在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

S1PR4 Antibody

  • 中文名稱:
    S1PR4兔多克隆抗體
  • 貨號:
    CSB-PA002251
  • 規格:
    ¥1090
  • 圖片:
    • Western Blot analysis of HepG2 cells using EDG-6 Polyclonal Antibody
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
  • 別名:
    S1PR4; EDG6; Sphingosine 1-phosphate receptor 4; S1P receptor 4; S1P4; Endothelial differentiation G-protein coupled receptor 6; Sphingosine 1-phosphate receptor Edg-6; S1P receptor Edg-6
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Synthesized peptide derived from the Internal region of Human EDG-6.
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    WB, IF, ELISA
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:2000
    IF 1:200-1:1000
    ELISA 1:5000
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. May be involved in cell migration processes that are specific for lymphocytes.
  • 基因功能參考文獻:
    1. High S1PR4 expression is associated with anti-neutrophil cytoplasmic antibody-associated vasculitis. PMID: 28206609
    2. S1PR4 missense mutation is associated with variant blood cell traits. PMID: 27399967
    3. Shear stress did not induce rapid dephosphorylation of beta-arrestin-1 or rapid internalization of S1P3, indicating no GPCR activation. These findings suggest that Galphaq/11 participates in the sensing/transducing of shear stress independently of GPCR activation in ECs. PMID: 28148497
    4. Ig-like transcript 7 is rapidly internalized upon receptor-mediated endocytosis of TLR7/9 ligands to allow high IFN-alpha production. This is antagonized by S1PR4 signaling, thus decreasing TLR-induced IFN-alpha secretion. PMID: 26783340
    5. S1P2 translocation to the nucleus is regulated by an autocrine loop involving S1P and S1P4. In contrast, the translocation of Y416 phosphorylated c-Src to the nucleus appears to be regulated by a mechanism that does not involve S1P3 or S1P4. PMID: 24486401
    6. analysis of novel potent and selective sphingosine-1-phosphate 4 receptor (S1P-R) agonists PMID: 22119461
    7. findings highlight an important role for S1P(4) and SK1 in ER(-) breast cancer progression. PMID: 22460268
    8. Data show that S1P4 uses HER2 to regulate extracellular signal regulated kinase-1/2 MDA-MB-453 breast cancer cells. PMID: 20837468
    9. Data report that sphingosine 1-phosphate receptor 4 (S1P(4)) is specifically up-regulated during the development of human megakaryocytes from progenitor cells PMID: 20686109
    10. Mutation of the ligand selectivity residue from glutamic acid to glutamine confers lysophosphatidic acid sensitivity with preference for short-chain species PMID: 15298705
    11. FOXO1 controls the expression of L-selectin and EDG1 and EDG6, receptors that regulate lymphocyte trafficking PMID: 18713968

    顯示更多

    收起更多

  • 亞細胞定位:
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族:
    G-protein coupled receptor 1 family
  • 組織特異性:
    Specifically expressed in fetal and adult lymphoid and hematopoietic tissue as well as in lung. Considerable level of expression in adult and fetal spleen as well as adult peripheral leukocytes and lung. Lower expression in adult thymus, lymph node, bone
  • 數據庫鏈接:

    HGNC: 3170

    OMIM: 603751

    KEGG: hsa:8698

    STRING: 9606.ENSP00000246115

    UniGene: Hs.662006



主站蜘蛛池模板: 日韩精品一区二区三区中文| 国产成人无码a区在线观看视频 | 国产md视频一区二区三区| 国产精品天天看特色大片| 男人j进入女人j内部免费网站| 精品无码中文视频在线观看| 国产精品成人嫩草影院| 亚洲一卡2卡三卡4卡国色天香| 婷婷伊人五月尤物| 乱色熟女综合一区二区三区| 久久久噜噜噜久噜久久| 欧洲精品一卡2卡三卡4卡影视| 久9热视频这里只精品18| 天天躁日日躁狠狠躁av| 内射人妻无套中出无码| 无套内射chinesehd熟女| 337p日本欧洲亚洲大胆精品| 乱熟女高潮一区二区在线| 拍国产乱人伦偷精品视频| 在线观看国产日韩亚洲中| 亚洲精品国男人在线视频| 一道久久爱综合久久爱| 校园春色~综合网| 不卡无码人妻一区三区音频| 国产高清乱理伦片中文小说| 国产精品原创巨作av| 国产成人综合色视频精品| 久久超碰极品视觉盛宴| 国产色婷婷亚洲99精品小说| 蜜臀av色欲a片无码精品一区| 日本韩国的免费观看视频| 欧美日韩国产综合新一区| 久久久精品波多野结衣| 国产高潮抽搐喷水高清| 亚洲1卡二卡三新区2022| 欧美成人午夜精品久久久| 国产亚洲无线码一区二区| 一本大道东京热无码视频| 国内精品久久久久久久97牛牛| 性xxxx欧美老妇胖老太269| 人妻无码少妇一区二区|