在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

SEC23A Antibody, FITC conjugated

  • 中文名稱:
    SEC23A兔多克隆抗體, FITC偶聯(lián)
  • 貨號(hào):
    CSB-PA618985LC01HU
  • 規(guī)格:
    ¥880
  • 其他:

產(chǎn)品詳情

  • 產(chǎn)品名稱:
    Rabbit anti-Homo sapiens (Human) SEC23A Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 別名:
    CLSD antibody; Protein transport protein Sec23A antibody; SC23A_HUMAN antibody; Sec23 homolog A (S. cerevisiae) antibody; SEC23-related protein A antibody; sec23a antibody
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human
  • 免疫原:
    Recombinant Human Protein transport protein Sec23A protein (424-569AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標(biāo)記方式:
    FITC
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式:
    Liquid
  • 儲(chǔ)存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能:
    Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules for their transport to the Golgi complex. Required for the translocation of insulin-induced glucose transporter SLC2A4/GLUT4 to the cell membrane.
  • 基因功能參考文獻(xiàn):
    1. This larger GWAS yields two loci harboring genome-wide significant variants affecting serum 25-hydroxyvitamin D levels (P = 4.7x10(-9) at rs8018720 in SEC23A, and P = 1.9x10(-14) at rs10745742 in AMDHD1). PMID: 29343764
    2. Mutation on serine207 of Sec23A protein changes Unc-51 like kinase 1(ULK 1) targeted phosphorylation. During elevated autophagy, induced by amino acid starvation, rapamycin, or overexpression of ULK1,phosphorylation of Sec23A reduced the interaction between vesicular transport proteins Sec23A and Sec31A. PMID: 28486929
    3. Data indicate that vesicular transport protein SEC23A as a target of miR-375. PMID: 27036030
    4. findings suggest that miR-21 promoted proliferation, migration, and invasion of colorectal cancer cells in vitro by down regulating the expression of Sec23A PMID: 27495250
    5. Hypomorphic mutations of SEC23B gene account for mild phenotypes of congenital dyserythropoietic anemia type II. PMID: 23453696
    6. show that membrane association of COPII components, and in particular of Sec23a, is impaired by ER stress-inducing agents suggesting the existence of a dynamic interplay between protein folding and COPII assembly at the ER PMID: 23994533
    7. Data indicate that a synthetic polypeptide containing the N terminus of bovine AE1 bound the Sec23A-Sec24C complex through a selective interaction with Sec24C. PMID: 23658022
    8. the BBF2H7-mediated Sec23A pathway is required for ER-to-Golgi procollagen trafficking to promote collagen synthesis PMID: 22495181
    9. Sec23A overexpression reduced cell growth but did not induce apoptosis, whereas inhibition of Sec23A stimulated cell proliferation PMID: 21593139
    10. When entering into mitosis, the COPII component Sec24Cp is simultaneously deglycosylated and phosphorylated; however, Sec23A is not. PMID: 15013749
    11. Sec23A mutation causes cranio-lenticulo-sutural dysplasia, and disrupts the nucleation of COPII coat proteins at endoplasmic reticulum exit sites. PMID: 17981133

    顯示更多

    收起更多

  • 相關(guān)疾病:
    Craniolenticulosutural dysplasia (CLSD)
  • 亞細(xì)胞定位:
    Cytoplasmic vesicle, COPII-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytosol.
  • 蛋白家族:
    SEC23/SEC24 family, SEC23 subfamily
  • 組織特異性:
    Ubiquitously expressed.
  • 數(shù)據(jù)庫鏈接:

    HGNC: 10701

    OMIM: 607812

    KEGG: hsa:10484

    STRING: 9606.ENSP00000306881

    UniGene: Hs.272927



主站蜘蛛池模板: 好爽太紧了舒服视频| 久久亚洲日韩精品一区二区三区| 久久精品成人免费国产片小草| 亚洲中文无码永久免| 成 人 网 站 免费观看| 国产又大又硬又粗| 久久久久久九九99精品| 2020久久香蕉国产线看观看| 女同性av片在线观看免费网站| 国产精品久久久久7777按摩| 久久亚洲精品人成综合网| 亚洲久久久久久中文字幕| 亚洲熟女一区二区三区| 波多野结衣aⅴ在线| 亚洲国产午夜精华无码福利| 成 人 a v免费视频在线观看| 国产精品自在在线午夜免费| 午夜精品久久久久久久99老熟妇| 日韩国产成人无码av毛片| 精品国产一区av天美传媒| 大肉大捧一进一出视频出来呀 | 精品国产欧美一区二区| 亚洲级αv无码毛片久久精品| 国产亚洲中文日本不卡二区| 日韩 高清 无码 人妻| 亚洲精品久久久口爆吞精| 吃奶呻吟打开双腿做受动态图| 日本欧美久久久久免费播放网| 最近中文字幕免费mv在线| 免费国产在线精品一区二区三区 | 午夜福利国产成人无码gif动图| 国产精品高潮呻吟av久久小说| 国内精品视频一区二区八戒| 国产免费又黄又爽又色毛| 国产乱人对白| 亚欧欧美人成视频在线| 国产传媒麻豆剧精品av| 国产精品一区二区久久不卡| 国产又色又爽又黄又免费软件 | 最近日本免费观看高清视频| 性久久久久久|