在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. SCUBE2 Antibody, FITC conjugated

SCUBE2 Antibody, FITC conjugated

  • 中文名稱：
    SCUBE2兔多克隆抗體, FITC偶聯
  • 貨號：
    CSB-PA865101LC01HU
  • 規格：
    ￥880
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) SCUBE2 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    SCUBE2
  • 別名：
    4932442O19Rik antibody; Cegb1 antibody; Cegf1 antibody; CEGP1 antibody; Cegp1 protein antibody; CUB domain and EGF-like repeat containing 1 antibody; FLJ16792 antibody; FLJ35234 antibody; ICRFP703B1614Q5.1 antibody; MGC133057 antibody; Protein CEGP1 antibody; RGD1563998 antibody; SCUB2_HUMAN antibody; Scube2 antibody; Signal peptide; CUB and EGF-like domain-containing protein 2 antibody; Signal peptide; CUB domain; EGF-like 2 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Signal peptide, CUB and EGF-like domain-containing protein 2 protein (534-703AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    FITC
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式：
    Liquid
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Lipid-binding protein required for SHH long-range signaling by binding to the dually lipid-modified SHH (ShhNp) and by promoting ShhNp mobilization, solubilization and release from the cell membrane. Acts by enhancing the proteolytic processing (shedding) of the lipid-modified N- and C- terminal of ShhNp at the cell surface. Synergizes with DISP1 to increase SHH secretion. Probable cell surface coreceptor for VEGFR2 involved in VEGFR2-mediated angiogenesis.
  • 基因功能參考文獻：
    1. Overexpression of SCUBE2 inhibits non-small cell lung cancer cell proliferation and invasion through suppressing the Sonic hedgehog signaling pathway. PMID: 29883759
    2. Results confirm that heparan sulfate (HS) proteoglycans enrich Scube2 at the surface of Shh-producing cells and that Scube2-regulated proteolytic Shh processing and release depends on specific HS. PMID: 27199253
    3. Endothelial SCUBE2 may be a novel coreceptor for VEGFR2 and potentiate VEGF-induced signaling in adult angiogenesis. PMID: 27834687
    4. The Sonic hedgehog (Shh) signaling pathway was involved in the inhibitory effect of SCUBE2 overexpression on glioma cells. PMID: 27697090
    5. Overexpression of SCUBE2 is associated with Breast Cancer Recurrence. PMID: 27165221
    6. SCUBE2 expression was decreased at the transcriptional and translational levels in colorectal cancer tissues and significantly associated with clinical stage, the depth of tumor invasion, lymphnode metastasis, distant metastasis and histological grade. PMID: 25672935
    7. Sheddases and Scube2 act cooperatively to increase the pool of soluble bioactive Shh. PMID: 24522195
    8. Tumor suppressor SCUBE2 inhibits breast-cancer cell migration and invasion through the reversal of epithelial-mesenchymal transition. PMID: 24213532
    9. data suggest that signal peptide CUB domain (SCUBE2), like in breast cancer, associates with estrogen receptor alpha and might have a potential as prognostic or predictive marker in endometrial cancer PMID: 24053619
    10. Via obligate assistance of Scube1 and 3, Scube2 plays a center role to recruit dually lipid-modified Hedgehog transferred from Dispatched A (DispA), increasing Hh secretion by promoting its solubility. PMID: 24084593
    11. Domain and functional analysis of a novel breast tumor suppressor protein, SCUBE2. PMID: 21652720
    12. identification as secreted protein that is expressed in vascular endothelium and may play important roles in development, inflammation, and thrombosis PMID: 12270931
    13. Altered SCUBE2 expression is important in breast cancer progression and SCUBE2 may serve as a useful prognostic marker. PMID: 19369267
    14. The full-length cDNA of human SCUBE2 was isolated and the role in the hedgehog signalling cascade, was studied. PMID: 19480626

    顯示更多

    收起更多

  • 亞細胞定位：
    Secreted. Cell surface.
  • 組織特異性：
    Expressed in a broad spectrum of adult tissues.
  • 數據庫鏈接：

    HGNC: 30425

    OMIM: 611747

    KEGG: hsa:57758

    UniGene: Hs.523468



主站蜘蛛池模板： 伊人成年网站综合网| 成人性生交大片免费卡看| 国产精品白浆一区二小说| 欧美大黑帍在线播放| 亚洲已满18点击进入在线观看 | 免费乱码人妻系列无码专区| .精品久久久麻豆国产精品| 亚洲国产成人av在线观看| 欧美人禽杂交狂配免费看| 精品一区二区三区在线播放视频| 国产一性一交一伦一a片| 亚洲乱亚洲乱妇| 伊人蕉影院久亚洲高清| 中文字幕无码无码专区| 狠狠色噜噜狠狠狠8888米奇| 国产精品久久久久秋霞鲁丝| 黑人与人妻无码中字视频| 14萝自慰专用网站| 人妻丰满熟妇av无码区不卡| 翘臀后进少妇大白嫩屁股| 国产99爱在线视频免费观看| 99久久精品无码一区二区三区 | 全部免费毛片在线播放| 上司揉捏人妻丰满双乳电影| 人妻性奴波多野结衣无码| 亚洲丰满熟女一区二区v| 亚洲一线二线三线写真| 亚洲乱码日产精品bd| 初尝黑人巨砲波多野结衣| 日本伊人色综合网| 欧美成人a天堂片在线观看| 亚洲人成在线观看网站无码| 国产免费又爽又色又粗视频| 2019最新久久久视频精品| 好男人在在线社区www在线影院| 夜夜躁狠狠躁日日躁| 中文人妻av久久人妻18| 久久人人97超碰a片精品| 亚洲色欲综合一区二区三区| 亚洲人妻av伦理| 亚洲爆乳www无码专区|