在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. SH3RF1 Antibody, Biotin conjugated

SH3RF1 Antibody, Biotin conjugated

  • 中文名稱：
    SH3RF1兔多克隆抗體, Biotin偶聯
  • 貨號：
    CSB-PA773800LD01HU
  • 規格：
    ￥880
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) SH3RF1 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    SH3RF1
  • 別名：
    SH3RF1 antibody; KIAA1494 antibody; POSH antibody; POSH1 antibody; RNF142 antibody; SH3MD2 antibody; E3 ubiquitin-protein ligase SH3RF1 antibody; EC 2.3.2.27 antibody; Plenty of SH3s antibody; Protein POSH antibody; RING finger protein 142 antibody; RING-type E3 ubiquitin transferase SH3RF1 antibody; SH3 domain-containing RING finger protein 1 antibody; SH3 multiple domains protein 2 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human E3 ubiquitin-protein ligase SH3RF1 protein (628-742AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Biotin
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Has E3 ubiquitin-protein ligase activity. In the absence of an external substrate, it can catalyze self-ubiquitination. Stimulates ubiquitination of potassium channel KCNJ1, enhancing it's dynamin-dependent and clathrin-independent endocytosis. Acts as a scaffold protein that coordinates with MAPK8IP1/JIP1 in organizing different components of the JNK pathway, including RAC1 or RAC2, MAP3K11/MLK3 or MAP3K7/TAK1, MAP2K7/MKK7, MAPK8/JNK1 and/or MAPK9/JNK2 into a functional multiprotein complex to ensure the effective activation of the JNK signaling pathway. Regulates the differentiation of CD4(+) and CD8(+) T-cells and promotes T-helper 1 (Th1) cell differentiation. Regulates the activation of MAPK8/JNK1 and MAPK9/JNK2 in CD4(+) T-cells and the activation of MAPK8/JNK1 in CD8(+) T-cells. Plays a crucial role in the migration of neocortical neurons in the developing brain. Controls proper cortical neuronal migration and the formation of proximal cytoplasmic dilation in the leading process (PCDLP) in migratory neocortical neurons by regulating the proper localization of activated RAC1 and F-actin assembly.; (Microbial infection) Plays an essential role in the targeting of HIV-1 Gag to the plasma membrane, this function is dependent on it's RING domain, and hence it's E3 ligase activity.
  • 基因功能參考文獻：
    1. These results show that POSH plays a critical role in the progression of epileptic seizures via N-methyl-D-aspartate receptor trafficking PMID: 29057721
    2. Data show that the two N-terminal SH3 domains of SH3 domain containing ring finger 1 (SH3RF1) protein interact with FAT1 protein. PMID: 28129444
    3. We found a genome-wide significant association for rs2282987 in CDK6 and a consistent association for rs2706748 in SH3RF1 . PMID: 23644744
    4. The data presented here define POSH and Siah2 as important mediators of death receptor mediated apoptosis and suggest targeting the interaction of these two E3 ligases is a promising novel cancer therapeutic strategy. PMID: 21586138
    5. POSH promotes cell survival in Drosophila and in human rheumatoid arthritis synovial fibroblasts PMID: 20974134
    6. POSH disassociates from the JNK complex after phosphorylation of MLK3 by Akt2, which leads to down-regulation of the JNK signaling pathway PMID: 14504284
    7. A previously undescribed step in HIV biogenesis that suggests a direct function for hPOSH-mediated ubiquitination in protein sorting at the trans-Golgi network. PMID: 15659549
    8. Results identified ALIX as an ubiquitination substrate of POSH and indicate that POSH and ALIX cooperate to facilitate efficient virus release. PMID: 19393081
    9. POSH inhibits ROMK channels by enhancing dynamin-dependent and clathrin-independent endocytosis and by stimulating ubiquitination of ROMK channels. PMID: 19710010
    10. This publication pertains to studies in mice. PMID: 9482736

    顯示更多

    收起更多

  • 亞細胞定位：
    Cytoplasm, perinuclear region. Cell projection, lamellipodium. Golgi apparatus, trans-Golgi network.
  • 蛋白家族：
    SH3RF family
  • 數據庫鏈接：

    HGNC: 17650

    KEGG: hsa:57630

    STRING: 9606.ENSP00000284637

    UniGene: Hs.301804



主站蜘蛛池模板： 老色鬼在线精品视频| 亚洲精品欧美精品日韩精品| 久久视频这里只精品99| www.一区二区三区在线 | 欧洲| 狠狠色婷婷久久综合频道毛片| 激情综合五月| 国产 高潮 抽搐 正在播放 | 风韵多水的老熟妇| 玩弄japan白嫩少妇hd| 最新版天堂资源中文官网| 免费无码黄十八禁网站在线观看 | 久久精品国产免费观看| 国产高清japanese在线播放e| 午夜内射中出视频| 久久无码高潮喷水| 特级无码毛片免费视频| 久久精品无码一区二区app| 亚洲日韩一中文字暮av| 男男车车的车车网站w98免费| 少妇愉情理伦片高潮日本| 久久婷婷大香萑太香蕉av人| 亚洲欧美国产免费综合视频| 日产精品一区二区| 亚洲图片自拍偷图区| 国产理论剧情大片在线播放| 伊人久久综合色| 久久综合久久美利坚合众国| 中文字幕+乱码+中文乱码www| 成人午夜亚洲精品无码区| 少妇扒开粉嫩小泬视频| 午夜影视啪啪免费体验区入口 | 免费国产黄线在线观看| 极品少妇被啪到呻吟喷水| 97视频精品全国免费观看| 99久久精品费精品国产一区二| 国产成a人亚洲精v品无码性色| 最近免费中文字幕大全免费版视频| 国产午夜亚洲精品一区| 内射人妻无码色ab麻豆| 中文字幕无码中文字幕有码| 天天狠天天透天干天天|