在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

SH3GL2 Antibody

  • 中文名稱:
    SH3GL2兔多克隆抗體
  • 貨號(hào):
    CSB-PA278079
  • 規(guī)格:
    ¥2024
  • 圖片:
    • Western blot analysis of extracts from K562 cells and HeLa cells, using SH3GL2 antibody.
  • 其他:

產(chǎn)品詳情

  • 產(chǎn)品名稱:
    Rabbit anti-Homo sapiens (Human) SH3GL2 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human
  • 免疫原:
    Synthesized peptide derived from internal of Human SH3GL2.
  • 免疫原種屬:
    Homo sapiens (Human)
  • 克隆類型:
    Polyclonal
  • 純化方式:
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 產(chǎn)品提供形式:
    Liquid
  • 應(yīng)用范圍:
    ELISA,WB
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:3000
  • Protocols:
  • 儲(chǔ)存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能:
    Implicated in synaptic vesicle endocytosis. May recruit other proteins to membranes with high curvature. Required for BDNF-dependent dendrite outgrowth. Cooperates with SH3GL2 to mediate BDNF-NTRK2 early endocytic trafficking and signaling from early endosomes.
  • 基因功能參考文獻(xiàn):
    1. The results suggest that SH3GL2 suppresses migration and invasion behaviors of glioma cells through negatively regulating STAT3/MMP2 signaling. PMID: 28470949
    2. Alix acts in concert with endophilin A to promote clathrin-independent endocytosis of cholera toxin and to regulate cell migration. PMID: 27244115
    3. This study identified a new mitochondria reprogramming pathway influencing breast cancer progression through SH3GL2 and MFN2. These proteins were frequently lost in breast cancer, which was traceable in the circulating exosomes. PMID: 26888829
    4. Endophilin-1 was a direct and functional downstream target of miR-107. PMID: 27038654
    5. Methylation status of SH3GL2 gene was associated with the TNM staging and HPV infection status of vulvar squamous cell carcinoma. PMID: 26823912
    6. Endophilin-1 positively regulated blood-brain barrier permeability via the EGFR-JNK signaling pathway in hCMEC/D3 cells, which would provide an experimental basis for further research on endophilin-1 mediated the opening of blood-brain barrier . PMID: 25721793
    7. these results reveal a novel function of postsynaptic endophilin A1 in spine morphogenesis, stabilization and synaptic function through the regulation of p140Cap PMID: 25771685
    8. Data indicate that the presence of the susceptible G allele in SNP rs1049430 is associated with the inactivation of SH3-domain GRB2-like 2 protein (SH3GL2) and could be used as a prognostic marker of head and neck squamous cell carcinoma (HNSCC). PMID: 25728707
    9. study described that endophilin-1 is expressed in hCMEC/D3 cells where it regulates the permeability of blood-brain barrier by altering the expression of ZO-1 and occludin via the EGFR-ERK1/2 pathway PMID: 24854121
    10. miR-330 negatively regulated the expression of SH3GL2 in GSCs, which promoted the oncogenic progression of GSCs through activating ERK and PI3K/AKT signaling pathways. PMID: 24736727
    11. these findings identify loss of Sh3gl2 as a frequent event in Urothelial carcinoma (UC) development that promotes disease progression. PMID: 23814487
    12. this study suggests a novel mechanism in which Lpd mediates EGFR endocytosis via Mena downstream of endophilin. PMID: 24076656
    13. Overexpression of EGFR in head and neck squamous cell carcinoma is associated with inactivation of SH3GL2 and CDC25A genes. PMID: 23675485
    14. Data suggest that expression of endothelin-1 and vWF (von Willebrand factor) is up-regulated and eNOS (endothelial nitric oxide synthase) activity is increased in radial artery in diabetic patients with coronary artery disease. PMID: 22972845
    15. Our results indicate that SH3GL2 is frequently deleted in NSCLC and regulates cellular growth and invasion by modulating EGFR function. PMID: 22968441
    16. SH3GL2 gene was identified as the target of miR-330. miRNA-330 plays an oncogenic role in human glioblastoma by regulating SH3GL2 gene and might be a new therapeutic target of human glioblastoma. PMID: 23029364
    17. simulations constitute a multi-dimensional exploration of how EGF-dependent EGFR endocytosis and ERK activation are dynamically affected by scaffolds KSR and MP1, co-regulated by Cbl-CIN85 and Endophilin A1 PMID: 21829671
    18. Alterations of SH3GL2 and CDKN2A loci have a synergistic role in the development of early-onset breast cancer. PMID: 18239974

    顯示更多

    收起更多

  • 亞細(xì)胞定位:
    Cytoplasm. Membrane; Peripheral membrane protein. Early endosome. Cell junction, synapse, presynapse.
  • 蛋白家族:
    Endophilin family
  • 組織特異性:
    Brain, mostly in frontal cortex. Expressed at high level in fetal cerebellum.
  • 數(shù)據(jù)庫鏈接:

    HGNC: 10831

    OMIM: 604465

    KEGG: hsa:6456

    STRING: 9606.ENSP00000369981

    UniGene: Hs.743740



主站蜘蛛池模板: 国产果冻豆传媒麻婆| 四川老熟女下面又黑又肥| 欧美亚洲日本国产综合在线| 国产精品青青青高清在线| 成人无遮挡18禁免费视频| 国产免码va在线观看免费| 男男啪啪激烈高潮cc漫画免费| 欧美高清精品一区二区| 巨熟乳波霸若妻在线播放| 亚洲人成未满十八禁网站| 久久国语露脸国产精品电影| 国产乱子伦视频在线播放| 久久久精品456亚洲影院| 又大又紧又粉嫩18p少妇 | 国精产品一二三区传媒公司| 人牛交vide欧美xxxx| 国产精品国产三级国av在线观看| 农村老熟妇乱子伦视频| 精品国产av色一区二区深夜久久| 97碰碰碰免费公开在线视频 | 国内精品视频自在一区| 欧美黑人性暴力猛交喷水| 亚洲性猛交xxxx| 久久久久欧美精品| 中文日产乱幕九区无线码| 国农村精品国产自线拍| 亚洲日韩成人无码| 亚洲精品无码久久千人斩| 美女被啪到深处抽搐视频| 好大好硬好爽免费视频| 亚洲人成在线观看| 无码人妻精品丰满熟妇区| 精品无码久久久久国产app| 人妻丰满熟妇av无码区免| 暖暖 免费 高清 日本 在线| 偷自拍亚洲视频在线观看99| 97人妻天天摸天天爽天天| 人人爽人人澡人人高潮| 777yyy亚洲精品久久久| 伊人久久大香线蕉亚洲五月天| 亚洲国产成人久久一区二区三区|