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  4. Human Semaphorin-7A(SEMA7A) ELISA kit

Human Semaphorin-7A(SEMA7A) ELISA kit

  • 中文名稱：
    人臂板蛋白-7A(SEMA7A)酶聯免疫試劑盒
  • 貨號：
    CSB-EL021000HU
  • 規格：
    96T/48T
  • 價格：
    ￥3600/￥2500
  • 其他：

產品詳情

  • 產品描述：
    人臂板蛋白-7A(SEMA7A)酶聯免疫試劑盒（CSB-EL021000HU）為雙抗夾心法ELISA試劑盒，定量檢測血清、血漿、組織勻漿、細胞裂解物樣本中的SEMA7A含量。試劑盒檢測范圍為0.312 ng/mL-20 ng/mL，適用于神經科學、腫瘤生物學及免疫學等基礎研究領域，特別適合用于探究SEMA7A在神經退行性疾病、腫瘤侵襲轉移或免疫細胞信號傳導中的作用機制，為相關疾病的分子機制研究提供可靠的定量分析工具本品僅用于科研，不用于臨床診斷，產品具體參數及操作步驟詳見產品說明書。
  • 別名：
    CD 108 ELISA Kit; CD108 ELISA Kit; CD108 antigen ELISA Kit; CDw108 ELISA Kit; H Sema K1 ELISA Kit; H Sema L ELISA Kit; H-SEMA-K1 ELISA Kit; H-Sema-L ELISA Kit; JMH ELISA Kit; JMH blood group antigen ELISA Kit; John Milton Hagen blood group H Sema K1 ELISA Kit; John Milton Hargen human blood group Ag ELISA Kit; John-Milton-Hargen human blood group Ag ELISA Kit; MGC126692 ELISA Kit; MGC126696 ELISA Kit; SEM7A_HUMAN ELISA Kit; Sema domain immunoglobulin domain (Ig) and GPI membrane anchor 7A ELISA Kit; Sema K1 ELISA Kit; Sema L ELISA Kit; SEMA7A ELISA Kit; SEMAK1 ELISA Kit; SEMAL ELISA Kit; Semaphorin 7A GPI membrane anchor ELISA Kit; Semaphorin K1 ELISA Kit; Semaphorin L ELISA Kit; Semaphorin-7A ELISA Kit; Semaphorin-K1 ELISA Kit; Semaphorin-L ELISA Kit; Semaphorin7a ELISA Kit
  • 縮寫：
  • Uniprot No.：
  • 種屬：
    Homo sapiens (Human)
  • 樣本類型：
    serum, plasma, tissue homogenates, cell lysates
  • 檢測范圍：
    0.312 ng/mL-20 ng/mL
  • 靈敏度：
    0.078 ng/mL
  • 反應時間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測波長：
    450 nm
  • 研究領域：
    Neuroscience
  • 測定原理：
    quantitative
  • 測定方法：
    Sandwich
  • 精密度：
    Intra-assay Precision (Precision within an assay): CV%<8%
    Three samples of known concentration were tested twenty times on one plate to assess.
    Inter-assay Precision (Precision between assays): CV%<10%
    Three samples of known concentration were tested in twenty assays to assess.
  • 線性度：
    To assess the linearity of the assay, samples were spiked with high concentrations of human SEMA7A in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.
    SampleSerum(n=4)
    1:1Average %93
    Range %87-97
    1:2Average %92
    Range %82-96
    1:4Average %94
    Range %84-98
    1:8Average %87
    Range %82-92
  • 回收率：
    The recovery of human SEMA7A spiked to levels throughout the range of the assay in various matrices was evaluated. Samples were diluted prior to assay as directed in the Sample Preparation section.
    Sample TypeAverage % RecoveryRange
    Serum (n=5) 8983-94
    EDTA plasma (n=4)10398-107
  • 標準曲線：
    These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.
    ng/mlOD1OD2AverageCorrected
    202.246 2.089 2.168 1.984
    101.596 1.692 1.644 1.460
    51.123 1.068 1.096 0.912
    2.50.699 0.687 0.693 0.509
    1.250.465 0.454 0.460 0.276
    0.6250.339 0.324 0.332 0.148
    0.3120.260 0.268 0.264 0.080
    00.185 0.183 0.184
  • 數據處理：
  • 貨期：
    3-5 working days

