在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. SCUBE2 Antibody, FITC conjugated

SCUBE2 Antibody, FITC conjugated

  • 中文名稱：
    SCUBE2兔多克隆抗體, FITC偶聯
  • 貨號：
    CSB-PA865101LC01HU
  • 規格：
    ￥880
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) SCUBE2 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    SCUBE2
  • 別名：
    4932442O19Rik antibody; Cegb1 antibody; Cegf1 antibody; CEGP1 antibody; Cegp1 protein antibody; CUB domain and EGF-like repeat containing 1 antibody; FLJ16792 antibody; FLJ35234 antibody; ICRFP703B1614Q5.1 antibody; MGC133057 antibody; Protein CEGP1 antibody; RGD1563998 antibody; SCUB2_HUMAN antibody; Scube2 antibody; Signal peptide; CUB and EGF-like domain-containing protein 2 antibody; Signal peptide; CUB domain; EGF-like 2 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Signal peptide, CUB and EGF-like domain-containing protein 2 protein (534-703AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    FITC
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式：
    Liquid
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Lipid-binding protein required for SHH long-range signaling by binding to the dually lipid-modified SHH (ShhNp) and by promoting ShhNp mobilization, solubilization and release from the cell membrane. Acts by enhancing the proteolytic processing (shedding) of the lipid-modified N- and C- terminal of ShhNp at the cell surface. Synergizes with DISP1 to increase SHH secretion. Probable cell surface coreceptor for VEGFR2 involved in VEGFR2-mediated angiogenesis.
  • 基因功能參考文獻：
    1. Overexpression of SCUBE2 inhibits non-small cell lung cancer cell proliferation and invasion through suppressing the Sonic hedgehog signaling pathway. PMID: 29883759
    2. Results confirm that heparan sulfate (HS) proteoglycans enrich Scube2 at the surface of Shh-producing cells and that Scube2-regulated proteolytic Shh processing and release depends on specific HS. PMID: 27199253
    3. Endothelial SCUBE2 may be a novel coreceptor for VEGFR2 and potentiate VEGF-induced signaling in adult angiogenesis. PMID: 27834687
    4. The Sonic hedgehog (Shh) signaling pathway was involved in the inhibitory effect of SCUBE2 overexpression on glioma cells. PMID: 27697090
    5. Overexpression of SCUBE2 is associated with Breast Cancer Recurrence. PMID: 27165221
    6. SCUBE2 expression was decreased at the transcriptional and translational levels in colorectal cancer tissues and significantly associated with clinical stage, the depth of tumor invasion, lymphnode metastasis, distant metastasis and histological grade. PMID: 25672935
    7. Sheddases and Scube2 act cooperatively to increase the pool of soluble bioactive Shh. PMID: 24522195
    8. Tumor suppressor SCUBE2 inhibits breast-cancer cell migration and invasion through the reversal of epithelial-mesenchymal transition. PMID: 24213532
    9. data suggest that signal peptide CUB domain (SCUBE2), like in breast cancer, associates with estrogen receptor alpha and might have a potential as prognostic or predictive marker in endometrial cancer PMID: 24053619
    10. Via obligate assistance of Scube1 and 3, Scube2 plays a center role to recruit dually lipid-modified Hedgehog transferred from Dispatched A (DispA), increasing Hh secretion by promoting its solubility. PMID: 24084593
    11. Domain and functional analysis of a novel breast tumor suppressor protein, SCUBE2. PMID: 21652720
    12. identification as secreted protein that is expressed in vascular endothelium and may play important roles in development, inflammation, and thrombosis PMID: 12270931
    13. Altered SCUBE2 expression is important in breast cancer progression and SCUBE2 may serve as a useful prognostic marker. PMID: 19369267
    14. The full-length cDNA of human SCUBE2 was isolated and the role in the hedgehog signalling cascade, was studied. PMID: 19480626

    顯示更多

    收起更多

  • 亞細胞定位：
    Secreted. Cell surface.
  • 組織特異性：
    Expressed in a broad spectrum of adult tissues.
  • 數據庫鏈接：

    HGNC: 30425

    OMIM: 611747

    KEGG: hsa:57758

    UniGene: Hs.523468



主站蜘蛛池模板： 动漫人妻h无码中文字幕| 久久精品中文字幕无码| 少妇内射视频播放舔大片| 日本国产网曝视频在线观看| 国产亚洲精品一区二三区| 中文字幕精品久久久久人妻| 日日橹狠狠爱欧美超碰| 麻豆蜜桃av蜜臀av色欲av| 国产成熟女人性满足视频| 国产亚洲产品影市在线产品| 老司机亚洲精品影院无码| 色欲天天婬色婬香综合网完整版| 熟妇激情内射com| 一区二区三区国产| 精品无码一区二区三区不卡| 十八禁啪啪无遮挡网站| 吃奶呻吟打开双腿做受视频| 日产精品一区二区| 亚洲精品国产第一区第二| 狠狠色狠狠色狠狠五月| 久久久国产精品| 国产肥熟女视频一区二区三区| 日韩欧美亚洲综合久久影院d3| 国产麻豆精品福利在线观看| 草色噜噜噜av在线观看香蕉| 久久亚洲精品国产亚洲老地址| 日本少妇无码精品12p| 被灌满精子的波多野结衣| 欧美孕妇变态重口另类| 新区乱码无人区二精东 | 玖玖玖国产精品视频| 久久亚洲日韩精品一区二区三区| 国产美女自慰在线观看| 中文字幕av高清片| 国产美女露脸口爆吞精| 少妇人妻丰满做爰xxx| 亚洲综合一区无码精品| 天堂√最新版中文在线天堂| 99热精国产这里只有精品| 国产精品自在线拍国产电影| 人妻熟女一区二区aⅴ图片|