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  4. S100A16 Antibody

S100A16 Antibody

  • 中文名稱：
    S100A16兔多克隆抗體
  • 貨號：
    CSB-PA113412
  • 規(guī)格：
    ￥2024
  • 圖片：
    • Western blot analysis of extracts from 3T3 cells and RAW264.7 cells, using S100A16 antibody.
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) S100A16 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    S100A16
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human,Rat
  • 免疫原：
    Synthesized peptide derived from internal of Human S100A16.
  • 免疫原種屬：
    Homo sapiens (Human)
  • 克隆類型：
    Polyclonal
  • 純化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA,WB
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:3000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    Calcium-binding protein. Binds one calcium ion per monomer. Can promote differentiation of adipocytes (in vitro). Overexpression in preadipocytes increases their proliferation, enhances adipogenesis and reduces insulin-stimulated glucose uptake.
  • 基因功能參考文獻：
    1. Low S100A16 expression is associated with colorectal cancer. PMID: 28876468
    2. Data show that overexpression of S100 calcium binding protein A16 protein (S100A16) activated AKT protein and ERK signaling pathways. PMID: 27240591
    3. These results indicate that S100 calcium binding protein A16 is a differentiation promoting protein and might function as a tumor suppressor in oral squamous cell carcinoma. PMID: 26353754
    4. S100A16 had a potential function to regulate some embryonic transcription factors to promote epithelial-mensenchymal transition in breast cancer cells which may be an important target site for the therapy of breast cancer. PMID: 25287362
    5. The presence of hydrophobic interactions stronger than for other S100 proteins, present in the closed form of S100A16 between the third and fourth helices, likely make the closed structure of the second EF-hand particularly stable. PMID: 21046186

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  • 亞細(xì)胞定位：
    Nucleus, nucleolus. Cytoplasm. Note=Primarily nucleolar. A high intracellular calcium level induces nucleolar exit and nucleocytoplasmic transport, whereas a low intracellular calcium level leads to nuclear translocation and accumulation within specific region of nucleoli (PubMed:17030513).
  • 蛋白家族：
    S-100 family
  • 組織特異性：
    Ubiquitous. Highly expressed in esophagus, adipose tissues and colon. Expressed at lower level in lung, brain, pancreas and skeletal muscle. Expression is up-regulated in tumors of bladder, lung, thyroid gland, pancreas and ovary. Expressed in astrocytes.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 20441

    OMIM: 617437

    KEGG: hsa:140576

    STRING: 9606.ENSP00000357692

    UniGene: Hs.515714



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