在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. SHANK2 Antibody

SHANK2 Antibody

  • 中文名稱：
    SHANK2兔多克隆抗體
  • 貨號：
    CSB-PA892492LA01HU
  • 規格：
    ￥440
  • 圖片：
    • IHC image of CSB-PA892492LA01HU diluted at 1:400 and staining in paraffin-embedded human cervical cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
    • IHC image of CSB-PA892492LA01HU diluted at 1:400 and staining in paraffin-embedded human liver cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) SHANK2 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    SHANK2 antibody; CORTBP1 antibody; KIAA1022 antibody; PROSAP1 antibody; SH3 and multiple ankyrin repeat domains protein 2 antibody; Shank2 antibody; Cortactin-binding protein 1 antibody; CortBP1 antibody; Proline-rich synapse-associated protein 1 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human SH3 and multiple ankyrin repeat domains protein 2 protein (728-822AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated

    本頁面中的產品，SHANK2 Antibody (CSB-PA892492LA01HU)，的標記方式是Non-conjugated。對于SHANK2 Antibody，我們還提供其他標記。見下表：

    可提供標記
    標記方式 貨號 產品名稱 應用
    HRP CSB-PA892492LB01HU SHANK2 Antibody, HRP conjugated ELISA
    FITC CSB-PA892492LC01HU SHANK2 Antibody, FITC conjugated
    Biotin CSB-PA892492LD01HU SHANK2 Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:200-1:500
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Seems to be an adapter protein in the postsynaptic density (PSD) of excitatory synapses that interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors, and the actin-based cytoskeleton. May play a role in the structural and functional organization of the dendritic spine and synaptic junction.
  • 基因功能參考文獻：
    1. We report a deletion including the SHANK2 gene in a female child with dysmorphic features, microcephaly, and global developmental delay, providing additional evidence for SHANK2 involvement in intellectual disability PMID: 28211979
    2. In one family, seven siblings with schizophrenia spectrum disorders each carry a novel private missense variant within the SHANK2 gene. PMID: 27001614
    3. The present study demonstrated that depletion of SHANK2 inhibited the osteo/dentinogenic differentiation potentials in human stem cells from apical papilla PMID: 27641545
    4. variants in the SHANK2 gene in a schizophrenia patient cohort PMID: 25560758
    5. Knockdown of endogenous Shank2E or overexpression of a dominant-negative Shank2E mutant inhibited the glucocorticoid-mediated increase in CFTR. PMID: 24811177
    6. syndapin I functions reflected direct, SH3 domain-mediated associations and functional interactions with ProSAP1/Shank2. PMID: 24751538
    7. Lack of association between NLGN3, NLGN4, SHANK2 and SHANK3 gene variants and autism spectrum disorder in a Chinese population. PMID: 23468870
    8. deletion of ProSAP1/Shank2 results in an early, brain-region-specific upregulation of ionotropic glutamate receptors at the synapse and increased levels of ProSAP2/Shank3 PMID: 22699619
    9. we confirmed that de novo SHANK2 deletions are present in patients with ASD and showed that several SHANK2 variants reduce the number of synapses in vitro PMID: 22346768
    10. dominant negative effect translates into dose-dependent altered cognitive behavior of SHANK2-R462X-expressing mice, with an impact on the penetrance of ASD PMID: 21994763
    11. we identified de novo copy number variations in the SHANK2 synaptic scaffolding gene in two unrelated individuals with autism-spectrum disorder (ASD) and mental retardation PMID: 20473310
    12. betaPix up-regulates NHE3 membrane expression and activity by Shank2-mediated protein-protein interaction and by activating Rho GTPases in the apical regions of epithelial cells PMID: 20080968
    13. Shank2 increased the membrane expression and basal activity of NHE3 and attenuated the cAMP-dependent inhibition of NHE3 activity. PMID: 16293618

    顯示更多

    收起更多

  • 相關疾病：
    Autism 17 (AUTS17)
  • 亞細胞定位：
    Apical cell membrane. Cytoplasm. Cell junction, synapse. Cell junction, synapse, postsynaptic density. Cell projection, growth cone. Cell projection, dendritic spine.
  • 蛋白家族：
    SHANK family
  • 組織特異性：
    Isoform 3 is present in epithelial colonic cells (at protein level).
  • 數據庫鏈接：

    HGNC: 14295

    OMIM: 603290

    KEGG: hsa:22941

    STRING: 9606.ENSP00000345193

    UniGene: Hs.268726



主站蜘蛛池模板： 免费观看黄网站在线播放| 久久久久久国产精品无码超碰 | 人妻激情偷乱一区二区三区| 欧美级特黄aaaaaa片| 人妻熟女久久久久久久| 国产精品videossex国产高清| 日本最新免费二区三区| 成人区精品一区二区不卡| 乱无码伦视频在线观看| 国产成人亚洲综合无码| 亚洲免费人成在线视频观看| 大香线蕉伊人精品超碰| 日韩欧美国产一区精品| 国产高清无密码一区二区三区 | 久久综合九色综合网站| 天天狠天天天天透在线 | 国产精品久久人妻互换| 风韵多水的老熟妇| 日韩丰满少妇无吗视频激情内射| 无码精品国产一区二区免费| 男女做爰猛烈叫床视频动态图| 少妇高潮一区二区三区99| 少妇高清精品毛片在线视频| 国产超碰人人爽人人做av| av 日韩 人妻 黑人 综合 无码| 少妇极品熟妇人妻无码| 国产成人无码a区在线| 真人啪啪高潮喷水呻吟无遮挡| 无码丰满熟妇juliaann与黑人| 亚洲欧美日韩中文无线码| 久久久久99精品成人品| 精品人妻人人做人人爽夜夜爽| 久久久精品国产sm最大网站| 亚洲韩国日本高清一区| 2020精品国产户外| 久久精品中文字幕无码绿巨人| 在线不卡日本v二区到六区| 综合色一色综合久久网| 精品国产人妻一区二区三区| 天天看片视频免费观看| 亚洲国产aⅴ综合网|