在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. SEPT2 Antibody

SEPT2 Antibody

  • 中文名稱：
    SEPT2兔多克隆抗體
  • 貨號：
    CSB-PA021025GA01HU
  • 規(guī)格：
    ￥3,900
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
    SEPT2
  • 別名：
    SEPTIN2 antibody; DIFF6 antibody; KIAA0158 antibody; NEDD5 antibody; SEPT2 antibody; Septin-2 antibody; Neural precursor cell expressed developmentally down-regulated protein 5 antibody; NEDD-5 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human,Mouse,Rat
  • 免疫原：
    Human SEPT2
  • 免疫原種屬：
    Homo sapiens (Human)
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity Purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產(chǎn)品提供形式：
    Liquid
  • 應用范圍：
    ELISA,WB,IHC,IF
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    Filament-forming cytoskeletal GTPase. Forms a filamentous structure with SEPTIN12, SEPTIN6, SEPTIN2 and probably SEPTIN4 at the sperm annulus which is required for the structural integrity and motility of the sperm tail during postmeiotic differentiation. Required for normal organization of the actin cytoskeleton. Plays a role in the biogenesis of polarized columnar-shaped epithelium by maintaining polyglutamylated microtubules, thus facilitating efficient vesicle transport, and by impeding MAP4 binding to tubulin. Required for the progression through mitosis. Forms a scaffold at the midplane of the mitotic splindle required to maintain CENPE localization at kinetochores and consequently chromosome congression. During anaphase, may be required for chromosome segregation and spindle elongation. Plays a role in ciliogenesis and collective cell movements. In cilia, required for the integrity of the diffusion barrier at the base of the primary cilium that prevents diffusion of transmembrane proteins between the cilia and plasma membranes: probably acts by regulating the assembly of the tectonic-like complex (also named B9 complex) by localizing TMEM231 protein. May play a role in the internalization of 2 intracellular microbial pathogens, Listeria monocytogenes and Shigella flexneri.
  • 基因功能參考文獻：
    1. Results demonstrate that in stored platelets, septine-2 and septin-6 mRNAs have miR- 223 target sites, septin-2 and septin-6 are in complex with Ago-2. The results demonstrate that like in nucleated cells, enucleated platelets also have microRNA-based mechanisms for the regulation of their septins. PMID: 29943706
    2. Study discloses both SEPT2 and SEPT7 are essential for breast cancer cell migration and invasion by controlling MEK/ERK MAPKs activation. PMID: 27557506
    3. Depletion of septin 2 reduces Drp1 recruitment to mitochondria and results in hyperfused mitochondria and delayed FCCP-induced fission. PMID: 27215606
    4. septins protect ErbB2 from ubiquitylation, endocytosis and lysosomal degradation. Septin oligomerization regulates persistent expression of ErbB2/HER2 in gastric cancer cells. PMID: 27048593
    5. The results showed that SEPT2 has an oncogenic function through accelerated cell proliferation and invasion in biliary tract cancers, and is negatively regulated by miR-140-5p. PMID: 27155525
    6. From the nucleotide-free structure some interesting conclusions about the nucleotide binding properties of Cdc11 can be drawn; especially when aligning the structure with the structure of GDP bound Sept2 PMID: 26780475
    7. These results suggest that SEPTIN2-mediated cytoskeletal rearrangement and STATHMIN-mediated differentiation may contribute to changes in cell morphology and differentiation of H/RS cells with CD99 upregulation in Hodgkin lymphoma. PMID: 26000982
    8. Data indicate that forchlorfenuron (FCF) exhibits differential binding preference for septins SEPT2 and SEPT3. PMID: 24787956
    9. Authors report here that the septins SEPT2, -9, -11, and probably -7 form fibrillar structures around the chlamydial inclusion. PMID: 25293760
    10. Suggest PPAR-gamma activation down-regulates hepatocellular carcinoma cell SEPT2 levels to prevent tumor growth. PMID: 25592041
    11. SEPT2 forms a 1:1:1 complex with SEPT7 and SEPT9. PMID: 23572511
    12. The results shown in study support the hypothesis that single Septin 2, when present in excess or with unbalanced stoichiometries, may be unstable and assemble into amyloid-like structures. PMID: 21967827
    13. Data illustrated roles of SEPT9 that might contribute to hetero-trimeric septin complex formation. SEPT9 can substitute for septins of the SEPT2 group and partially for SEPT7. PMID: 21767235
    14. The SEPT2 provides the directional guidance cues necessary for polarizing the epithelial microtubule network. PMID: 21788367
    15. septin-2 plays a fundamental role in regulating barrier function by altering cortical actin expression. PMID: 20870893
    16. the role of SEPT2 and SEPT11 in the InlB-Met interactions PMID: 21504731
    17. Data show that Septins of the SEPT6 group preferentially interacted with septins of the SEPT2 group, SEPT3 group and SEPT7 group. PMID: 21082023
    18. Nedd5 is involved in the process of cytokinesis in human brain tumours. PMID: 12125979
    19. septins may form a mitotic scaffold for CENP-E and other effectors to coordinate cytokinesis with chromosome congression and segregation PMID: 15774761
    20. Nedd5 C-terminal is a novel autoantigen in systemic lupus erythematosus (SLE) patients and may be a valuable tool for diagnosing neuropsychiatric SLE. PMID: 15987492
    21. protein encoded by SEPT2 is highly homologous to septins 1, 4 and 5 and is involved in the coordination of several key steps of mitosis PMID: 16682951
    22. septin 2, 6, and 7 complexes make up polymerized filaments PMID: 16914550
    23. crystal structures of the human SEPT2 G domain and the heterotrimeric human SEPT2-SEPT6-SEPT7 complex PMID: 17637674
    24. Study shows that in epithelial cells septin 2 fibers colocalize with a subset of microtubule tracks composed of polyglutamylated tubulin. PMID: 18209106
    25. A novel MLL-SEPT2 fusion variant in therapy-related myelodysplastic syndrome is reported. PMID: 18656699
    26. confirmed that the phosphorylation of SEPT2 on Ser218 by CK2 was crucial to the proliferation of HCC. These results suggest that SEPT2 might be a promising target for liver cancer therapy PMID: 19165576
    27. SEPT2 is essential for the InlB-mediated entry of Listeria, but SEPT11 is not, which distinguishes the roles of different mammalian septins PMID: 19234302

