在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

SARS Antibody, HRP conjugated

  • 中文名稱:
    SARS兔多克隆抗體, HRP偶聯(lián)
  • 貨號(hào):
    CSB-PA04145B0Rb
  • 規(guī)格:
    ¥880
  • 其他:

產(chǎn)品詳情

  • 產(chǎn)品名稱:
    Rabbit anti-Homo sapiens (Human) SARS Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    SARS
  • 別名:
    C78314 antibody; cytoplasmic antibody; EC 6.1.1.11 antibody; FLJ36399 antibody; sarS antibody; Sars1 antibody; Serine tRNA ligase 1, cytoplasmic antibody; Serine tRNA ligase antibody; Serine--tRNA ligase antibody; serine--tRNA ligase, cytoplasmic antibody; SerRS antibody; SERS antibody; Seryl tRNA Ser/Sec synthetase antibody; Seryl tRNA synthetase antibody; Seryl tRNA synthetase cytoplasmic antibody; Seryl-tRNA Ser/Sec synthetase antibody; Seryl-tRNA synthetase antibody; seryl-tRNA synthetase, cytoplasmic antibody; Seryl-tRNA(Ser/Sec) synthetase antibody; Strs antibody; SYSC_HUMAN antibody
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human
  • 免疫原:
    Recombinant Human Serine--tRNA ligase, cytoplasmic protein (2-233AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標(biāo)記方式:
    HRP
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式:
    Liquid
  • 應(yīng)用范圍:
    ELISA
  • Protocols:
  • 儲(chǔ)存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能:
    Catalyzes the attachment of serine to tRNA(Ser) in a two-step reaction: serine is first activated by ATP to form Ser-AMP and then transferred to the acceptor end of tRNA(Ser). Is probably also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec). In the nucleus, binds to the VEGFA core promoter and prevents MYC binding and transcriptional activation by MYC. Recruits SIRT2 to the VEGFA promoter, promoting deacetylation of histone H4 at 'Lys-16' (H4K16). Thereby, inhibits the production of VEGFA and sprouting angiogenesis mediated by VEGFA.
  • 基因功能參考文獻(xiàn):
    1. Here, we report on mutations in two aminoacyl-tRNA synthetases that are associated with Intellectual disability (ID) in two unrelated Iranian families. In the first family, we identified a homozygous missense mutation (c.514G>A, p.Asp172Asn) in the cytoplasmic seryl-tRNA synthetase (SARS) gene PMID: 28236339
    2. Analyzed the ability of cytosolic SerRS to bind and act on tRNA(Ser), tRNA(Sec), and 10 mutant and chimeric constructs in which elements of tRNA(Ser) were transposed onto tRNA(Sec). We show that SerRS only subtly prefers tRNA(Ser) to tRNA(Sec), and that discrimination occurs at the level of the serylation reaction. PMID: 28808125
    3. Yin Yang 1 (YY1) interacts with Seryl-tRNA synthetase (SerRS) to form a SerRS/YY1 complex which functions as a negative effector to regulate vegfa transcription through binding a distal segment of the vegfa promoter, while NFKB1 serves as a positive effector through outcompeting SerRS/YY1 for binding at the same distal segment. PMID: 27913726
    4. tRNA recognition mode of SerRS. PMID: 26433229
    5. Several data support that p.R402H mutation in SARS2 is a new cause of HUPRA syndrome. PMID: 24034276
    6. A long-range conformational and functional communication specific to higher eukaryotes is found in human SerRS. PMID: 24095058
    7. study identified a nuclear localization signal sequence embedded in UNE-S domain and showed that the essential role of SerRS in vascular development is dependent on UNE-S and its role to mobilize SerRS from the cytoplasm to the nucleus PMID: 22353712
    8. Mutations in the mitochondrial seryl-tRNA synthetase cause hyperuricemia, pulmonary hypertension, renal failure in infancy and alkalosis, HUPRA syndrome. PMID: 21255763
    9. Recombinant human cytosolic seryl-tRNA synthetase protein was purified to homogeneity and crystallized. Diffraction data were collected to 3.13 A resolution. PMID: 21045311
    10. SARS regulates endothelial sprouting. These analyses of zebrafish and human endothelial cells reveal a new noncanonical function of Sars in endothelial development. PMID: 19423847

    顯示更多

    收起更多

  • 亞細(xì)胞定位:
    Cytoplasm. Nucleus.
  • 蛋白家族:
    Class-II aminoacyl-tRNA synthetase family, Type-1 seryl-tRNA synthetase subfamily
  • 組織特異性:
    Brain.
  • 數(shù)據(jù)庫鏈接:

    HGNC: 10537

    OMIM: 607529

    KEGG: hsa:6301

    STRING: 9606.ENSP00000234677

    UniGene: Hs.531176



主站蜘蛛池模板: 国产成人欧美日韩在线电影| 全黄激性性视频| 亚洲偷自拍国综合| 色先锋影音岛国av资源| 久久天堂av综合合色| 99久久99久久精品免费看蜜桃| 亚洲国产成人久久一区二区三区| 欧美日韩不卡高清在线看| 久久66热人妻偷产精品9| 综合亚洲伊人午夜网| 人妻人人做人做人人爱| 国产精品青青在线麻豆| 校花高潮抽搐冒白浆| 欧美精品黑人粗大视频| 精品人体无码一区二区三区| www激情内射在线看| 无码大潮喷水在线观看| 女人高潮内射99精品 | 成人综合网亚洲伊人| 亚洲愉拍99热成人精品热久久 | 日本熟妇色一本在线观看| 特级a欧美做爰片第一次| 午夜成人鲁丝片午夜精品| 日韩精品一区二区三区中文| 国产成人无码午夜福利在线直播| 极品人妻少妇一区二区三区| 国产成人精品日本亚洲第一区| 国产 精品 自在 线免费| 99re久久热在这里精品| 中文字幕av一区二区三区| 内射毛片内射国产夫妻| 国产精品美女久久久网站动漫| 亚洲综合中文字幕无线码| 少妇人妻邻居| 国产香蕉尹人在线视频你懂的| 中文字幕无码中文字幕有码a| 久久久亚洲一区二区三区| 人与动人物xxxx毛片人与狍 | 国产啪精品视频网站| 日日碰狠狠躁久久躁96avv| 免费va人成视频网站全|