在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. SENP6 Antibody

SENP6 Antibody

  • 中文名稱：
    SENP6兔多克隆抗體
  • 貨號：
    CSB-PA250761
  • 規(guī)格：
    ￥1100
  • 圖片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human breast cancer tissue using CSB-PA250761(SENP6 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: ×200)
    • Gel: 6%SDS-PAGE,Lysate: 40 μg,Lane 1-2: Hela cells, K562 cells,Primary antibody: CSB-PA250761(SENP6 Antibody) at dilution 1/450 dilution,Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution,Exposure time: 5 minutes
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
    SENP6
  • 別名：
    2810017C20Rik antibody; FLJ11355 antibody; FLJ11887 antibody; KIAA0389 antibody; KIAA0797 antibody; SENP 6 antibody; Senp6 antibody; SENP6_HUMAN antibody; Sentrin specific protease 6 antibody; Sentrin-specific protease 6 antibody; Sentrin/SUMO specific protease SENP6 antibody; Sentrin/SUMO-specific protease SENP6 antibody; SSP 1 antibody; SSP1 antibody; SUMO 1 specific protease 1 antibody; SUMO 1 specific protease antibody; SUMO-1-specific protease 1 antibody; SUMO1 specific protease 1 antibody; SUMO1 specific protease antibody; SUMO1/sentrin specific peptidase 6 antibody; SUSP 1 antibody; SUSP1 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Synthetic peptide of Human SENP6
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen affinity purification
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA,WB,IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    ELISA 1:1000-1:2000
    WB 1:200-1:1000
    IHC 1:25-1:100
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    Protease that deconjugates SUMO1, SUMO2 and SUMO3 from targeted proteins. Processes preferentially poly-SUMO2 and poly-SUMO3 chains, but does not efficiently process SUMO1, SUMO2 and SUMO3 precursors. Deconjugates SUMO1 from RXRA, leading to transcriptional activation. Involved in chromosome alignment and spindle assembly, by regulating the kinetochore CENPH-CENPI-CENPK complex. Desumoylates PML and CENPI, protecting them from degradation by the ubiquitin ligase RNF4, which targets polysumoylated proteins for proteasomal degradation. Desumoylates also RPA1, thus preventing recruitment of RAD51 to the DNA damage foci to initiate DNA repair through homologous recombination.
  • 基因功能參考文獻：
    1. LANA could bind to the promoter region of the SENP6 gene and inhibit SENP6 expression while the regulated SENP6 could in turn modulate the abundance of LANA through desumoylation. PMID: 28615201
    2. the structure of SENP2-Loop1 in complex with SUMO2 was solved at 2.15 A resolution, and reveals the details of an interface exclusive to SENP6/7 and the formation of unique contacts between both proteins PMID: 24424631
    3. Loop 1 insertion in SENP6 and SENP7 as a platform to discriminate between SUMO1 and SUMO2/3 isoforms in this subclass of the SUMO protease family. PMID: 21878624
    4. study of substrate specificity of SENP6; it is also capable of cleaving mixed chains of SUMO-1 and SUMO-2/3; mutation of catalytic cysteine of results in its accumulation in PML NBs; findings indicate SUMO-modified PML is a substrate of SENP6 PMID: 21148299
    5. Results reveal a novel mechanism whereby the finely balanced activities of SENP6 and RNF4 control vertebrate kinetochore assembly through SUMO-targeted destabilization of inner plate components. PMID: 20212317
    6. SENP1 localization is influenced by expression and localization of SUMO-1-conjugated target proteins within the cell. PMID: 14563852
    7. SUSP1 plays an important role in the control of the transcriptional activity of RXRalpha and thus in the RXRalpha-mediated cellular processes PMID: 16912044
    8. We have investigated the specificity of SUSP1 using vinyl sulfone inhibitors and model substrates. SUSP1 has a strong paralogue bias toward SUMO2/3 and acts preferentially on substrates containing three or more SUMO2/3 moieties PMID: 17000875
    9. SENP6 and SENP7 exhibit lower rates for processing pre-SUMO1, pre-SUMO2, or pre-SUMO3 in comparison with SENP2 PMID: 18799455

    顯示更多

    收起更多

  • 亞細胞定位：
    Nucleus.
  • 蛋白家族：
    Peptidase C48 family
  • 組織特異性：
    Highly expressed in reproductive organs, such as testis, ovary and prostate.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 20944

    OMIM: 605003

    KEGG: hsa:26054

    STRING: 9606.ENSP00000402527

    UniGene: Hs.485784



主站蜘蛛池模板： 精品人妻av一区二区三区| 成人黄网站高清免费视频| 亚洲图片综合图区20p| 国产欧美在线观看不卡| 婷婷四房色播| 国产精品最新免费视频| 国产成人午夜在线视频a站| 亚洲第一无码xxxxxx| 国产精品日本一区二区在线播放| 日韩精品人妻无码久久影院| 日本亚州视频在线八a| 少妇被躁爽到高潮无码人狍大战| 97se亚洲国产综合自在线观看| 天堂最新版资源网| 国产色情又大又粗又黄的电影| 欧美肥婆姓交大片| 一边摸一边做爽的视频17国产| 国产免费人成在线视频网站| 男女啪啪高潮无遮挡免费| 国产精品久久久久久久久久久久午夜片| 亚洲一区二区三区无码久久| 夜夜澡天天碰人人爱av| 国产无吗一区二区三区在线欢| 亚洲欧洲免费无码| 污污又黄又爽免费的网站| 国产av亚洲精品久久久久久小说 | 国产精品未满十八禁止观看| 新婚少妇无套内谢国语播放| 亚洲欧美日本中文字不卡| 成年无码a√片在线观看| 欧洲精品码一区二区三区| 青青草无码免费一二三区| 2021国产精品成人免费视频| 人妻少妇精品久久久久久| 欧美 日韩 亚洲 在线| 无码av中文一区二区三区| 天堂资源最新在线| 性一交一乱一伧国产女士spa| 强伦姧人妻免费无码电影| 久久久日韩精品一区二区三区| 末发育娇小性色xxxxx视频|