在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

SARS Antibody

  • 中文名稱:
    SARS兔多克隆抗體
  • 貨號(hào):
    CSB-PA020709GA01HU
  • 規(guī)格:
    ¥3,900
  • 其他:

產(chǎn)品詳情

  • Uniprot No.:
  • 基因名:
    SARS
  • 別名:
    C78314 antibody; cytoplasmic antibody; EC 6.1.1.11 antibody; FLJ36399 antibody; sarS antibody; Sars1 antibody; Serine tRNA ligase 1, cytoplasmic antibody; Serine tRNA ligase antibody; Serine--tRNA ligase antibody; serine--tRNA ligase, cytoplasmic antibody; SerRS antibody; SERS antibody; Seryl tRNA Ser/Sec synthetase antibody; Seryl tRNA synthetase antibody; Seryl tRNA synthetase cytoplasmic antibody; Seryl-tRNA Ser/Sec synthetase antibody; Seryl-tRNA synthetase antibody; seryl-tRNA synthetase, cytoplasmic antibody; Seryl-tRNA(Ser/Sec) synthetase antibody; Strs antibody; SYSC_HUMAN antibody
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human,Mouse,Rat
  • 免疫原:
    Human SARS
  • 免疫原種屬:
    Homo sapiens (Human)
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產(chǎn)品提供形式:
    Liquid
  • 應(yīng)用范圍:
    ELISA,WB,IHC
  • Protocols:
  • 儲(chǔ)存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能:
    Catalyzes the attachment of serine to tRNA(Ser) in a two-step reaction: serine is first activated by ATP to form Ser-AMP and then transferred to the acceptor end of tRNA(Ser). Is probably also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec). In the nucleus, binds to the VEGFA core promoter and prevents MYC binding and transcriptional activation by MYC. Recruits SIRT2 to the VEGFA promoter, promoting deacetylation of histone H4 at 'Lys-16' (H4K16). Thereby, inhibits the production of VEGFA and sprouting angiogenesis mediated by VEGFA.
  • 基因功能參考文獻(xiàn):
    1. Here, we report on mutations in two aminoacyl-tRNA synthetases that are associated with Intellectual disability (ID) in two unrelated Iranian families. In the first family, we identified a homozygous missense mutation (c.514G>A, p.Asp172Asn) in the cytoplasmic seryl-tRNA synthetase (SARS) gene PMID: 28236339
    2. Analyzed the ability of cytosolic SerRS to bind and act on tRNA(Ser), tRNA(Sec), and 10 mutant and chimeric constructs in which elements of tRNA(Ser) were transposed onto tRNA(Sec). We show that SerRS only subtly prefers tRNA(Ser) to tRNA(Sec), and that discrimination occurs at the level of the serylation reaction. PMID: 28808125
    3. Yin Yang 1 (YY1) interacts with Seryl-tRNA synthetase (SerRS) to form a SerRS/YY1 complex which functions as a negative effector to regulate vegfa transcription through binding a distal segment of the vegfa promoter, while NFKB1 serves as a positive effector through outcompeting SerRS/YY1 for binding at the same distal segment. PMID: 27913726
    4. tRNA recognition mode of SerRS. PMID: 26433229
    5. Several data support that p.R402H mutation in SARS2 is a new cause of HUPRA syndrome. PMID: 24034276
    6. A long-range conformational and functional communication specific to higher eukaryotes is found in human SerRS. PMID: 24095058
    7. study identified a nuclear localization signal sequence embedded in UNE-S domain and showed that the essential role of SerRS in vascular development is dependent on UNE-S and its role to mobilize SerRS from the cytoplasm to the nucleus PMID: 22353712
    8. Mutations in the mitochondrial seryl-tRNA synthetase cause hyperuricemia, pulmonary hypertension, renal failure in infancy and alkalosis, HUPRA syndrome. PMID: 21255763
    9. Recombinant human cytosolic seryl-tRNA synthetase protein was purified to homogeneity and crystallized. Diffraction data were collected to 3.13 A resolution. PMID: 21045311
    10. SARS regulates endothelial sprouting. These analyses of zebrafish and human endothelial cells reveal a new noncanonical function of Sars in endothelial development. PMID: 19423847

    顯示更多

    收起更多

  • 亞細(xì)胞定位:
    Cytoplasm. Nucleus.
  • 蛋白家族:
    Class-II aminoacyl-tRNA synthetase family, Type-1 seryl-tRNA synthetase subfamily
  • 組織特異性:
    Brain.
  • 數(shù)據(jù)庫鏈接:

    HGNC: 10537

    OMIM: 607529

    KEGG: hsa:6301

    STRING: 9606.ENSP00000234677

    UniGene: Hs.531176



主站蜘蛛池模板: 亚洲精品美女久久7777777| 人人爽人人爽人人片a| 久久久久久国产精品免费免费男同 | 强迫大乳人妻中文字幕| 亚洲乱码av中文一区二区软件 | 伊人久久大香线蕉av一区| 久久久精品欧美一区二区免费| 久久三级中文欧大战字幕| 精品日产高清卡4卡5区别| 中字幕一区二区三区乱码| 无码日韩人妻精品久久蜜桃| 日韩精品毛片无码一区到三区| 呻吟国产av久久一区二区| 999成人精品视频在线| 精品国产天堂综合一区在线| av无码一区二区三区| 无码专区男人本色| 人人妻人人爽人人澡欧美一区| 久久青草成人综合网站| 粗大的内捧猛烈进出视频| 女人大荫蒂毛茸茸视频| 无码免费午夜福利看片| 天堂在/线资源中文在线8| 中文字幕无码家庭乱欲| 久久久久成人精品无码| 亚洲三区在线观看内射后入| 免费国产成人高清在线视频 | 亚洲一区二区观看播放| 成 人 色综合 综合网站| 色窝窝免费播放视频在线| 亚洲国产区男人本色| 18禁免费观看网站| 香蕉欧美成人精品a∨在线观看 | 丰满人妻妇伦又伦精品国产| 亚洲欧洲日产国码韩国| 亚洲色成人一区二区三区| 超碰免费公开| 亚洲性无码av在线欣赏网| 国产精品成人片在线观看| 亚洲精品久久久久国产剧8| 亚洲中文无码av在线|