在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. RNF19A Antibody, FITC conjugated

RNF19A Antibody, FITC conjugated

  • 中文名稱：
    RNF19A兔多克隆抗體, FITC偶聯
  • 貨號：
    CSB-PA868327LC01HU
  • 規格：
    ￥880
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) RNF19A Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    RNF19A
  • 別名：
    AA032313 antibody; DKFZP566B1346 antibody; Dorfin antibody; Double ring finger protein antibody; Double ring-finger protein antibody; E3 ubiquitin-protein ligase RNF19A antibody; p38 antibody; p38 protein antibody; Ring finger protein 19 antibody; RING finger protein 19A antibody; Ring IBR ring domain containing protein Dorfin antibody; RN19A_HUMAN antibody; RNF19 antibody; RNF19A antibody; Ubce7ip2 antibody; UIP117 antibody; XYbp antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human E3 ubiquitin-protein ligase RNF19A protein (741-825AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    FITC
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式：
    Liquid
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates, such as SNCAIP or CASR. Specifically ubiquitinates pathogenic SOD1 variants, which leads to their proteasomal degradation and to neuronal protection.
  • 基因功能參考文獻：
    1. A more than 2-fold higher level of RNF19A mRNA in the blood of patients with prostate cancer than in healthy controls makes it an early diagnosis marker for this disease. PMID: 22493721
    2. Dorfin has a role in ubiquitylating mutant SOD1 proteins and targeting them for proteasomal degradation PMID: 12145308
    3. results suggest that synphilin-1 has an important role in the formation of aggregates and cytotoxicity in Parkinson disease and that Dorfin may be involved in the pathogenic process by ubiquitylation of synphilin-1 PMID: 12750386
    4. These results suggest that Dorfin plays a crucial role in the formation of ubiquitylated inclusions of alpha-synucleinopathy and amyotrophic lateral sclerosis. PMID: 12875980
    5. Reducing the accumulation of mutant superoxide dismutase 1 [SOD1] in the mitochondria may be a new therapeutic strategy for mutant SOD1-associated familial amyotrophic lateral sclerosis, and Dorfin may play a significant role in this PMID: 15030390
    6. Valosin-containing protein functionally regulates Dorfin through direct interaction PMID: 15456787
    7. Findings suggest that RNF19 has acquired a new promoter and alternative exons via continuous retrotransposition. PMID: 18721867

    顯示更多

    收起更多

  • 亞細胞定位：
    Membrane; Multi-pass membrane protein. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Present in the hyaline inclusion bodies specifically found in motor neurons from amyotrophic lateral sclerosis patients. Present in the Lewy bodies specifically found in neurons from Parkinson disease patients.
  • 蛋白家族：
    RBR family, RNF19 subfamily
  • 組織特異性：
    Widely expressed, with highest levels in heart. Ubiquitously expressed in the central nervous system.
  • 數據庫鏈接：

    HGNC: 13432

    OMIM: 607119

    KEGG: hsa:25897

    STRING: 9606.ENSP00000342667

    UniGene: Hs.292882



主站蜘蛛池模板： 男女做爰无遮挡性视频 | 国精产品一品二品国精在线观看 | 久久青青草原国产精品最新片| 欧美人妻久久精品| 亚洲午夜成人av电影| 中文字幕人成无码人妻| 18禁勿入网站入口永久| 久久久精品人妻一区二区三区gv | 国产白嫩美女在线观看| 成av人电影在线观看| 亚洲国产成人久久综合同性| 亚洲色欲色欲www在线看| www一区二区www免费| 欧美黑人粗大xxxxbbbb| 久久天天躁夜夜躁狠狠85| 国产一起色一起爱| 久久这里只有精品18| 98视频精品全部国产| 真人一进一出120秒试看| 欧美成人一区二区三区在线观看| 久久国产成人精品国产成人亚洲| 免费无码成人av在线播| 国产美女精品视频线免费播放软件| 人妻少妇精品中文字幕av蜜桃| 亚洲gv猛男gv无码男同 | 国产人成无码视频在线| 奇米777四色成人影视| 国产精品久久久久aaaa| 欧美一区二区日韩国产| 亚 洲 成 人 网站在线观看| 国产在线拍揄自揄拍免费下载| 久久久久久人妻无码| 国产成人综合色视频精品| 香草乱码一二三四区别| 色婷婷综合久久久中文字幕| 夜夜爱夜夜做夜夜爽| 国产精品禁忌a片特黄a片| 免费拍拍拍网站| 国产精品成人久久久久久久| 国产人成高清在线视频99最全资源| 97爱亚洲综合成人|