在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. RNF19A Antibody, FITC conjugated

RNF19A Antibody, FITC conjugated

  • 中文名稱：
    RNF19A兔多克隆抗體, FITC偶聯
  • 貨號：
    CSB-PA868327LC01HU
  • 規格：
    ￥880
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) RNF19A Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    RNF19A
  • 別名：
    AA032313 antibody; DKFZP566B1346 antibody; Dorfin antibody; Double ring finger protein antibody; Double ring-finger protein antibody; E3 ubiquitin-protein ligase RNF19A antibody; p38 antibody; p38 protein antibody; Ring finger protein 19 antibody; RING finger protein 19A antibody; Ring IBR ring domain containing protein Dorfin antibody; RN19A_HUMAN antibody; RNF19 antibody; RNF19A antibody; Ubce7ip2 antibody; UIP117 antibody; XYbp antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human E3 ubiquitin-protein ligase RNF19A protein (741-825AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    FITC
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式：
    Liquid
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates, such as SNCAIP or CASR. Specifically ubiquitinates pathogenic SOD1 variants, which leads to their proteasomal degradation and to neuronal protection.
  • 基因功能參考文獻：
    1. A more than 2-fold higher level of RNF19A mRNA in the blood of patients with prostate cancer than in healthy controls makes it an early diagnosis marker for this disease. PMID: 22493721
    2. Dorfin has a role in ubiquitylating mutant SOD1 proteins and targeting them for proteasomal degradation PMID: 12145308
    3. results suggest that synphilin-1 has an important role in the formation of aggregates and cytotoxicity in Parkinson disease and that Dorfin may be involved in the pathogenic process by ubiquitylation of synphilin-1 PMID: 12750386
    4. These results suggest that Dorfin plays a crucial role in the formation of ubiquitylated inclusions of alpha-synucleinopathy and amyotrophic lateral sclerosis. PMID: 12875980
    5. Reducing the accumulation of mutant superoxide dismutase 1 [SOD1] in the mitochondria may be a new therapeutic strategy for mutant SOD1-associated familial amyotrophic lateral sclerosis, and Dorfin may play a significant role in this PMID: 15030390
    6. Valosin-containing protein functionally regulates Dorfin through direct interaction PMID: 15456787
    7. Findings suggest that RNF19 has acquired a new promoter and alternative exons via continuous retrotransposition. PMID: 18721867

    顯示更多

    收起更多

  • 亞細胞定位：
    Membrane; Multi-pass membrane protein. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Present in the hyaline inclusion bodies specifically found in motor neurons from amyotrophic lateral sclerosis patients. Present in the Lewy bodies specifically found in neurons from Parkinson disease patients.
  • 蛋白家族：
    RBR family, RNF19 subfamily
  • 組織特異性：
    Widely expressed, with highest levels in heart. Ubiquitously expressed in the central nervous system.
  • 數據庫鏈接：

    HGNC: 13432

    OMIM: 607119

    KEGG: hsa:25897

    STRING: 9606.ENSP00000342667

    UniGene: Hs.292882



主站蜘蛛池模板： 日本韩国亚洲欧美在线| 国精产品一品二品国精品69xx| 亚洲18色成人网站www| 亚洲这里只有久热精品伊人| 国产一区二区三区精品av| 乱子伦农村xxxxbbb| 国产交换配乱婬视频| 俺去俺来也在线www色官网| 久久精品久久电影免费理论片| 午夜福利一区二区三区高清视频 | 亚洲精品国产品国语在线观看| 天堂官网在线资源网| 伊人色综合九久久天天蜜桃| 久久av无码精品人妻糸列| 蜜芽久久人人超碰爱香蕉| 国产精品有码无码av在线播放| 日本一道本高清一区二区| 午夜免费啪视频观看视频| 制服丝袜中文字幕在线| 成年轻人电影www无码| 日韩综合亚洲色在线影院| 天天综合色天天综合色hd| 国产亚洲精品久久久久蜜臀| 24小时日本在线www免费的| 日韩精品一区二区av在线| 国产伦精品一区二区三区免.费| а天堂中文在线官网| 久久精品国产亚洲一区二区| 亚洲欧洲免费三级网站| 五月丁香综合激情六月久久 | 少妇下蹲露大唇无遮挡| 亚洲色老汉av无码专区最| 亚洲国产中文在线视频| 40岁成熟女人牲交片20分钟| 午夜免费福利小电影| 国产精品久久久久久爽爽爽床戏| 日本二区三区欧美亚洲国产| 亚洲国产精品久久精品| 做爰高潮视频免费的看| 人人妻人人爽人人添夜夜欢视频| 在线成人www免费观看视频|