在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

SH3GL2 Antibody

  • 中文名稱:
    SH3GL2兔多克隆抗體
  • 貨號:
    CSB-PA050049
  • 規(guī)格:
    ¥1090
  • 其他:

產(chǎn)品詳情

  • Uniprot No.:
  • 基因名:
  • 別名:
    bA335L15.1 (SH3 domain GRB2 like 2) antibody; CNSA2 antibody; EEN B1 antibody; EEN-B1 antibody; Endophilin 1 antibody; Endophilin A1 antibody; Endophilin A1 BAR domain antibody; Endophilin-1 antibody; Endophilin-A1 antibody; FLJ20276 antibody; FLJ25015 antibody; OTTHUMP00000021084 antibody; SH3 domain containing GRB2 like protein 2 antibody; SH3 domain GRB2 like 2 antibody; SH3 domain protein 2A antibody; SH3 domain-containing GRB2-like protein 2 antibody; SH3D2A antibody; SH3G2_HUMAN antibody; Sh3gl2 antibody; Sh3p4 antibody; SH3PA antibody
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human,Mouse,Rat
  • 免疫原:
    Synthesized peptide derived from the Internal region of Human Endophilin I.
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產(chǎn)品提供形式:
    Liquid
  • 應(yīng)用范圍:
    WB, ELISA
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:2000
    ELISA 1:10000
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能:
    Implicated in synaptic vesicle endocytosis. May recruit other proteins to membranes with high curvature. Required for BDNF-dependent dendrite outgrowth. Cooperates with SH3GL2 to mediate BDNF-NTRK2 early endocytic trafficking and signaling from early endosomes.
  • 基因功能參考文獻:
    1. The results suggest that SH3GL2 suppresses migration and invasion behaviors of glioma cells through negatively regulating STAT3/MMP2 signaling. PMID: 28470949
    2. Alix acts in concert with endophilin A to promote clathrin-independent endocytosis of cholera toxin and to regulate cell migration. PMID: 27244115
    3. This study identified a new mitochondria reprogramming pathway influencing breast cancer progression through SH3GL2 and MFN2. These proteins were frequently lost in breast cancer, which was traceable in the circulating exosomes. PMID: 26888829
    4. Endophilin-1 was a direct and functional downstream target of miR-107. PMID: 27038654
    5. Methylation status of SH3GL2 gene was associated with the TNM staging and HPV infection status of vulvar squamous cell carcinoma. PMID: 26823912
    6. Endophilin-1 positively regulated blood-brain barrier permeability via the EGFR-JNK signaling pathway in hCMEC/D3 cells, which would provide an experimental basis for further research on endophilin-1 mediated the opening of blood-brain barrier . PMID: 25721793
    7. these results reveal a novel function of postsynaptic endophilin A1 in spine morphogenesis, stabilization and synaptic function through the regulation of p140Cap PMID: 25771685
    8. Data indicate that the presence of the susceptible G allele in SNP rs1049430 is associated with the inactivation of SH3-domain GRB2-like 2 protein (SH3GL2) and could be used as a prognostic marker of head and neck squamous cell carcinoma (HNSCC). PMID: 25728707
    9. study described that endophilin-1 is expressed in hCMEC/D3 cells where it regulates the permeability of blood-brain barrier by altering the expression of ZO-1 and occludin via the EGFR-ERK1/2 pathway PMID: 24854121
    10. miR-330 negatively regulated the expression of SH3GL2 in GSCs, which promoted the oncogenic progression of GSCs through activating ERK and PI3K/AKT signaling pathways. PMID: 24736727
    11. these findings identify loss of Sh3gl2 as a frequent event in Urothelial carcinoma (UC) development that promotes disease progression. PMID: 23814487
    12. this study suggests a novel mechanism in which Lpd mediates EGFR endocytosis via Mena downstream of endophilin. PMID: 24076656
    13. Overexpression of EGFR in head and neck squamous cell carcinoma is associated with inactivation of SH3GL2 and CDC25A genes. PMID: 23675485
    14. Data suggest that expression of endothelin-1 and vWF (von Willebrand factor) is up-regulated and eNOS (endothelial nitric oxide synthase) activity is increased in radial artery in diabetic patients with coronary artery disease. PMID: 22972845
    15. Our results indicate that SH3GL2 is frequently deleted in NSCLC and regulates cellular growth and invasion by modulating EGFR function. PMID: 22968441
    16. SH3GL2 gene was identified as the target of miR-330. miRNA-330 plays an oncogenic role in human glioblastoma by regulating SH3GL2 gene and might be a new therapeutic target of human glioblastoma. PMID: 23029364
    17. simulations constitute a multi-dimensional exploration of how EGF-dependent EGFR endocytosis and ERK activation are dynamically affected by scaffolds KSR and MP1, co-regulated by Cbl-CIN85 and Endophilin A1 PMID: 21829671
    18. Alterations of SH3GL2 and CDKN2A loci have a synergistic role in the development of early-onset breast cancer. PMID: 18239974

    顯示更多

    收起更多

  • 亞細胞定位:
    Cytoplasm. Membrane; Peripheral membrane protein. Early endosome. Cell junction, synapse, presynapse.
  • 蛋白家族:
    Endophilin family
  • 組織特異性:
    Brain, mostly in frontal cortex. Expressed at high level in fetal cerebellum.
  • 數(shù)據(jù)庫鏈接:

    HGNC: 10831

    OMIM: 604465

    KEGG: hsa:6456

    STRING: 9606.ENSP00000369981

    UniGene: Hs.743740



主站蜘蛛池模板: 国产熟妇搡bbbb搡bbbb| 亚洲国产精品无码久久秋霞| 99久久国产综合精品五月天| 国产后入又长又硬| 人妻内射一区二区在线视频| 国产xxxx69真实实拍| 女人被男人桶30分钟无遮挡动态图| 午夜无码片在线观看影院y | 四库影院永久国产精品| 亚洲精品久久国产精品| 国产草草影院ccyycom| 国产女主播白浆在线观看| 国产 高潮 抽搐 正在播放| 亚洲男人成人性天堂网站| 97在线观看播放| 精品无码久久久久久久久久| av天堂永久资源网| 中文字幕无码专区一va亚洲v专区在线 | 免费看成人aa片无码视频羞羞网| 久久久久久久女国产乱让韩| 精品香蕉久久久午夜福利| 牲交a欧美牲交aⅴ免费一| 亚洲成av 人片在线观看无码| 精品国产福利久久久| 成人免费大片黄在线观看com| 夜夜躁很很躁日日躁麻豆| 无码国产乱人伦偷精品视频| 亚洲精品国产品国语原创| 亚洲欧美日韩中文在线制服| 天堂8在线新版官网| 国产精品白浆在线观看免费 | 中国娇小与黑人巨大交| 日韩一本之道一区中文字幕| 国产素人在线观看人成视频 | 女人的天堂a国产在线观看 | 国产偷抇久久精品a片69| 国产精品美女久久久浪潮av | 巨大乳女人做爰视频在线看| 人妻熟女一区二区aⅴ千叶宁真| 日本在线看片免费人成视频1000| 国产超碰人人爽人人做av|