    顯示更多

    收起更多

  • 亞細胞定位：
    Cytoplasm. Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, spindle. Chromosome, centromere, kinetochore. Cleavage furrow. Midbody. Cytoplasm, cell cortex. Cell projection, cilium membrane. Cell projection, cilium, flagellum.
  • 蛋白家族：
    TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily, Septin GTPase family
  • 組織特異性：
    Widely expressed. Up-regulated in liver cancer.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 7729

    OMIM: 601506

    KEGG: hsa:4735

    STRING: 9606.ENSP00000353157

    UniGene: Hs.721234



主站蜘蛛池模板： 永久免费观看黄网视频| 97在线视频人妻无码| 国产精品成人a区在线观看| 亚洲制服 视频在线观看| 在线亚洲专区高清中文字幕| 免费看欧美成人a片无码| 国产成人精品无码播放| 天天爽夜夜爽夜夜爽精品视频 | 亚洲成在人线视av| 狠狠躁夜夜躁人人爽天天| 久久99日韩国产精品久久99| 乱精品一区字幕二区| 久久精品黄aa片一区二区三区| 蜜臀av99无码精品国产专区| 撕开奶罩揉吃奶高潮av在线观看 | 任你躁x7x7x7x7在线观看| 欧美极品少妇性运交| 国产八十老太另类| 国产在线精品一区二区三区| 国产99久久久国产精品～～牛| 国产性猛交╳xxx乱大交| a v 在线视频 亚洲免费| 爱情岛论坛网亚洲品质| 播放男人添女人下边视频| 亚洲精品久久久久久成人| 成熟老妇女毛茸茸的做性 | 亚洲日韩中文字幕在线不卡最新 | 奇米影视第四色首页| 久久久久久亚洲精品成人| 在教室伦流澡到高潮h麻豆| 无码成人精品区在线观看| 成a人片亚洲日本久久| 伊人蕉影院久亚洲高清| 在线精品自偷自拍无码| 黄a无码片内射无码视频| 国产高清午夜人成在线观看 | 国产最新进精品视频| 亚洲精品成人老司机影视| 日韩不卡1卡2卡三卡网站| 亚洲乱码中文字幕综合| 2020精品自拍视频曝光|