在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. RRAGC Antibody

RRAGC Antibody

  • 中文名稱：
    RRAGC兔多克隆抗體
  • 貨號：
    CSB-PA867190ESR1HU
  • 規格：
    ￥440
  • 圖片：
    • Western blot
      All lanes: RRAGC antibody at 1.14µg/ml
      Lane 1: Hela whole cell lysate
      Lane 2: MCF-7 whole cell lysate
      Lane 3: A549 whole cell lysate
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 44 kDa
      Observed band size: 44 kDa
    • Immunohistochemistry of paraffin-embedded human adrenal gland tissue using CSB-PA867190ESR1HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human small intestine tissue using CSB-PA867190ESR1HU at dilution of 1:100
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) RRAGC Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    AU041672 antibody; FLJ13311 antibody; GTPase interacting protein 2 antibody; GTPase-interacting protein 2 antibody; GTR2 antibody; MGC47404 antibody; OTTHUMP00000000548 antibody; Rag C antibody; Rag C protein antibody; RAGC antibody; Ras related GTP binding C antibody; Ras-related GTP-binding protein C antibody; RP23 29H22.4 antibody; RRAGC antibody; RRAGC_HUMAN antibody; TIB929 antibody; YGR163W antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Ras-related GTP-binding protein C protein (1-250AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity Purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, WB, IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:1000-1:5000
    IHC 1:20-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade. Forms heterodimeric Rag complexes with RRAGA or RRAGB and cycles between an inactive GTP-bound and an active GDP-bound form. In its active form participates in the relocalization of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB. This is a crucial step in the activation of the TOR signaling cascade by amino acids.
  • 基因功能參考文獻：
    1. Multiple RRAGC mutations demonstrated elevated MTOR activation. PMID: 27267853
    2. Full-length RagA(GTP):RagC(GDP) dimer binds to regulator to activate mTORC1. PMID: 29107538
    3. The dynamic response of mTORC1 requires intersubunit communication by the Rag GTPases, providing a rationale for why they exist as a dimer and revealing a distinct mode of control for a GTP-binding protein. PMID: 29056322
    4. These findings implicate mTORC1 dysregulation through a gain-of-function mutation in RagC as a novel molecular basis for syndromic forms of pediatric heart failure, and expand genotype-phenotype correlation in RASopathy-related syndromes PMID: 27234373
    5. activating nature of the RRAGC mutations, their existence in the dominant clone and their stability during disease progression support their potential as an excellent candidate for therapeutic targeting PMID: 26691987

    顯示更多

    收起更多

  • 相關疾?。?/div>
    RRAGC mutations have been found in a patient with idiopathic dilated cardiomyopathy with ventricular dilation and systolic dysfunction, bilateral cataracts, and mild facial dysmorphisms.
  • 亞細胞定位：
    Cytoplasm. Nucleus. Lysosome.
  • 蛋白家族：
    GTR/RAG GTP-binding protein family
  • 數據庫鏈接：

    HGNC: 19902

    OMIM: 608267

    KEGG: hsa:64121

    STRING: 9606.ENSP00000362092

    UniGene: Hs.532461



主站蜘蛛池模板： 日本va欧美va欧美va精品| 亚洲人成电影在线天堂色 | 国产高清卡1卡2卡3麻豆| 俺去啦俺来也五月天| 在线播放亚洲人成电影| 国产98色在线 | 日韩| 久久天天躁夜夜躁狠狠85麻豆| 日本人妻人人人澡人人爽| 动漫精品无码h在线观看| 色婷婷亚洲一区二区综合| 亚洲第一无码精品立川理惠| 风流老熟女一区二区三区| 欧美乱强伦xxxxx高潮| 国产亚洲精品国产福利你懂的| 天码人妻一区二区三区| 少妇做爰免费视频了| 人妻少妇偷人精品无码| 性夜影院午夜看片| 国产午夜无码片在线观看网站| 成 人 网 站 免费观看| 少妇高潮喷水久久久影院| 免费无码一区二区三区a片| 2020最新无码国产在线观看| 久久综合色老色| 欧美va天堂在线电影| 色窝窝无码一区二区三区| 偷偷要色偷偷中文无码| 动漫成人无码精品一区二区三区 | 538prom精品视频在线播放| 久久99国产精品二区| 中文字幕在线日亚洲9| 国产超碰人人爽人人做| 欧美极p品少妇的xxxxx| 麻豆精品久久久久久中文字幕无码| 毛片内射久久久一区| 男人的天堂av网站| 无码国产精品高清免费| 99久久99久久免费精品蜜桃| 麻豆亚洲一区| 无码精品久久久久久人妻中字| 精品无码成人久久久久久|