在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. RNF19A Antibody, FITC conjugated

RNF19A Antibody, FITC conjugated

  • 中文名稱：
    RNF19A兔多克隆抗體, FITC偶聯
  • 貨號：
    CSB-PA868327LC01HU
  • 規格：
    ￥880
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) RNF19A Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    RNF19A
  • 別名：
    AA032313 antibody; DKFZP566B1346 antibody; Dorfin antibody; Double ring finger protein antibody; Double ring-finger protein antibody; E3 ubiquitin-protein ligase RNF19A antibody; p38 antibody; p38 protein antibody; Ring finger protein 19 antibody; RING finger protein 19A antibody; Ring IBR ring domain containing protein Dorfin antibody; RN19A_HUMAN antibody; RNF19 antibody; RNF19A antibody; Ubce7ip2 antibody; UIP117 antibody; XYbp antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human E3 ubiquitin-protein ligase RNF19A protein (741-825AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    FITC
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式：
    Liquid
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates, such as SNCAIP or CASR. Specifically ubiquitinates pathogenic SOD1 variants, which leads to their proteasomal degradation and to neuronal protection.
  • 基因功能參考文獻：
    1. A more than 2-fold higher level of RNF19A mRNA in the blood of patients with prostate cancer than in healthy controls makes it an early diagnosis marker for this disease. PMID: 22493721
    2. Dorfin has a role in ubiquitylating mutant SOD1 proteins and targeting them for proteasomal degradation PMID: 12145308
    3. results suggest that synphilin-1 has an important role in the formation of aggregates and cytotoxicity in Parkinson disease and that Dorfin may be involved in the pathogenic process by ubiquitylation of synphilin-1 PMID: 12750386
    4. These results suggest that Dorfin plays a crucial role in the formation of ubiquitylated inclusions of alpha-synucleinopathy and amyotrophic lateral sclerosis. PMID: 12875980
    5. Reducing the accumulation of mutant superoxide dismutase 1 [SOD1] in the mitochondria may be a new therapeutic strategy for mutant SOD1-associated familial amyotrophic lateral sclerosis, and Dorfin may play a significant role in this PMID: 15030390
    6. Valosin-containing protein functionally regulates Dorfin through direct interaction PMID: 15456787
    7. Findings suggest that RNF19 has acquired a new promoter and alternative exons via continuous retrotransposition. PMID: 18721867

    顯示更多

    收起更多

  • 亞細胞定位：
    Membrane; Multi-pass membrane protein. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Present in the hyaline inclusion bodies specifically found in motor neurons from amyotrophic lateral sclerosis patients. Present in the Lewy bodies specifically found in neurons from Parkinson disease patients.
  • 蛋白家族：
    RBR family, RNF19 subfamily
  • 組織特異性：
    Widely expressed, with highest levels in heart. Ubiquitously expressed in the central nervous system.
  • 數據庫鏈接：

    HGNC: 13432

    OMIM: 607119

    KEGG: hsa:25897

    STRING: 9606.ENSP00000342667

    UniGene: Hs.292882



主站蜘蛛池模板： 玩弄丰满少妇xxxxx性多毛| 人人婷婷人人澡人人爽| 深夜爽爽动态图无遮无挡| 毛片免费视频在线观看| √天堂资源地址中文在线| 妖精色av无码国产在线看| 精产国品一二三产品麻豆| 国产无遮挡又黄又爽在线观看| 国产精品ⅴ无码大片在线看| 成人高潮视频在线观看| 亚洲中文字幕第一页在线| 国产亚洲精品久久yy50| 日产一区日产2区| 丁香婷婷综合久久来来去| 国产精华av午夜在线观看| 亚洲熟妇丰满多毛xxxx| 无码专区男人本色| 亚洲性夜夜综合久久7777| 亚洲欧美中文日韩v在线97| 虎白女粉嫩尤物福利视频| 少妇做爰免费视看片| 精品午夜福利在线视在亚洲 | 国产亚洲久久久久久久| 人妻在线日韩免费视频| 国产又猛又黄又爽| 久久精品人成免费| 波多野结衣办公室33分钟| 欧美亚洲色综久久精品国产| 女人被狂爆到高潮免费视频 | 精品国精品国产自在久国产应用| 丰满少妇作爱视频免费观看| 日本亚洲国产一区二区三区| 97丨九色丨国产人妻熟女| ww国产内射精品后入国产| 日本在线看片免费人成视频| 久久婷婷五月综合色奶水99啪| 久久久久久亚洲精品| 亚洲精品v天堂中文字幕| 亚洲日韩中文字幕久热| 日日躁夜夜躁狠狠久久av| 国产剧情麻豆女教师在线观看|