在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

SEMA7A Antibody

  • 中文名稱:
    SEMA7A兔多克隆抗體
  • 貨號:
    CSB-PA613575
  • 規格:
    ¥1090
  • 圖片:
    • Immunohistochemical analysis of paraffin-embedded human-brain, antibody was diluted at 1:200
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
  • 別名:
    CD 108 antibody; CD108 antibody; CD108 antigen antibody; CDw108 antibody; H Sema K1 antibody; H Sema L antibody; H-SEMA-K1 antibody; H-Sema-L antibody; JMH antibody; JMH blood group antigen antibody; John Milton Hagen blood group H Sema K1 antibody; John Milton Hargen human blood group Ag antibody; John-Milton-Hargen human blood group Ag antibody; MGC126692 antibody; MGC126696 antibody; SEM7A_HUMAN antibody; Sema domain immunoglobulin domain (Ig) and GPI membrane anchor 7A antibody; Sema K1 antibody; Sema L antibody; SEMA7A antibody; SEMAK1 antibody; SEMAL antibody; Semaphorin 7A GPI membrane anchor antibody; Semaphorin K1 antibody; Semaphorin L antibody; Semaphorin-7A antibody; Semaphorin-K1 antibody; Semaphorin-L antibody; Semaphorin7a antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Synthetic peptide from Human protein at AA range: 101-150
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 純化方式:
    The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    IHC,ELISA
  • 推薦稀釋比:
    Application Recommended Dilution
    IHC IHC-p:1:50-300
    ELISA 1:10000-20000
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Plays an important role in integrin-mediated signaling and functions both in regulating cell migration and immune responses. Promotes formation of focal adhesion complexes, activation of the protein kinase PTK2/FAK1 and subsequent phosphorylation of MAPK1 and MAPK3. Promotes production of proinflammatory cytokines by monocytes and macrophages. Plays an important role in modulating inflammation and T-cell-mediated immune responses. Promotes axon growth in the embryonic olfactory bulb. Promotes attachment, spreading and dendrite outgrowth in melanocytes.
  • 基因功能參考文獻:
    1. These findings indicate that Sema7A as a potent activator of T cells and monocytes in the immune response contributes to the inflammation and progression of rheumatoid arthritis PMID: 28109308
    2. short hairpin-mediated silencing of SEMA7A reveals roles for semaphorin 7a in the promotion of DCIS growth, motility and invasion as well as lymphangiogenesis in the tumor microenvironment. Our studies also uncover a relationship between COX-2 and semaphorin 7a expression and suggest that semaphorin 7a promotes tumor cell invasion on collagen and lymphangiogenesis via activation of b1-integrin receptor PMID: 27065336
    3. Our results identified FGL2, GAL, SEMA4D, SEMA7A, and IDO1 as new candidate genes that could be involved in MSCs-mediated immunomodulation. FGL2, GAL, SEMA4D, SEMA7A, and IDO1 genes appeared to be differentially transcribed in the different MSC populations. Moreover, these genes were not similarly modulated following MSCs-exposure to inflammatory signals PMID: 28336906
    4. Sema3A and sema7A expression correlated with the inflammatory activity of the multiple sclerosis (MS) lesions, suggesting their involvement in the immunological process that takes place in MS. PMID: 26432853
    5. SEMA7A has a role in the development of lung injury PMID: 26752048
    6. This study demonstrates that Sema7A controls the assembly of actin-based protrusions that drive Dendritic cell migration in response to CCL21. PMID: 26597008
    7. These results suggest that SEMA7a plays a role as a CSF biomarkers associated with the conversion to clinically definite multiple sclerosis in clinically isolated syndromes patients PMID: 25406498
    8. heterozygous missense variants in SEMA3A and SEMA7A may modify the phenotype of Kallmann syndrome but most likely are not alone sufficient to cause the disorder PMID: 24522099
    9. SEMA7A was expressed in the liver and was increased in the course of liver fibrosis, both in mice and in humans. PMID: 23850082
    10. Semaphorin 7A is a potentially important modulator of eosinophil profibrotic functions in the airway remodeling of patients with chronic asthma. PMID: 24333536
    11. two MTRAP monomers interact via their tandem TSR domains with the Sema domains of a Semaphorin-7A homodimer PMID: 23166499
    12. Semaphorin 7A protein variants differentially regulate T-cell activity. PMID: 22845496
    13. Sema7A markedly reduces the production rates of megakaryocytes and platelets from CD34(+) progenitor cells. PMID: 22448926
    14. We report here the expression and induction of semaphorin 7A (SEMA7A) on endothelium through hypoxia-inducible factor 1alpha during hypoxia. PMID: 22891341
    15. Sema7A on keratinocytes and beta1-integrin on monocytes contribute to monocyte activation by keratinocytes within skin inflammation, inducing IL-8 PMID: 21524887
    16. A new SEMA7A variant was identified in Native American plasma samples, and an alloantibody that recognizes the wild-type protein PMID: 20854351
    17. Study reports the structures of Sema7A and A39R complexed with the Semaphorin-binding module of PlexinC1; both structures show two PlexinC1 molecules symmetrically bridged by Semaphorin dimers. PMID: 20727575
    18. Sema7A is a potent stimulator of cytokine production, chemotaxis and superoxide release in monocytes PMID: 12193228
    19. SEMA 7A might be a molecule involved in the terminal innervation of the dentin-pulp complex. PMID: 15907379
    20. Polymorphisms in SEMA7A may play a role in decreased bone mineral density and increased risk of vertebral fracture. PMID: 16372136
    21. beta1-integrins and Plexin C1 receptors are ligands for Semaphorin 7a, and that signaling by these receptors has opposing effects on Semaphorin 7a-induced dendrite formation. PMID: 17671519
    22. Sema7A binds to human melanocytes through beta1-integrins and the Plexin C1 receptor PMID: 19318806

