在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. SEC61B Antibody

SEC61B Antibody

  • 中文名稱：
    SEC61B兔多克隆抗體
  • 貨號：
    CSB-PA020958GA01HU
  • 規格：
    ￥3,900
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
  • 別名：
    SEC61B; Protein transport protein Sec61 subunit beta
  • 宿主：
    Rabbit
  • 反應種屬：
    Human,Mouse
  • 免疫原：
    Human SEC61B
  • 免疫原種屬：
    Homo sapiens (Human)
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity Purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA,WB,IHC
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Component of SEC61 channel-forming translocon complex that mediates transport of signal peptide-containing precursor polypeptides across the endoplasmic reticulum (ER). Component of a ribosome-associated ER translocon complex involved in multi-pass membrane protein transport into the ER membrane and biogenesis. The SEC61 channel cooperates with the translocating protein TRAM1 to import nascent proteins into the ER. Required for PKD1/Polycystin-1 biogenesis.
  • 基因功能參考文獻：
    1. used whole exome sequencing in a discovery cohort of 102 unrelated patients who were excluded for mutations in the 2 most common polycystic liver disease genes, PRKCSH and SEC63, to identify heterozygous loss-of-function mutations in 3 additional genes, ALG8, GANAB, and SEC61B. Similarly to PRKCSH and SEC63, these genes encode proteins that are integral to the protein biogenesis pathway in the endoplasmic reticulum. PMID: 28375157
    2. Sec61beta overexpression increased tight junction modulation rates, in conjunction with enhanced delivery of claudin-4 from and to plasma membranes. PMID: 24882410
    3. Sec61beta-KD cells also exhibited altered ATP7A cellular distribution. PMID: 22710939
    4. SEC61beta and its autoantibody as biomarkers for colorectal cancer PMID: 21255561
    5. Sec61beta function provides an alternative pathway for nuclear transport that can be utilized by membrane-embedded proteins such as full-length EGFR. PMID: 20937808
    6. This indicates that EGF receptors are trafficked from the endoplasmic reticulum to the nucleus by a novel pathway that involves the Sec61 translocon. PMID: 17215517

    顯示更多

    收起更多

  • 亞細胞定位：
    Endoplasmic reticulum membrane; Single-pass membrane protein.
  • 蛋白家族：
    SEC61-beta family
  • 數據庫鏈接：

    HGNC: 16993

    OMIM: 609214

    KEGG: hsa:10952

    STRING: 9606.ENSP00000223641

    UniGene: Hs.191887



主站蜘蛛池模板： av在线播放日韩亚洲欧| 在线|国产精品女主播阳台| 综合激情五月综合激情五月激情1| 精品一区二区三区在线视频| 成人无码一区二区三区| 国内老熟妇对白xxxxhd| 美女视频黄是免费| 性色a∨精品高清在线观看| 亚洲精品无码久久毛片波多野吉衣| 无码中文av波多野结衣一区| 2022国产成人精品视频人| 亚洲欧美一区二区三区在线| 亚洲熟少妇在线播放999| 欧美性大战xxxxx久久久√| 国产网红无码精品视频| 日本理伦片午夜理伦片| 五月激激激综合网亚洲| 亚洲欧美不卡高清在线| 男女猛烈xx00免费视频试看| 西西人体大胆4444www| 成人a大片在线观看| 亚洲精品乱码久久久久久自慰| 亚洲啪av永久无码精品放毛片| 日本丰满熟妇videossex| 波多野无码黑人在线播放| 国产日韩在线视看第一页| 人妻熟女一区二区aⅴ向井蓝| 玩弄少妇的肉体k8经典| 精品一区国产vr| 真人作爱免费视频| 久久熟妇人妻午夜寂寞影院| 人人妻人人澡人人爽偷拍台湾| 亚洲精品成a人在线观看| 日本强伦姧人妻一区二区| 成人性欧美丨区二区三区| 免费看一区二区三区四区| 国产情侣真实露脸在线| 久久久www成人免费看片| 国产日产精品一区二区三区四区的特点| 欧美激情第1页| 亚洲精品久久久久久久久久吃药|