    7. Mutation screening of the SHFM1 gene in familial breast/ovarian cancer cases. PMID: 23371468
    8. DSS1 protein is critically involved in the maintenance of the transformed phenotype in cervical cancer cells, and that it might be a specific, robust and reliable marker for early detection, diagnosis and trea PMID: 23024267
    9. DSS1 has a role in homologous recombinational repair in human cells PMID: 20817001
    10. p63 binds to an enhancer element in the SHFM1 locus and this element controls expression of DLX6 and DLX5 which are important for limb development. PMID: 20808887
    11. The DSS1 c.143G>A variant is associated with reduced DSS1 expression at RNA and protein levels and altered traffic of the DSS1 protein from the cytoplasm to the nucleus. These alterations could impair DSS1 function and may be implicated in skin cancer. PMID: 20220765
    12. 3.1 angstrom crystal structure of approximately 90-kilodalton BRCA2 domain bound to DSS1, which reveals three oligonucleotide-binding (OB) folds and a helix-turn-helix (HTH) motif PMID: 12228710
    13. DSS1, responsible for autism, was studied in a linkage disequilibrium model. PMID: 17406092
    14. DSS1 has been shown to interact with components of the 26S proteasome in Saccharomyces cerevisiae and in human tumour cells PMID: 17563742
    15. Data suggest that the R3IM motif of DSS1, in conjunction with the complexes of 19S RP and 20S core particle, regulates proteasome interaction through RPN3/S3 molecule, and utilizes a specific subset of poly-ubiquitinated p53 as a substrate. PMID: 18775730

    顯示更多

    收起更多

  • 亞細胞定位：
    Nucleus.
  • 蛋白家族：
    DSS1/SEM1 family
  • 組織特異性：
    Expressed in limb bud, craniofacial primordia and skin.
  • 數據庫鏈接：

    HGNC: 10845

    OMIM: 601285

    STRING: 9606.ENSP00000248566

    UniGene: Hs.489201



主站蜘蛛池模板： 久久无码人妻一区二区三区午夜| 黑人大群体交免费视频| 狂野欧美性猛交xxxx| 丁香激情综合久久伊人久久| 亚洲va中文字幕| 男女性杂交内射女bbwxz| 夜夜躁狠狠躁2021| 国产精品无码专区在线观看 | 老熟妻内射精品一区| 亚洲乱码无人区卡1卡2卡3| 国产天美传媒性色av出轨| 丰满人妻无奈张开双腿av| 久久精品国产2020| 无码日韩精品一区二区免费暖暖| 中文字幕美人妻亅u乚一596| 精品国产一区二区三区av性色 | 国产午夜精品无码| 丰满的人妻hd高清日本| 久久青青草原国产毛片| 男女啪啪无遮挡免费网站| 免费无码又爽又刺激成人| 亚洲精品久久久久一区二区三区| 无码少妇一区二区性色av| 国产精品毛片无遮挡高清| 亚洲伊人色欲综合网| 国内高清久久久久久| 97人妻免费碰视频碰免| 国产黑色丝袜视频在线观看网红| 综合偷自拍亚洲乱中文字幕 | av无码免费永久在线观看| 亚洲人成影院在线观看| 精品一区二区三区东京热| 欧美成人h亚洲综合在线观看| 高清国产亚洲欧洲av综合一区| 亚洲色无码中文字幕在线| 四虎永久在线精品免费一区二区| 妺妺窝人体色www在线下载| 色播亚洲视频在线观看| 三上悠亚的av片在线无码| 日本亚洲欧洲另类图片| 九九热爱视频精品视频16|