    顯示更多

    收起更多

  • 亞細胞定位:
    Cell membrane; Lipid-anchor, GPI-anchor; Extracellular side. Note=Detected in a punctate pattern on the cell membrane of basal and supra-basal skin keratinocytes.
  • 蛋白家族:
    Semaphorin family
  • 組織特異性:
    Detected in skin keratinocytes and on endothelial cells from skin blood vessels (at protein level). Expressed in fibroblasts, keratinocytes, melanocytes, placenta, testis, ovary, spleen, brain, spinal chord, lung, heart, adrenal gland, lymph nodes, thymus
  • 數據庫鏈接:

    HGNC: 10741

    OMIM: 607961

    KEGG: hsa:8482

    STRING: 9606.ENSP00000261918

    UniGene: Hs.24640



主站蜘蛛池模板: 无码视频一区二区三区在线观看| 国色天香成人一区二区| 羞国产在线拍揄自揄视频| 无码人妻精品一区二区蜜桃色欲| 国产成人小视频| 久久国产精品成人影院| 2021久久精品国产99国产精品 | 男人扒开女人双腿猛进免费视频| 中字幕一区二区三区乱码| 亚洲精品国产精品国自产| 日韩精品一卡2卡三卡4卡| 国产成人8x人在线视频软件| 国产精品人成视频免费国产 | 精品国产在天天在线观看| 熟女人妻水多爽中文字幕| 成人免费看黄网站yyy456 | 欧美亚洲国产一区二区三区| 欧美大肥婆大肥bbbbb| av无码av无码专区| 日韩精品 中文字幕 视频在线| 少妇与大狼拘作爱性a| 久久精品国产亚洲a片高清不卡| 四虎国产精品永久地址入口| 国产精品久久自在自线不| 国产女人好紧好爽| 亚洲欧美日韩综合久久久| 九色综合九色综合色鬼| 上海少妇高潮狂叫喷水了| 欧美另类videosbestsex日本| 欧美丰腴丰满大屁股熟妇| 无码人妻专区免费视频| 国产真人性做爰久久网站| 国产婷婷一区二区三区| 国产精品爽爽久久久久久无码| 欧美色欧美亚洲高清在线视频| 日日澡夜夜澡人人高潮| 国产福利萌白酱精品tv一区| 人妻无码中字在线a| 国产成人综合久久亚洲精品| 国产精品亚洲精品日韩已满十八小 | 色偷偷www.8888在线观看 |