在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

SEC23A Antibody, Biotin conjugated

  • 中文名稱:
    SEC23A兔多克隆抗體, Biotin偶聯
  • 貨號:
    CSB-PA618985LD01HU
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) SEC23A Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 別名:
    CLSD antibody; Protein transport protein Sec23A antibody; SC23A_HUMAN antibody; Sec23 homolog A (S. cerevisiae) antibody; SEC23-related protein A antibody; sec23a antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Protein transport protein Sec23A protein (424-569AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Biotin
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules for their transport to the Golgi complex. Required for the translocation of insulin-induced glucose transporter SLC2A4/GLUT4 to the cell membrane.
  • 基因功能參考文獻:
    1. This larger GWAS yields two loci harboring genome-wide significant variants affecting serum 25-hydroxyvitamin D levels (P = 4.7x10(-9) at rs8018720 in SEC23A, and P = 1.9x10(-14) at rs10745742 in AMDHD1). PMID: 29343764
    2. Mutation on serine207 of Sec23A protein changes Unc-51 like kinase 1(ULK 1) targeted phosphorylation. During elevated autophagy, induced by amino acid starvation, rapamycin, or overexpression of ULK1,phosphorylation of Sec23A reduced the interaction between vesicular transport proteins Sec23A and Sec31A. PMID: 28486929
    3. Data indicate that vesicular transport protein SEC23A as a target of miR-375. PMID: 27036030
    4. findings suggest that miR-21 promoted proliferation, migration, and invasion of colorectal cancer cells in vitro by down regulating the expression of Sec23A PMID: 27495250
    5. Hypomorphic mutations of SEC23B gene account for mild phenotypes of congenital dyserythropoietic anemia type II. PMID: 23453696
    6. show that membrane association of COPII components, and in particular of Sec23a, is impaired by ER stress-inducing agents suggesting the existence of a dynamic interplay between protein folding and COPII assembly at the ER PMID: 23994533
    7. Data indicate that a synthetic polypeptide containing the N terminus of bovine AE1 bound the Sec23A-Sec24C complex through a selective interaction with Sec24C. PMID: 23658022
    8. the BBF2H7-mediated Sec23A pathway is required for ER-to-Golgi procollagen trafficking to promote collagen synthesis PMID: 22495181
    9. Sec23A overexpression reduced cell growth but did not induce apoptosis, whereas inhibition of Sec23A stimulated cell proliferation PMID: 21593139
    10. When entering into mitosis, the COPII component Sec24Cp is simultaneously deglycosylated and phosphorylated; however, Sec23A is not. PMID: 15013749
    11. Sec23A mutation causes cranio-lenticulo-sutural dysplasia, and disrupts the nucleation of COPII coat proteins at endoplasmic reticulum exit sites. PMID: 17981133

    顯示更多

    收起更多

  • 相關疾病:
    Craniolenticulosutural dysplasia (CLSD)
  • 亞細胞定位:
    Cytoplasmic vesicle, COPII-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytosol.
  • 蛋白家族:
    SEC23/SEC24 family, SEC23 subfamily
  • 組織特異性:
    Ubiquitously expressed.
  • 數據庫鏈接:

    HGNC: 10701

    OMIM: 607812

    KEGG: hsa:10484

    STRING: 9606.ENSP00000306881

    UniGene: Hs.272927



主站蜘蛛池模板: 午夜一区二区亚洲福利| 久久一本久综合久久爱| 55夜色66夜色国产精品视频| 一本色道久久东京热| 伊人久久大香线蕉无码不卡| 欧美影院成年免费版| 新婚少妇无套内谢国语播放| 国产a精彩视频精品视频下载| 国产丰满乱子伦无码专区| 乱无码伦视频在线观看| 日韩精品久久久久久免费| 亚洲欧美国产精品久久| 欧美gv在线观看| 免费人成视频网站在线观看18| 国产未成女一区二区| 最新国产在线拍揄自揄视频| 欧美一区二区三区久久综合| 亚洲国产专区校园欧美| 蜜桃视频在线观看免费网址入口| 亚洲视频一区| 国产精品福利自产拍在线观看| 久久www成人免费网站| 欧美丰满熟妇xxxx性ppx人| 亚洲综合色区中文字幕| 国产无套内射普通话对白| 亚洲国产成人久久综合人| 国产成人av在线影院无毒| 麻豆传传媒久久久爱| 快好爽射给我视频| 在线观看成人年视频免费| 国内精品自线一区二区三区2021| 精品香蕉99久久久久网站| 久久久久无码国产精品不卡| 无码av免费永久免费永久专区| 97久久国产成人免费网站| 精品综合久久久久久8888| 国语精品一区二区三区| 一出一进一爽一粗一大视频免费的| 亚洲日本乱码在线观看| 色欲香天天天综合网站| 熟妇人妻久久中文字幕|