在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. SENP6 Antibody

SENP6 Antibody

  • 中文名稱：
    SENP6兔多克隆抗體
  • 貨號：
    CSB-PA563802
  • 規格：
    ￥1100
  • 圖片：
    • Gel: 6%SDS-PAGE,Lysate: 40 μg,,Primary antibody: CSB-PA563802(SENP6 Antibody) at dilution 1/450 dilution,Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution,Exposure time: 8 minutes
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
    SENP6
  • 別名：
    2810017C20Rik antibody; FLJ11355 antibody; FLJ11887 antibody; KIAA0389 antibody; KIAA0797 antibody; SENP 6 antibody; Senp6 antibody; SENP6_HUMAN antibody; Sentrin specific protease 6 antibody; Sentrin-specific protease 6 antibody; Sentrin/SUMO specific protease SENP6 antibody; Sentrin/SUMO-specific protease SENP6 antibody; SSP 1 antibody; SSP1 antibody; SUMO 1 specific protease 1 antibody; SUMO 1 specific protease antibody; SUMO-1-specific protease 1 antibody; SUMO1 specific protease 1 antibody; SUMO1 specific protease antibody; SUMO1/sentrin specific peptidase 6 antibody; SUSP 1 antibody; SUSP1 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human,Mouse
  • 免疫原：
    Synthetic peptide of Human SENP6
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen affinity purification
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA,WB
  • 推薦稀釋比：
    Application Recommended Dilution
    ELISA 1:1000-1:2000
    WB 1:200-1:1000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Protease that deconjugates SUMO1, SUMO2 and SUMO3 from targeted proteins. Processes preferentially poly-SUMO2 and poly-SUMO3 chains, but does not efficiently process SUMO1, SUMO2 and SUMO3 precursors. Deconjugates SUMO1 from RXRA, leading to transcriptional activation. Involved in chromosome alignment and spindle assembly, by regulating the kinetochore CENPH-CENPI-CENPK complex. Desumoylates PML and CENPI, protecting them from degradation by the ubiquitin ligase RNF4, which targets polysumoylated proteins for proteasomal degradation. Desumoylates also RPA1, thus preventing recruitment of RAD51 to the DNA damage foci to initiate DNA repair through homologous recombination.
  • 基因功能參考文獻：
    1. LANA could bind to the promoter region of the SENP6 gene and inhibit SENP6 expression while the regulated SENP6 could in turn modulate the abundance of LANA through desumoylation. PMID: 28615201
    2. the structure of SENP2-Loop1 in complex with SUMO2 was solved at 2.15 A resolution, and reveals the details of an interface exclusive to SENP6/7 and the formation of unique contacts between both proteins PMID: 24424631
    3. Loop 1 insertion in SENP6 and SENP7 as a platform to discriminate between SUMO1 and SUMO2/3 isoforms in this subclass of the SUMO protease family. PMID: 21878624
    4. study of substrate specificity of SENP6; it is also capable of cleaving mixed chains of SUMO-1 and SUMO-2/3; mutation of catalytic cysteine of results in its accumulation in PML NBs; findings indicate SUMO-modified PML is a substrate of SENP6 PMID: 21148299
    5. Results reveal a novel mechanism whereby the finely balanced activities of SENP6 and RNF4 control vertebrate kinetochore assembly through SUMO-targeted destabilization of inner plate components. PMID: 20212317
    6. SENP1 localization is influenced by expression and localization of SUMO-1-conjugated target proteins within the cell. PMID: 14563852
    7. SUSP1 plays an important role in the control of the transcriptional activity of RXRalpha and thus in the RXRalpha-mediated cellular processes PMID: 16912044
    8. We have investigated the specificity of SUSP1 using vinyl sulfone inhibitors and model substrates. SUSP1 has a strong paralogue bias toward SUMO2/3 and acts preferentially on substrates containing three or more SUMO2/3 moieties PMID: 17000875
    9. SENP6 and SENP7 exhibit lower rates for processing pre-SUMO1, pre-SUMO2, or pre-SUMO3 in comparison with SENP2 PMID: 18799455

    顯示更多

    收起更多

  • 亞細胞定位：
    Nucleus.
  • 蛋白家族：
    Peptidase C48 family
  • 組織特異性：
    Highly expressed in reproductive organs, such as testis, ovary and prostate.
  • 數據庫鏈接：

    HGNC: 20944

    OMIM: 605003

    KEGG: hsa:26054

    STRING: 9606.ENSP00000402527

    UniGene: Hs.485784



主站蜘蛛池模板： 无码日韩精品一区二区人妻| 欧美国产综合欧美视频| 曰本女人与公拘交酡免费视频| 四虎影视在线影院在线观看| 乱人伦中文视频在线| 亚洲性视频免费视频网站| 国产精品久久香蕉免费播放| a毛片免费全部播放| 欧美综合在线激情专区| 国产香蕉尹人视频在线| 欧美性生 活18~19| 中文无码精品a∨在线观看不卡 | 国产乱色精品成人免费视频| 日韩国产丝袜人妻一二区| 成在人线av无码免费高潮水老板| 美女mm131午夜福利在线| 亚洲第一无码av无码专区| 亚洲一区二区三区尿失禁| 娇妻玩4p被三个男人伺候电影| 中文字日产幕乱五区| 在线观看国产日韩亚洲中 | 亚洲精品国产精品国产自2022| 无码被窝影院午夜看片爽爽jk| 在线 | 国产精品星空传媒丿| 久久久精品日本一区二区三区 | av免费网站在线观看| 亚洲 自拍 另类 欧美 综合| 久艹视频免费看| 尤物tv国产精品看片在线| 天堂…中文在线最新版在线 | 鲁一鲁一鲁一鲁一澡| 国产素人在线观看人成视频| 亚洲男人的天堂在线va| 亚洲成av人片在线播放无码| 精品国产一区二区三区av 性色| 欧美zozo另类特级| 亚洲爆乳成av人在线蜜芽| 国产精品无码嫩草地址更新| 亚洲精品乱码久久久久久日本| 无码人妻aⅴ一区二区三区玉蒲团| 欧美丰满熟妇xxxx性ppx人|