在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. SCUBE2 Antibody, Biotin conjugated

SCUBE2 Antibody, Biotin conjugated

  • 中文名稱：
    SCUBE2兔多克隆抗體, Biotin偶聯
  • 貨號：
    CSB-PA865101LD01HU
  • 規格：
    ￥880
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) SCUBE2 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    SCUBE2
  • 別名：
    4932442O19Rik antibody; Cegb1 antibody; Cegf1 antibody; CEGP1 antibody; Cegp1 protein antibody; CUB domain and EGF-like repeat containing 1 antibody; FLJ16792 antibody; FLJ35234 antibody; ICRFP703B1614Q5.1 antibody; MGC133057 antibody; Protein CEGP1 antibody; RGD1563998 antibody; SCUB2_HUMAN antibody; Scube2 antibody; Signal peptide; CUB and EGF-like domain-containing protein 2 antibody; Signal peptide; CUB domain; EGF-like 2 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Signal peptide, CUB and EGF-like domain-containing protein 2 protein (534-703AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Biotin
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Lipid-binding protein required for SHH long-range signaling by binding to the dually lipid-modified SHH (ShhNp) and by promoting ShhNp mobilization, solubilization and release from the cell membrane. Acts by enhancing the proteolytic processing (shedding) of the lipid-modified N- and C- terminal of ShhNp at the cell surface. Synergizes with DISP1 to increase SHH secretion. Probable cell surface coreceptor for VEGFR2 involved in VEGFR2-mediated angiogenesis.
  • 基因功能參考文獻：
    1. Overexpression of SCUBE2 inhibits non-small cell lung cancer cell proliferation and invasion through suppressing the Sonic hedgehog signaling pathway. PMID: 29883759
    2. Results confirm that heparan sulfate (HS) proteoglycans enrich Scube2 at the surface of Shh-producing cells and that Scube2-regulated proteolytic Shh processing and release depends on specific HS. PMID: 27199253
    3. Endothelial SCUBE2 may be a novel coreceptor for VEGFR2 and potentiate VEGF-induced signaling in adult angiogenesis. PMID: 27834687
    4. The Sonic hedgehog (Shh) signaling pathway was involved in the inhibitory effect of SCUBE2 overexpression on glioma cells. PMID: 27697090
    5. Overexpression of SCUBE2 is associated with Breast Cancer Recurrence. PMID: 27165221
    6. SCUBE2 expression was decreased at the transcriptional and translational levels in colorectal cancer tissues and significantly associated with clinical stage, the depth of tumor invasion, lymphnode metastasis, distant metastasis and histological grade. PMID: 25672935
    7. Sheddases and Scube2 act cooperatively to increase the pool of soluble bioactive Shh. PMID: 24522195
    8. Tumor suppressor SCUBE2 inhibits breast-cancer cell migration and invasion through the reversal of epithelial-mesenchymal transition. PMID: 24213532
    9. data suggest that signal peptide CUB domain (SCUBE2), like in breast cancer, associates with estrogen receptor alpha and might have a potential as prognostic or predictive marker in endometrial cancer PMID: 24053619
    10. Via obligate assistance of Scube1 and 3, Scube2 plays a center role to recruit dually lipid-modified Hedgehog transferred from Dispatched A (DispA), increasing Hh secretion by promoting its solubility. PMID: 24084593
    11. Domain and functional analysis of a novel breast tumor suppressor protein, SCUBE2. PMID: 21652720
    12. identification as secreted protein that is expressed in vascular endothelium and may play important roles in development, inflammation, and thrombosis PMID: 12270931
    13. Altered SCUBE2 expression is important in breast cancer progression and SCUBE2 may serve as a useful prognostic marker. PMID: 19369267
    14. The full-length cDNA of human SCUBE2 was isolated and the role in the hedgehog signalling cascade, was studied. PMID: 19480626

    顯示更多

    收起更多

  • 亞細胞定位：
    Secreted. Cell surface.
  • 組織特異性：
    Expressed in a broad spectrum of adult tissues.
  • 數據庫鏈接：

    HGNC: 30425

    OMIM: 611747

    KEGG: hsa:57758

    UniGene: Hs.523468



主站蜘蛛池模板： 亚洲日韩成人av无码网站| 免费一区二区无码东京热| 97久久综合亚洲色hezyo| 激情综合色综合啪啪开心| 国产成人精品午夜福利在线播放| 无码无套少妇18p在线直播| 国产性色播播毛片| www国产亚洲精品| 天堂mv在线mv免费mv香蕉| 亚洲欧美综合精品久久成人网| 特黄三级又爽又粗又大| 女厕偷窥一区二区三区| 老湿机69福利区18禁网站| 天堂岛国av无码免费无禁网站| 99偷拍视频精品一区二区| 国产超碰人人模人人爽人人添| 国产精品情侣呻吟对白视频| 精品第一国产综合精品蜜芽| 色欲香天天综合网站| 精品国偷自产在线视频| 狠狠色狠狠色综合日日不卡 | 亚洲日韩精品一区二区三区无码 | 男人扒开女人双腿猛进免费视频 | 久久综合九色综合欧美狠狠| 亚洲精品一线二线三线区别大吗 | 国产av人人夜夜澡人人爽麻豆 | 麻豆果冻国产剧情av在线播放| 欧美人与动牲交免费观看网| 76少妇精品导航| 97一区二区国产好的精华液| 99在线 | 亚洲| 亚洲欧美日韩一区在线观看 | 丁香狠狠色婷婷久久综合| 国产成人无码一区二区三区| 爆爽久久久一区二区又大又黄又嫩| 动漫无遮挡羞视频在线观看| 国产精品无码嫩草地址更新| 人妻激情另类乱人伦人妻| 国产日韩另类综合11页| 潮喷大喷水系列无码| 久久欧美与黑人双交男男|