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  4. RTTN Antibody, Biotin conjugated

RTTN Antibody, Biotin conjugated

  • 中文名稱：
    RTTN兔多克隆抗體, Biotin偶聯(lián)
  • 貨號：
    CSB-PA020581LD01HU
  • 規(guī)格：
    ￥880
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) RTTN Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    RTTN
  • 別名：
    DKFZP434G145 antibody; Rotatin antibody; Rttn antibody; RTTN_HUMAN antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human Rotatin protein (1509-1603AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Biotin
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價(jià)

靶點(diǎn)詳情

  • 功能：
    Involved in the genetic cascade that governs left-right specification. Plays a role in the maintenance of a normal ciliary structure. Required for correct asymmetric expression of NODAL, LEFTY and PITX2.
  • 基因功能參考文獻(xiàn)：
    1. RTTN directly interacts with STIL and acts downstream of STIL-mediated centriole assembly, contributing to building full-length centrioles. PMID: 28811500
    2. We found a novel homozygous mutation in RTTN associated with microcephalic PD as well as complex brain malformations and congenital dermatitis, thus expanding the phenotypic spectrum of both RTTN-associated diseases and ciliary dysfunction. PMID: 26940245
    3. RTTN mutations cause primary microcephaly and primordial dwarfism in humans. PMID: 26608784
    4. RTTN mutations therefore link aberrant ciliary function to abnormal development and organization of the cortex in human individuals. PMID: 22939636
    5. Study characterizing mouse rotatin gene. PMID: 11900971

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  • 相關(guān)疾病：
    Microcephaly, short stature, and polymicrogyria with or without seizures (MSSP)
  • 亞細(xì)胞定位：
    Cytoplasm, cytoskeleton, cilium basal body. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Colocalizes with the basal bodies at the primary cilium.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 18654

    OMIM: 610436

    KEGG: hsa:25914

    STRING: 9606.ENSP00000255674

    UniGene: Hs.654809



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