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RTTN Antibody, FITC conjugated

  • 中文名稱:
    RTTN兔多克隆抗體, FITC偶聯
  • 貨號:
    CSB-PA020581LC01HU
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) RTTN Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    RTTN
  • 別名:
    DKFZP434G145 antibody; Rotatin antibody; Rttn antibody; RTTN_HUMAN antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Rotatin protein (1509-1603AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    FITC
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式:
    Liquid
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Involved in the genetic cascade that governs left-right specification. Plays a role in the maintenance of a normal ciliary structure. Required for correct asymmetric expression of NODAL, LEFTY and PITX2.
  • 基因功能參考文獻:
    1. RTTN directly interacts with STIL and acts downstream of STIL-mediated centriole assembly, contributing to building full-length centrioles. PMID: 28811500
    2. We found a novel homozygous mutation in RTTN associated with microcephalic PD as well as complex brain malformations and congenital dermatitis, thus expanding the phenotypic spectrum of both RTTN-associated diseases and ciliary dysfunction. PMID: 26940245
    3. RTTN mutations cause primary microcephaly and primordial dwarfism in humans. PMID: 26608784
    4. RTTN mutations therefore link aberrant ciliary function to abnormal development and organization of the cortex in human individuals. PMID: 22939636
    5. Study characterizing mouse rotatin gene. PMID: 11900971

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  • 相關疾?。?/div>
    Microcephaly, short stature, and polymicrogyria with or without seizures (MSSP)
  • 亞細胞定位:
    Cytoplasm, cytoskeleton, cilium basal body. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Colocalizes with the basal bodies at the primary cilium.
  • 數據庫鏈接:

    HGNC: 18654

    OMIM: 610436

    KEGG: hsa:25914

    STRING: 9606.ENSP00000255674

    UniGene: Hs.654809



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