在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. RNF19A Antibody, Biotin conjugated

RNF19A Antibody, Biotin conjugated

  • 中文名稱：
    RNF19A兔多克隆抗體, Biotin偶聯
  • 貨號：
    CSB-PA868327LD01HU
  • 規格：
    ￥880
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) RNF19A Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    RNF19A
  • 別名：
    AA032313 antibody; DKFZP566B1346 antibody; Dorfin antibody; Double ring finger protein antibody; Double ring-finger protein antibody; E3 ubiquitin-protein ligase RNF19A antibody; p38 antibody; p38 protein antibody; Ring finger protein 19 antibody; RING finger protein 19A antibody; Ring IBR ring domain containing protein Dorfin antibody; RN19A_HUMAN antibody; RNF19 antibody; RNF19A antibody; Ubce7ip2 antibody; UIP117 antibody; XYbp antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human E3 ubiquitin-protein ligase RNF19A protein (741-825AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Biotin
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates, such as SNCAIP or CASR. Specifically ubiquitinates pathogenic SOD1 variants, which leads to their proteasomal degradation and to neuronal protection.
  • 基因功能參考文獻：
    1. A more than 2-fold higher level of RNF19A mRNA in the blood of patients with prostate cancer than in healthy controls makes it an early diagnosis marker for this disease. PMID: 22493721
    2. Dorfin has a role in ubiquitylating mutant SOD1 proteins and targeting them for proteasomal degradation PMID: 12145308
    3. results suggest that synphilin-1 has an important role in the formation of aggregates and cytotoxicity in Parkinson disease and that Dorfin may be involved in the pathogenic process by ubiquitylation of synphilin-1 PMID: 12750386
    4. These results suggest that Dorfin plays a crucial role in the formation of ubiquitylated inclusions of alpha-synucleinopathy and amyotrophic lateral sclerosis. PMID: 12875980
    5. Reducing the accumulation of mutant superoxide dismutase 1 [SOD1] in the mitochondria may be a new therapeutic strategy for mutant SOD1-associated familial amyotrophic lateral sclerosis, and Dorfin may play a significant role in this PMID: 15030390
    6. Valosin-containing protein functionally regulates Dorfin through direct interaction PMID: 15456787
    7. Findings suggest that RNF19 has acquired a new promoter and alternative exons via continuous retrotransposition. PMID: 18721867

    顯示更多

    收起更多

  • 亞細胞定位：
    Membrane; Multi-pass membrane protein. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Present in the hyaline inclusion bodies specifically found in motor neurons from amyotrophic lateral sclerosis patients. Present in the Lewy bodies specifically found in neurons from Parkinson disease patients.
  • 蛋白家族：
    RBR family, RNF19 subfamily
  • 組織特異性：
    Widely expressed, with highest levels in heart. Ubiquitously expressed in the central nervous system.
  • 數據庫鏈接：

    HGNC: 13432

    OMIM: 607119

    KEGG: hsa:25897

    STRING: 9606.ENSP00000342667

    UniGene: Hs.292882



主站蜘蛛池模板： 亚洲桃色天堂网| 高清无码一区二区在线观看吞精| 日本又色又爽又黄的视频免 | 无码人妻av一区二区三区蜜臀| 国产极品美女高潮抽搐免费网站| 亚洲另类春色校园小说| 国产偷人妻精品一区二区在线| 免费人成在线视频无码| 亚洲精品国产高清在线观看| 亚洲成av人片一区二区三区| 中文乱码字慕人妻熟女人妻| 国产真实乱对白精彩| 丁香五月缴情在线| 亚洲综合天堂一区二区三区| 美女网站免费福利视频| 欧美顶级少妇做爰hd| 一个人在线观看免费中文www | 亚洲香蕉成人av网站在线观看| 狠狠久久噜噜熟女| 中文字幕 欧美精品 第1页| 最新亚洲人成无码网站| 丰满人妻熟妇乱又伦精品视| 欧美老妇牲交videos| 日产精品卡2卡三卡乱码网站| 性欧美老妇另类xxxx| 男受被做哭激烈娇喘gv视频 | 欧美性欧美巨大黑白大战| 欧美影视精品久久| 麻豆视传媒在线观看| b站永久免费看片大全| 无码国产一区二区三区四区| 欧美白丰满老太aaa片| 国内精品自在自线| 失禁潮痉挛潮喷av在线无码| 国产99视频精品免费视频76| 亚洲午夜福利在线视频| 成人免费xxxxx在线观看| 欧美亚洲日本国产综合在线| av无码午夜福利一区二区三区| 国产丝袜视频一区二区三区| 成人免费的视频|