在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. SH3RF1 Antibody

SH3RF1 Antibody

  • 中文名稱：
    SH3RF1兔多克隆抗體
  • 貨號：
    CSB-PA773800LA01HU
  • 規格：
    ￥440
  • 圖片：
    • Immunofluorescence staining of Hela cells with CSB-PA773800LA01HU at 1:200, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) SH3RF1 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    SH3RF1
  • 別名：
    SH3RF1 antibody; KIAA1494 antibody; POSH antibody; POSH1 antibody; RNF142 antibody; SH3MD2 antibody; E3 ubiquitin-protein ligase SH3RF1 antibody; EC 2.3.2.27 antibody; Plenty of SH3s antibody; Protein POSH antibody; RING finger protein 142 antibody; RING-type E3 ubiquitin transferase SH3RF1 antibody; SH3 domain-containing RING finger protein 1 antibody; SH3 multiple domains protein 2 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human E3 ubiquitin-protein ligase SH3RF1 protein (628-742AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated

    本頁面中的產品，SH3RF1 Antibody (CSB-PA773800LA01HU)，的標記方式是Non-conjugated。對于SH3RF1 Antibody，我們還提供其他標記。見下表：

    可提供標記
    標記方式 貨號 產品名稱 應用
    HRP CSB-PA773800LB01HU SH3RF1 Antibody, HRP conjugated ELISA
    FITC CSB-PA773800LC01HU SH3RF1 Antibody, FITC conjugated
    Biotin CSB-PA773800LD01HU SH3RF1 Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, IF
  • 推薦稀釋比：
    Application Recommended Dilution
    IF 1:200-1:500
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Has E3 ubiquitin-protein ligase activity. In the absence of an external substrate, it can catalyze self-ubiquitination. Stimulates ubiquitination of potassium channel KCNJ1, enhancing it's dynamin-dependent and clathrin-independent endocytosis. Acts as a scaffold protein that coordinates with MAPK8IP1/JIP1 in organizing different components of the JNK pathway, including RAC1 or RAC2, MAP3K11/MLK3 or MAP3K7/TAK1, MAP2K7/MKK7, MAPK8/JNK1 and/or MAPK9/JNK2 into a functional multiprotein complex to ensure the effective activation of the JNK signaling pathway. Regulates the differentiation of CD4(+) and CD8(+) T-cells and promotes T-helper 1 (Th1) cell differentiation. Regulates the activation of MAPK8/JNK1 and MAPK9/JNK2 in CD4(+) T-cells and the activation of MAPK8/JNK1 in CD8(+) T-cells. Plays a crucial role in the migration of neocortical neurons in the developing brain. Controls proper cortical neuronal migration and the formation of proximal cytoplasmic dilation in the leading process (PCDLP) in migratory neocortical neurons by regulating the proper localization of activated RAC1 and F-actin assembly.; (Microbial infection) Plays an essential role in the targeting of HIV-1 Gag to the plasma membrane, this function is dependent on it's RING domain, and hence it's E3 ligase activity.
  • 基因功能參考文獻：
    1. These results show that POSH plays a critical role in the progression of epileptic seizures via N-methyl-D-aspartate receptor trafficking PMID: 29057721
    2. Data show that the two N-terminal SH3 domains of SH3 domain containing ring finger 1 (SH3RF1) protein interact with FAT1 protein. PMID: 28129444
    3. We found a genome-wide significant association for rs2282987 in CDK6 and a consistent association for rs2706748 in SH3RF1 . PMID: 23644744
    4. The data presented here define POSH and Siah2 as important mediators of death receptor mediated apoptosis and suggest targeting the interaction of these two E3 ligases is a promising novel cancer therapeutic strategy. PMID: 21586138
    5. POSH promotes cell survival in Drosophila and in human rheumatoid arthritis synovial fibroblasts PMID: 20974134
    6. POSH disassociates from the JNK complex after phosphorylation of MLK3 by Akt2, which leads to down-regulation of the JNK signaling pathway PMID: 14504284
    7. A previously undescribed step in HIV biogenesis that suggests a direct function for hPOSH-mediated ubiquitination in protein sorting at the trans-Golgi network. PMID: 15659549
    8. Results identified ALIX as an ubiquitination substrate of POSH and indicate that POSH and ALIX cooperate to facilitate efficient virus release. PMID: 19393081
    9. POSH inhibits ROMK channels by enhancing dynamin-dependent and clathrin-independent endocytosis and by stimulating ubiquitination of ROMK channels. PMID: 19710010
    10. This publication pertains to studies in mice. PMID: 9482736

    顯示更多

    收起更多

  • 亞細胞定位：
    Cytoplasm, perinuclear region. Cell projection, lamellipodium. Golgi apparatus, trans-Golgi network.
  • 蛋白家族：
    SH3RF family
  • 數據庫鏈接：

    HGNC: 17650

    KEGG: hsa:57630

    STRING: 9606.ENSP00000284637

    UniGene: Hs.301804



主站蜘蛛池模板： 国产小受呻吟gv视频在线观看| 日韩精品一区二区三区在线观看l| 酒店大战丝袜高跟鞋人妻| 欲香欲色天天天综合和网| 欧美黑人与白人精品a片| 麻豆成人久久精品二区三区免费| 国产亚洲视频在线观看网址| 两性色午夜视频免费无码| 久久精品国产亚洲7777| 亚洲成av人综合在线观看| √8天堂资源地址中文在线| 亚洲精品色播一区二区| 动漫精品中文无码卡通动漫| 国产边打电话边被躁视频| 99精品免费久久久久久久久日本| 熟女俱乐部五十路六十路av| 亚洲gv永久无码天堂网| 国产草莓视频无码a在线观看| 国产在线一区二区香蕉 在线| 欧美牲交a欧美牲交aⅴ免费真| 国产 一二三四五六| 国产色青青视频在线观看撒| 国产成人久久久精品二区三区| 国产草草影院ccyycom| 国产亚洲精品美女久久久久 | 中国精品少妇hd| 又大又粗又爽的少妇免费视频| 欧美日激情日韩精品嗯| 免费国产va在线观看中文字| 午夜福利精品导航凹凸| 国模吧无码一区二区三区| 久久伊人五月丁香狠狠色| 伊人久久大香线蕉综合直播| 偷自拍亚洲视频在线观看99| 日产精品久久久久久久| 少妇太爽了在线观看| 美女内射毛片在线看免费人动物| 国产性猛交普通话对白| 日射精情感性色视频| 噜噜久久噜噜久久鬼88 | 国产精品白丝喷水在线观看 |