在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

SEMA7A Antibody

  • 中文名稱:
    SEMA7A兔多克隆抗體
  • 貨號:
    CSB-PA613575
  • 規格:
    ¥1090
  • 圖片:
    • Immunohistochemical analysis of paraffin-embedded human-brain, antibody was diluted at 1:200
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
  • 別名:
    CD 108 antibody; CD108 antibody; CD108 antigen antibody; CDw108 antibody; H Sema K1 antibody; H Sema L antibody; H-SEMA-K1 antibody; H-Sema-L antibody; JMH antibody; JMH blood group antigen antibody; John Milton Hagen blood group H Sema K1 antibody; John Milton Hargen human blood group Ag antibody; John-Milton-Hargen human blood group Ag antibody; MGC126692 antibody; MGC126696 antibody; SEM7A_HUMAN antibody; Sema domain immunoglobulin domain (Ig) and GPI membrane anchor 7A antibody; Sema K1 antibody; Sema L antibody; SEMA7A antibody; SEMAK1 antibody; SEMAL antibody; Semaphorin 7A GPI membrane anchor antibody; Semaphorin K1 antibody; Semaphorin L antibody; Semaphorin-7A antibody; Semaphorin-K1 antibody; Semaphorin-L antibody; Semaphorin7a antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Synthetic peptide from Human protein at AA range: 101-150
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 純化方式:
    The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    IHC,ELISA
  • 推薦稀釋比:
    Application Recommended Dilution
    IHC IHC-p:1:50-300
    ELISA 1:10000-20000
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Plays an important role in integrin-mediated signaling and functions both in regulating cell migration and immune responses. Promotes formation of focal adhesion complexes, activation of the protein kinase PTK2/FAK1 and subsequent phosphorylation of MAPK1 and MAPK3. Promotes production of proinflammatory cytokines by monocytes and macrophages. Plays an important role in modulating inflammation and T-cell-mediated immune responses. Promotes axon growth in the embryonic olfactory bulb. Promotes attachment, spreading and dendrite outgrowth in melanocytes.
  • 基因功能參考文獻:
    1. These findings indicate that Sema7A as a potent activator of T cells and monocytes in the immune response contributes to the inflammation and progression of rheumatoid arthritis PMID: 28109308
    2. short hairpin-mediated silencing of SEMA7A reveals roles for semaphorin 7a in the promotion of DCIS growth, motility and invasion as well as lymphangiogenesis in the tumor microenvironment. Our studies also uncover a relationship between COX-2 and semaphorin 7a expression and suggest that semaphorin 7a promotes tumor cell invasion on collagen and lymphangiogenesis via activation of b1-integrin receptor PMID: 27065336
    3. Our results identified FGL2, GAL, SEMA4D, SEMA7A, and IDO1 as new candidate genes that could be involved in MSCs-mediated immunomodulation. FGL2, GAL, SEMA4D, SEMA7A, and IDO1 genes appeared to be differentially transcribed in the different MSC populations. Moreover, these genes were not similarly modulated following MSCs-exposure to inflammatory signals PMID: 28336906
    4. Sema3A and sema7A expression correlated with the inflammatory activity of the multiple sclerosis (MS) lesions, suggesting their involvement in the immunological process that takes place in MS. PMID: 26432853
    5. SEMA7A has a role in the development of lung injury PMID: 26752048
    6. This study demonstrates that Sema7A controls the assembly of actin-based protrusions that drive Dendritic cell migration in response to CCL21. PMID: 26597008
    7. These results suggest that SEMA7a plays a role as a CSF biomarkers associated with the conversion to clinically definite multiple sclerosis in clinically isolated syndromes patients PMID: 25406498
    8. heterozygous missense variants in SEMA3A and SEMA7A may modify the phenotype of Kallmann syndrome but most likely are not alone sufficient to cause the disorder PMID: 24522099
    9. SEMA7A was expressed in the liver and was increased in the course of liver fibrosis, both in mice and in humans. PMID: 23850082
    10. Semaphorin 7A is a potentially important modulator of eosinophil profibrotic functions in the airway remodeling of patients with chronic asthma. PMID: 24333536
    11. two MTRAP monomers interact via their tandem TSR domains with the Sema domains of a Semaphorin-7A homodimer PMID: 23166499
    12. Semaphorin 7A protein variants differentially regulate T-cell activity. PMID: 22845496
    13. Sema7A markedly reduces the production rates of megakaryocytes and platelets from CD34(+) progenitor cells. PMID: 22448926
    14. We report here the expression and induction of semaphorin 7A (SEMA7A) on endothelium through hypoxia-inducible factor 1alpha during hypoxia. PMID: 22891341
    15. Sema7A on keratinocytes and beta1-integrin on monocytes contribute to monocyte activation by keratinocytes within skin inflammation, inducing IL-8 PMID: 21524887
    16. A new SEMA7A variant was identified in Native American plasma samples, and an alloantibody that recognizes the wild-type protein PMID: 20854351
    17. Study reports the structures of Sema7A and A39R complexed with the Semaphorin-binding module of PlexinC1; both structures show two PlexinC1 molecules symmetrically bridged by Semaphorin dimers. PMID: 20727575
    18. Sema7A is a potent stimulator of cytokine production, chemotaxis and superoxide release in monocytes PMID: 12193228
    19. SEMA 7A might be a molecule involved in the terminal innervation of the dentin-pulp complex. PMID: 15907379
    20. Polymorphisms in SEMA7A may play a role in decreased bone mineral density and increased risk of vertebral fracture. PMID: 16372136
    21. beta1-integrins and Plexin C1 receptors are ligands for Semaphorin 7a, and that signaling by these receptors has opposing effects on Semaphorin 7a-induced dendrite formation. PMID: 17671519
    22. Sema7A binds to human melanocytes through beta1-integrins and the Plexin C1 receptor PMID: 19318806

