在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. RRAGC Antibody

RRAGC Antibody

  • 中文名稱：
    RRAGC兔多克隆抗體
  • 貨號(hào)：
    CSB-PA038367
  • 規(guī)格：
    ￥1100
  • 圖片：
    • Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-2: K562 cells, NIH/3T3 cells, Primary antibody: CSB-PA038367(RRAGC Antibody) at dilution 1/400, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 5 seconds
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
  • 別名：
    AU041672 antibody; FLJ13311 antibody; GTPase interacting protein 2 antibody; GTPase-interacting protein 2 antibody; GTR2 antibody; MGC47404 antibody; OTTHUMP00000000548 antibody; Rag C antibody; Rag C protein antibody; RAGC antibody; Ras related GTP binding C antibody; Ras-related GTP-binding protein C antibody; RP23 29H22.4 antibody; RRAGC antibody; RRAGC_HUMAN antibody; TIB929 antibody; YGR163W antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human,Mouse
  • 免疫原：
    Fusion protein of Human RRAGC
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen affinity purification
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA,WB
  • 推薦稀釋比：
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    WB 1:500-1:2000
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade. Forms heterodimeric Rag complexes with RRAGA or RRAGB and cycles between an inactive GTP-bound and an active GDP-bound form. In its active form participates in the relocalization of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB. This is a crucial step in the activation of the TOR signaling cascade by amino acids.
  • 基因功能參考文獻(xiàn)：
    1. Multiple RRAGC mutations demonstrated elevated MTOR activation. PMID: 27267853
    2. Full-length RagA(GTP):RagC(GDP) dimer binds to regulator to activate mTORC1. PMID: 29107538
    3. The dynamic response of mTORC1 requires intersubunit communication by the Rag GTPases, providing a rationale for why they exist as a dimer and revealing a distinct mode of control for a GTP-binding protein. PMID: 29056322
    4. These findings implicate mTORC1 dysregulation through a gain-of-function mutation in RagC as a novel molecular basis for syndromic forms of pediatric heart failure, and expand genotype-phenotype correlation in RASopathy-related syndromes PMID: 27234373
    5. activating nature of the RRAGC mutations, their existence in the dominant clone and their stability during disease progression support their potential as an excellent candidate for therapeutic targeting PMID: 26691987

    顯示更多

    收起更多

  • 相關(guān)疾?。?/div>
    RRAGC mutations have been found in a patient with idiopathic dilated cardiomyopathy with ventricular dilation and systolic dysfunction, bilateral cataracts, and mild facial dysmorphisms.
  • 亞細(xì)胞定位：
    Cytoplasm. Nucleus. Lysosome.
  • 蛋白家族：
    GTR/RAG GTP-binding protein family
  • 數(shù)據(jù)庫鏈接：

    HGNC: 19902

    OMIM: 608267

    KEGG: hsa:64121

    STRING: 9606.ENSP00000362092

    UniGene: Hs.532461



主站蜘蛛池模板： 国产欧美日韩专区发布| 日本不卡一区| www夜插内射视频网站| 黑鬼大战白妞高潮喷白浆| 国产嫖妓风韵犹存对白| 人妻出轨av中文字幕| 欧美成aⅴ人高清ww| 久久精品国产一区二区电影| 中文字幕爆乳julia女教师| 中文字幕精品无码一区二区三区| 色婷婷五月综合激情中文字幕| 亚洲乱码卡一卡二卡新区仙踪木木| 少妇精品视频无码专区| 亚洲v欧美v国产v在线观看| 国产超碰人人爽人人做| 中文日韩亚洲欧美制服| 国产亚洲一卡2卡3卡4卡网站 | 欧美特级婬片毛多的少妇| av制服丝袜白丝国产网站| 欧洲精品码一区二区三区免费看| 3d动漫精品一区二区三区 | 无码gogo大胆啪啪艺术| 人妻系列av无码专区| 亚洲欧美成αⅴ人在线观看| 国产又色又爽又黄的视频在线| 人与禽交videos欧美| 国产乱人伦偷精品视频免观看| 国色天香网www在线观看| 亚洲精品一卡2卡三卡4卡| 欧美人与性动交ccoo| 高清无码一区二区在线观看吞精| 99精品产国品一二三产区| 日韩精品无码熟人妻视频| 国产成人久久精品一区二区三区| 全部av―极品视觉盛宴| 亚洲乱码日产精品bd在线| 97se色综合一区二区二区| 国产强被迫伦姧在线观看无码| 五月丁香综合缴情六月小说| 久久精品免费一区二区三区| 夜夜高潮夜夜爽夜夜爱|