在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. RRAGC Antibody

RRAGC Antibody

  • 中文名稱：
    RRAGC兔多克隆抗體
  • 貨號：
    CSB-PA867190ESR1HU
  • 規格：
    ￥440
  • 圖片：
    • Western blot
      All lanes: RRAGC antibody at 1.14µg/ml
      Lane 1: Hela whole cell lysate
      Lane 2: MCF-7 whole cell lysate
      Lane 3: A549 whole cell lysate
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 44 kDa
      Observed band size: 44 kDa
    • Immunohistochemistry of paraffin-embedded human adrenal gland tissue using CSB-PA867190ESR1HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human small intestine tissue using CSB-PA867190ESR1HU at dilution of 1:100
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) RRAGC Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    AU041672 antibody; FLJ13311 antibody; GTPase interacting protein 2 antibody; GTPase-interacting protein 2 antibody; GTR2 antibody; MGC47404 antibody; OTTHUMP00000000548 antibody; Rag C antibody; Rag C protein antibody; RAGC antibody; Ras related GTP binding C antibody; Ras-related GTP-binding protein C antibody; RP23 29H22.4 antibody; RRAGC antibody; RRAGC_HUMAN antibody; TIB929 antibody; YGR163W antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Ras-related GTP-binding protein C protein (1-250AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity Purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, WB, IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:1000-1:5000
    IHC 1:20-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade. Forms heterodimeric Rag complexes with RRAGA or RRAGB and cycles between an inactive GTP-bound and an active GDP-bound form. In its active form participates in the relocalization of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB. This is a crucial step in the activation of the TOR signaling cascade by amino acids.
  • 基因功能參考文獻：
    1. Multiple RRAGC mutations demonstrated elevated MTOR activation. PMID: 27267853
    2. Full-length RagA(GTP):RagC(GDP) dimer binds to regulator to activate mTORC1. PMID: 29107538
    3. The dynamic response of mTORC1 requires intersubunit communication by the Rag GTPases, providing a rationale for why they exist as a dimer and revealing a distinct mode of control for a GTP-binding protein. PMID: 29056322
    4. These findings implicate mTORC1 dysregulation through a gain-of-function mutation in RagC as a novel molecular basis for syndromic forms of pediatric heart failure, and expand genotype-phenotype correlation in RASopathy-related syndromes PMID: 27234373
    5. activating nature of the RRAGC mutations, their existence in the dominant clone and their stability during disease progression support their potential as an excellent candidate for therapeutic targeting PMID: 26691987

    顯示更多

    收起更多

  • 相關疾?。?/div>
    RRAGC mutations have been found in a patient with idiopathic dilated cardiomyopathy with ventricular dilation and systolic dysfunction, bilateral cataracts, and mild facial dysmorphisms.
  • 亞細胞定位：
    Cytoplasm. Nucleus. Lysosome.
  • 蛋白家族：
    GTR/RAG GTP-binding protein family
  • 數據庫鏈接：

    HGNC: 19902

    OMIM: 608267

    KEGG: hsa:64121

    STRING: 9606.ENSP00000362092

    UniGene: Hs.532461



主站蜘蛛池模板： 狠狠色综合网站久久久久久久高清| 国产在热线精品视频| 狂野欧美性猛交xxxx| 小泽玛莉亚一区二区视频在线| 在线 亚洲 国产 欧美| 99久久99视频只有精品| 亚洲一区二区三区偷拍女厕| 日本十八禁视频无遮挡| 日韩欧美群交p内射捆绑| 国内自拍久久久久影院| 色欲综合久久躁天天躁| 澳门永久av免费网站| 大香伊蕉在人线国产免费| 亚洲中文字幕久久精品无码va| 国产一卡二卡三新区2022| 蜜桃视频在线观看免费视频网站www| 寂寞少妇做spa按摩无码| 国产精品无打码在线播放| 天堂av成年av影视| 理论片午午伦夜理片影院99| 久久99精品久久久久久噜噜| 在线视频 亚太 国产 欧美 一区二区| 一区二区三区在线 | 日| 国产女人好紧好爽| 日本熟妇色xxxxxhd| 国产乱子伦一区二区三区视频播放| 日韩精品一区二区三区色欲av| 999国产精品999久久久久久| 国产精品主播一区二区三区 | 成人精品一区二区三区电影| 免费毛片a线观看| 九九视频麻婆豆腐在线观看| 国产妇女馒头高清泬20p多| 亚洲精品国产品国语在线观看| 中文字幕人妻被公上司喝醉| 国产免费午夜a无码v视频| 1000部啪啪未满十八勿入| 日日噜噜夜夜狠狠久久丁香五月| 国产亚洲999精品aa片在线爽| 国产精品福利视频导航| 久久综合久久美利坚合众国|