    顯示更多

    收起更多

  • 亞細胞定位:
    Cell membrane; Lipid-anchor, GPI-anchor; Extracellular side. Note=Detected in a punctate pattern on the cell membrane of basal and supra-basal skin keratinocytes.
  • 蛋白家族:
    Semaphorin family
  • 組織特異性:
    Detected in skin keratinocytes and on endothelial cells from skin blood vessels (at protein level). Expressed in fibroblasts, keratinocytes, melanocytes, placenta, testis, ovary, spleen, brain, spinal chord, lung, heart, adrenal gland, lymph nodes, thymus
  • 數據庫鏈接:

    HGNC: 10741

    OMIM: 607961

    KEGG: hsa:8482

    STRING: 9606.ENSP00000261918

    UniGene: Hs.24640



主站蜘蛛池模板: 国产午夜手机精彩视频| 欧美成人精品午夜免费影视| 影音先锋啪啪av资源网站| 亚洲性猛交xxxx| 无码人妻啪啪一区二区| 久久精品成人免费观看三| 国产偷国产偷亚洲清高孕妇| 国产玉足榨精视频在线观看| 一本加勒比hezyo无码资源网| 国产色播av在线观看| 国内偷窥一区二区三区视频| 色吊丝中文字幕| 影音先锋男人av鲁色资源网| 一区二区国产精品精华液| 国内精品美女视频免费直播| 无码一卡二卡三卡四卡| 成熟妇人a片免费看网站| 天堂va蜜桃一区二区三区| av一区二区三区人妻少妇| 亚洲一区二区三区自拍天堂| 乱子伦视频在线看| 国产精品乱码人妻一区二区三区| 婷婷俺也去俺也去官网| 又紧又黄的免费视频网站| 无码人妻精一区二区三区| 呦男呦女视频精品八区| 国产成人精品视频国产| 一本色综合亚洲精品蜜桃冫| 和岳每晚弄的高潮嗷嗷叫视频| 在线播放免费人成毛片试看| 久久―日本道色综合久久| 曰批免费视频播放免费| 久久久久欧美精品| 亚洲欧美综合精品成人网| 丰满白嫩人妻中出无码| 日韩精品成人无码专区免费| 国产偷伦视频片免费视频| 蜜桃视频在线观看免费网址入口| 久久久久99精品成人片三人毛片| 亚洲深深色噜噜狠狠爱网站| 人妻无码vs中文字幕久久av爆|