產品評價

靶點詳情

  • 功能：
    Plays an important role in integrin-mediated signaling and functions both in regulating cell migration and immune responses. Promotes formation of focal adhesion complexes, activation of the protein kinase PTK2/FAK1 and subsequent phosphorylation of MAPK1 and MAPK3. Promotes production of proinflammatory cytokines by monocytes and macrophages. Plays an important role in modulating inflammation and T-cell-mediated immune responses. Promotes axon growth in the embryonic olfactory bulb. Promotes attachment, spreading and dendrite outgrowth in melanocytes.
  • 基因功能參考文獻：
    1. These findings indicate that Sema7A as a potent activator of T cells and monocytes in the immune response contributes to the inflammation and progression of rheumatoid arthritis PMID: 28109308
    2. short hairpin-mediated silencing of SEMA7A reveals roles for semaphorin 7a in the promotion of DCIS growth, motility and invasion as well as lymphangiogenesis in the tumor microenvironment. Our studies also uncover a relationship between COX-2 and semaphorin 7a expression and suggest that semaphorin 7a promotes tumor cell invasion on collagen and lymphangiogenesis via activation of b1-integrin receptor PMID: 27065336
    3. Our results identified FGL2, GAL, SEMA4D, SEMA7A, and IDO1 as new candidate genes that could be involved in MSCs-mediated immunomodulation. FGL2, GAL, SEMA4D, SEMA7A, and IDO1 genes appeared to be differentially transcribed in the different MSC populations. Moreover, these genes were not similarly modulated following MSCs-exposure to inflammatory signals PMID: 28336906
    4. Sema3A and sema7A expression correlated with the inflammatory activity of the multiple sclerosis (MS) lesions, suggesting their involvement in the immunological process that takes place in MS. PMID: 26432853
    5. SEMA7A has a role in the development of lung injury PMID: 26752048
    6. This study demonstrates that Sema7A controls the assembly of actin-based protrusions that drive Dendritic cell migration in response to CCL21. PMID: 26597008
    7. These results suggest that SEMA7a plays a role as a CSF biomarkers associated with the conversion to clinically definite multiple sclerosis in clinically isolated syndromes patients PMID: 25406498
    8. heterozygous missense variants in SEMA3A and SEMA7A may modify the phenotype of Kallmann syndrome but most likely are not alone sufficient to cause the disorder PMID: 24522099
    9. SEMA7A was expressed in the liver and was increased in the course of liver fibrosis, both in mice and in humans. PMID: 23850082
    10. Semaphorin 7A is a potentially important modulator of eosinophil profibrotic functions in the airway remodeling of patients with chronic asthma. PMID: 24333536
    11. two MTRAP monomers interact via their tandem TSR domains with the Sema domains of a Semaphorin-7A homodimer PMID: 23166499
    12. Semaphorin 7A protein variants differentially regulate T-cell activity. PMID: 22845496
    13. Sema7A markedly reduces the production rates of megakaryocytes and platelets from CD34(+) progenitor cells. PMID: 22448926
    14. We report here the expression and induction of semaphorin 7A (SEMA7A) on endothelium through hypoxia-inducible factor 1alpha during hypoxia. PMID: 22891341
    15. Sema7A on keratinocytes and beta1-integrin on monocytes contribute to monocyte activation by keratinocytes within skin inflammation, inducing IL-8 PMID: 21524887
    16. A new SEMA7A variant was identified in Native American plasma samples, and an alloantibody that recognizes the wild-type protein PMID: 20854351
    17. Study reports the structures of Sema7A and A39R complexed with the Semaphorin-binding module of PlexinC1; both structures show two PlexinC1 molecules symmetrically bridged by Semaphorin dimers. PMID: 20727575
    18. Sema7A is a potent stimulator of cytokine production, chemotaxis and superoxide release in monocytes PMID: 12193228
    19. SEMA 7A might be a molecule involved in the terminal innervation of the dentin-pulp complex. PMID: 15907379
    20. Polymorphisms in SEMA7A may play a role in decreased bone mineral density and increased risk of vertebral fracture. PMID: 16372136
    21. beta1-integrins and Plexin C1 receptors are ligands for Semaphorin 7a, and that signaling by these receptors has opposing effects on Semaphorin 7a-induced dendrite formation. PMID: 17671519
    22. Sema7A binds to human melanocytes through beta1-integrins and the Plexin C1 receptor PMID: 19318806

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  • 亞細胞定位：
    Cell membrane; Lipid-anchor, GPI-anchor; Extracellular side. Note=Detected in a punctate pattern on the cell membrane of basal and supra-basal skin keratinocytes.
  • 蛋白家族：
    Semaphorin family
  • 組織特異性：
    Detected in skin keratinocytes and on endothelial cells from skin blood vessels (at protein level). Expressed in fibroblasts, keratinocytes, melanocytes, placenta, testis, ovary, spleen, brain, spinal chord, lung, heart, adrenal gland, lymph nodes, thymus
  • 數據庫鏈接：

    HGNC: 10741

    OMIM: 607961

    KEGG: hsa:8482

    STRING: 9606.ENSP00000261918

    UniGene: Hs.24640



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