在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

S1PR4 Antibody

  • 中文名稱:
    S1PR4兔多克隆抗體
  • 貨號:
    CSB-PA580045
  • 規格:
    ¥1100
  • 圖片:
    • Gel: 10%SDS-PAGE, Lysate: 50 μg, Lane: Rat kidney tissue, Primary antibody: CSB-PA580045(S1PR4 Antibody) at dilution 1/250, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 20 seconds
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
  • 別名:
    S1PR4; EDG6; Sphingosine 1-phosphate receptor 4; S1P receptor 4; S1P4; Endothelial differentiation G-protein coupled receptor 6; Sphingosine 1-phosphate receptor Edg-6; S1P receptor Edg-6
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Synthetic peptide of Human S1PR4
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen affinity purification
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB
  • 推薦稀釋比:
    Application Recommended Dilution
    ELISA 1:1000-1:2000
    WB 1:200-1:1000
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. May be involved in cell migration processes that are specific for lymphocytes.
  • 基因功能參考文獻:
    1. High S1PR4 expression is associated with anti-neutrophil cytoplasmic antibody-associated vasculitis. PMID: 28206609
    2. S1PR4 missense mutation is associated with variant blood cell traits. PMID: 27399967
    3. Shear stress did not induce rapid dephosphorylation of beta-arrestin-1 or rapid internalization of S1P3, indicating no GPCR activation. These findings suggest that Galphaq/11 participates in the sensing/transducing of shear stress independently of GPCR activation in ECs. PMID: 28148497
    4. Ig-like transcript 7 is rapidly internalized upon receptor-mediated endocytosis of TLR7/9 ligands to allow high IFN-alpha production. This is antagonized by S1PR4 signaling, thus decreasing TLR-induced IFN-alpha secretion. PMID: 26783340
    5. S1P2 translocation to the nucleus is regulated by an autocrine loop involving S1P and S1P4. In contrast, the translocation of Y416 phosphorylated c-Src to the nucleus appears to be regulated by a mechanism that does not involve S1P3 or S1P4. PMID: 24486401
    6. analysis of novel potent and selective sphingosine-1-phosphate 4 receptor (S1P-R) agonists PMID: 22119461
    7. findings highlight an important role for S1P(4) and SK1 in ER(-) breast cancer progression. PMID: 22460268
    8. Data show that S1P4 uses HER2 to regulate extracellular signal regulated kinase-1/2 MDA-MB-453 breast cancer cells. PMID: 20837468
    9. Data report that sphingosine 1-phosphate receptor 4 (S1P(4)) is specifically up-regulated during the development of human megakaryocytes from progenitor cells PMID: 20686109
    10. Mutation of the ligand selectivity residue from glutamic acid to glutamine confers lysophosphatidic acid sensitivity with preference for short-chain species PMID: 15298705
    11. FOXO1 controls the expression of L-selectin and EDG1 and EDG6, receptors that regulate lymphocyte trafficking PMID: 18713968

    顯示更多

    收起更多

  • 亞細胞定位:
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族:
    G-protein coupled receptor 1 family
  • 組織特異性:
    Specifically expressed in fetal and adult lymphoid and hematopoietic tissue as well as in lung. Considerable level of expression in adult and fetal spleen as well as adult peripheral leukocytes and lung. Lower expression in adult thymus, lymph node, bone
  • 數據庫鏈接:

    HGNC: 3170

    OMIM: 603751

    KEGG: hsa:8698

    STRING: 9606.ENSP00000246115

    UniGene: Hs.662006



主站蜘蛛池模板: 天天躁日日躁狠狠久久| 97无码精品综合| 天天噜噜噜在线视频| 日韩高清国产一区在线| 男女猛烈无遮挡免费视频app| 国产伦精品一区二区三区妓女下载| 久久国产中文娱乐网| 超碰成人人人做人人爽| 人妻av中文字幕一区二区三区| 黑人糟蹋人妻hd中文字幕| 国产熟妇按摩3p高潮大叫| 亚洲综合成人av一区在线观看| 无码h黄肉动漫在线观看| 久久综合色鬼综合色| 国产精品99无码一区二区| 久久精品国产亚洲αv忘忧草| 日韩69永久免费视频| 欧美一区二区三区视频在线观看| 国产av国片精品| 开心五月激情综合婷婷色| 亚洲日韩国产精品无码av| 久久久水蜜桃国产成人网站| 日韩精品一区二区三区中文| 国产97色在线 | 亚洲| 极品少妇小泬50pthepon| 又爽又黄又无遮挡的激情视频| 久久午夜私人影院| 久久久亚洲精品无码| 无码熟妇人妻av在线影片| 免费看又黄又无码的网站| 精品日产一卡2卡三卡4卡在线| 国产超碰人人做人人爽av大片| 免费看无码自慰一区二区| 国产亚洲情侣一区二区无| 中文字幕无码一区二区免费| 亚洲国产av美女网站| 亚洲午夜福利在线视频| 国产无遮挡a片又黄又爽漫画| 香蕉97超级碰碰碰视频| 中文av岛国无码免费播放| 国产精品卡一卡二卡三|