在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

SEC23A Antibody, FITC conjugated

  • 中文名稱:
    SEC23A兔多克隆抗體, FITC偶聯(lián)
  • 貨號(hào):
    CSB-PA618985LC01HU
  • 規(guī)格:
    ¥880
  • 其他:

產(chǎn)品詳情

  • 產(chǎn)品名稱:
    Rabbit anti-Homo sapiens (Human) SEC23A Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 別名:
    CLSD antibody; Protein transport protein Sec23A antibody; SC23A_HUMAN antibody; Sec23 homolog A (S. cerevisiae) antibody; SEC23-related protein A antibody; sec23a antibody
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human
  • 免疫原:
    Recombinant Human Protein transport protein Sec23A protein (424-569AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標(biāo)記方式:
    FITC
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式:
    Liquid
  • 儲(chǔ)存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能:
    Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules for their transport to the Golgi complex. Required for the translocation of insulin-induced glucose transporter SLC2A4/GLUT4 to the cell membrane.
  • 基因功能參考文獻(xiàn):
    1. This larger GWAS yields two loci harboring genome-wide significant variants affecting serum 25-hydroxyvitamin D levels (P = 4.7x10(-9) at rs8018720 in SEC23A, and P = 1.9x10(-14) at rs10745742 in AMDHD1). PMID: 29343764
    2. Mutation on serine207 of Sec23A protein changes Unc-51 like kinase 1(ULK 1) targeted phosphorylation. During elevated autophagy, induced by amino acid starvation, rapamycin, or overexpression of ULK1,phosphorylation of Sec23A reduced the interaction between vesicular transport proteins Sec23A and Sec31A. PMID: 28486929
    3. Data indicate that vesicular transport protein SEC23A as a target of miR-375. PMID: 27036030
    4. findings suggest that miR-21 promoted proliferation, migration, and invasion of colorectal cancer cells in vitro by down regulating the expression of Sec23A PMID: 27495250
    5. Hypomorphic mutations of SEC23B gene account for mild phenotypes of congenital dyserythropoietic anemia type II. PMID: 23453696
    6. show that membrane association of COPII components, and in particular of Sec23a, is impaired by ER stress-inducing agents suggesting the existence of a dynamic interplay between protein folding and COPII assembly at the ER PMID: 23994533
    7. Data indicate that a synthetic polypeptide containing the N terminus of bovine AE1 bound the Sec23A-Sec24C complex through a selective interaction with Sec24C. PMID: 23658022
    8. the BBF2H7-mediated Sec23A pathway is required for ER-to-Golgi procollagen trafficking to promote collagen synthesis PMID: 22495181
    9. Sec23A overexpression reduced cell growth but did not induce apoptosis, whereas inhibition of Sec23A stimulated cell proliferation PMID: 21593139
    10. When entering into mitosis, the COPII component Sec24Cp is simultaneously deglycosylated and phosphorylated; however, Sec23A is not. PMID: 15013749
    11. Sec23A mutation causes cranio-lenticulo-sutural dysplasia, and disrupts the nucleation of COPII coat proteins at endoplasmic reticulum exit sites. PMID: 17981133

    顯示更多

    收起更多

  • 相關(guān)疾病:
    Craniolenticulosutural dysplasia (CLSD)
  • 亞細(xì)胞定位:
    Cytoplasmic vesicle, COPII-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytosol.
  • 蛋白家族:
    SEC23/SEC24 family, SEC23 subfamily
  • 組織特異性:
    Ubiquitously expressed.
  • 數(shù)據(jù)庫鏈接:

    HGNC: 10701

    OMIM: 607812

    KEGG: hsa:10484

    STRING: 9606.ENSP00000306881

    UniGene: Hs.272927



主站蜘蛛池模板: 亚洲成av人片在线观看无| 亚洲国产精品av在线播放| 少妇与子乱在线观看| 免费乱理伦片在线观看八戒| 欧美熟妇性xxx交潮喷| 久久精品国产免费观看| 成人看片黄a免费看在线| 国产∨亚洲v天堂无码久久久| 亚洲aⅴ天堂av天堂无码| 少妇激情一区二区三区视频小说 | 狼友av永久网站免费观看孕交| a毛片免费全部播放| 影音先锋每日av色资源站| 人人澡超碰碰97碰碰碰| 日日摸天天碰中文字幕你懂的| 国产精品aⅴ在线观看| 国产成人国产在线观看| 国产农村熟妇videos| 国产无遮挡a片无码免费| 999久久久无码国产精品| 日本熟妇中文字幕三级| 无码人妻丰满熟妇啪啪网站 | 精品人妻少妇一区二区| 欧美巨大另类极品videosbest| 国产人妻高清国产拍精品| 无码人妻在线一区二区三区免费| 亚洲精品中文字幕无码蜜桃| 99久久精品免费看国产一区二区三区| 亚洲一区日韩高清中文字幕亚洲| 精品国产一区二区av麻豆| 成人性生交大片免费看视频app| 精品一卡二卡三卡| av激情亚洲男人的天堂| 国产又色又爽又刺激在线观看| 日本乱子人伦在线视频| 欧美乱强伦xxxxx高潮| 在线亚洲精品国产成人av剧情| 色狠狠av老熟女| 亚洲久久中文字幕www网站| 欧美特黄特色三级视频在线观看| 国产真实老熟女无套内射|