在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. SHANK2 Antibody

SHANK2 Antibody

  • 中文名稱：
    SHANK2兔多克隆抗體
  • 貨號：
    CSB-PA008288
  • 規格：
    ￥1090
  • 圖片：
    • Western Blot analysis of RAW264.7 cells using Shank 2 Polyclonal Antibody
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
  • 別名：
    SHANK2 antibody; CORTBP1 antibody; KIAA1022 antibody; PROSAP1 antibody; SH3 and multiple ankyrin repeat domains protein 2 antibody; Shank2 antibody; Cortactin-binding protein 1 antibody; CortBP1 antibody; Proline-rich synapse-associated protein 1 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human Shank 2.
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    WB, ELISA
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:2000
    ELISA 1:20000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Seems to be an adapter protein in the postsynaptic density (PSD) of excitatory synapses that interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors, and the actin-based cytoskeleton. May play a role in the structural and functional organization of the dendritic spine and synaptic junction.
  • 基因功能參考文獻：
    1. We report a deletion including the SHANK2 gene in a female child with dysmorphic features, microcephaly, and global developmental delay, providing additional evidence for SHANK2 involvement in intellectual disability PMID: 28211979
    2. In one family, seven siblings with schizophrenia spectrum disorders each carry a novel private missense variant within the SHANK2 gene. PMID: 27001614
    3. The present study demonstrated that depletion of SHANK2 inhibited the osteo/dentinogenic differentiation potentials in human stem cells from apical papilla PMID: 27641545
    4. variants in the SHANK2 gene in a schizophrenia patient cohort PMID: 25560758
    5. Knockdown of endogenous Shank2E or overexpression of a dominant-negative Shank2E mutant inhibited the glucocorticoid-mediated increase in CFTR. PMID: 24811177
    6. syndapin I functions reflected direct, SH3 domain-mediated associations and functional interactions with ProSAP1/Shank2. PMID: 24751538
    7. Lack of association between NLGN3, NLGN4, SHANK2 and SHANK3 gene variants and autism spectrum disorder in a Chinese population. PMID: 23468870
    8. deletion of ProSAP1/Shank2 results in an early, brain-region-specific upregulation of ionotropic glutamate receptors at the synapse and increased levels of ProSAP2/Shank3 PMID: 22699619
    9. we confirmed that de novo SHANK2 deletions are present in patients with ASD and showed that several SHANK2 variants reduce the number of synapses in vitro PMID: 22346768
    10. dominant negative effect translates into dose-dependent altered cognitive behavior of SHANK2-R462X-expressing mice, with an impact on the penetrance of ASD PMID: 21994763
    11. we identified de novo copy number variations in the SHANK2 synaptic scaffolding gene in two unrelated individuals with autism-spectrum disorder (ASD) and mental retardation PMID: 20473310
    12. betaPix up-regulates NHE3 membrane expression and activity by Shank2-mediated protein-protein interaction and by activating Rho GTPases in the apical regions of epithelial cells PMID: 20080968
    13. Shank2 increased the membrane expression and basal activity of NHE3 and attenuated the cAMP-dependent inhibition of NHE3 activity. PMID: 16293618

    顯示更多

    收起更多

  • 相關疾病：
    Autism 17 (AUTS17)
  • 亞細胞定位：
    Apical cell membrane. Cytoplasm. Cell junction, synapse. Cell junction, synapse, postsynaptic density. Cell projection, growth cone. Cell projection, dendritic spine.
  • 蛋白家族：
    SHANK family
  • 組織特異性：
    Isoform 3 is present in epithelial colonic cells (at protein level).
  • 數據庫鏈接：

    HGNC: 14295

    OMIM: 603290

    KEGG: hsa:22941

    STRING: 9606.ENSP00000345193

    UniGene: Hs.268726



主站蜘蛛池模板： 在线中文新版最新版在线| 久久精品日韩av无码| 精品国产一区二区三区无码| 中文字幕乱码亚洲无线三区| 久久精品人妻一区二区蜜桃| 久久www香蕉免费人成| 2020精品国产视| 欧美人与禽z0zo牲伦交| 国产精品va无码免费| 男阳茎进女阳道视频大全| 无码专区—va亚洲v专区vr| 亚洲成αv人片在线观看| 伊人久久精品无码av一区| 高潮喷水的毛片| 无码人妻啪啪一区二区| 国产一区二区三区免费高清在线播放| 女人与牲口性恔配视频免费| 久久久久人妻一区精品果冻| 精品综合久久久久久888蜜芽| 久久精品丝袜高跟鞋| 一区二区三区高清日本vr| 久在线视视频在线观看| 青青草原综合久久大伊人精品 | 国产精品综合一区二区三区| 中文字字幕乱码视频高清| 色中色成人导航| 天堂va蜜桃一区二区三区| 美女mm131爽爽爽作爱| 熟女丝袜潮喷内裤视频网站| 一区二区三区无码高清视频| 亚洲熟悉妇女xxx妇女av| 天天爱天天做天天爽夜夜揉| 岛国在线无码高清视频| 欧美精品黑人粗大视频| 麻豆国产97在线 | 欧美| 亚洲综合无码中文字幕第2页| 国产亚洲精品第一综合另类| 美女大量吞精在线观看456| 亚洲人成影院在线无码按摩店 | 人妻精品制服丝袜久久久| h人成在线看免费视频|