在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. RNF125 Antibody, HRP conjugated

RNF125 Antibody, HRP conjugated

  • 中文名稱：
    RNF125兔多克隆抗體, HRP偶聯
  • 貨號：
    CSB-PA836205LB01HU
  • 規格：
    ￥880
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) RNF125 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    RNF125
  • 別名：
    RNF125 antibody; E3 ubiquitin-protein ligase RNF125 antibody; EC 2.3.2.27 antibody; RING finger protein 125 antibody; T-cell RING activation protein 1 antibody; TRAC-1 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human E3 ubiquitin-protein ligase RNF125 protein (143-231AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    HRP
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins, such as DDX58/RIG-I, MAVS/IPS1, IFIH1/MDA5, JAK1 and p53/TP53. Acts as a negative regulator of type I interferon production by mediating ubiquitination of DDX58/RIG-I at 'Lys-181', leading to DDX58/RIG-I degradation. Mediates ubiquitination and subsequent degradation of p53/TP53. Mediates ubiquitination and subsequent degradation of JAK1. Acts as a positive regulator of T-cell activation.
  • 基因功能參考文獻：
    1. this study shows that RNF125 activates Interleukin-36 receptor signaling and contributes to its turnover PMID: 29176319
    2. for the ubiquitin ligase RNF125 that, in addition to the RING domain, a C2HC Zn finger (ZnF) is crucial for activity. PMID: 27411375
    3. high RNF125 expression is related with aggressive characteristics and unfavorable prognosis of GBC patients; RNF125 promotes the invasion and metastasis of human GBCs via activating the TGF-beta1-SMAD3-ID1 signaling pathway. PMID: 28611292
    4. study identifies new gene-type zinc finger protein 125 (RNF125) as a negative regulator of TRIM14 in the innate antiviral immune response PMID: 28476934
    5. we identified the downregulation of the ubiquitin ligase RNF125 in BRAFi-resistant melanomas PMID: 26027934
    6. Results indicate that the nucleotide sequence in the 3' untranslated region (3' UTR) of ring finger protein 125 (RNF125) is a potential microRNA miR-15b targeting site. PMID: 26202983
    7. studies of the RNF125 pathway point to upregulation of RIG-I-IPS1-MDA5 and/or disruption of the PI3K-AKT and interferon signaling pathways as the putative final effectors PMID: 25196541
    8. In controls, RNF125 is the highest expressed gene, whereas in HIV infection progressors, RIG-I is either the highest expressed gene or is expressed similarly to RNF125 and TRIM25. PMID: 24131985
    9. study reports human bocavirus VP2 modulates IFN pathway by targeting the ring finger protein 125, a negative regulator of type I IFN signaling, which conjugates Lys(48)-linked ubiquitination to retinoic acid-inducible gene-I and leads to the proteasome-dependent degradation of RIG-I PMID: 23772026
    10. These results suggest that RNF125/TRAC-1 could function to recruit host factor(s) controlling HIV-1 transcription to the ubiquitin-proteasome pathway. PMID: 17643463
    11. TRAC-1 associates with membranes and is excluded from the nucleus through myristoylation PMID: 17990982

    顯示更多

    收起更多

  • 相關疾?。?/div>
    Tenorio syndrome (TNORS)
  • 亞細胞定位：
    Golgi apparatus membrane; Lipid-anchor.
  • 組織特異性：
    Predominantly expressed in lymphoid tissues, including bone marrow, spleen and thymus. Also weakly expressed in other tissues. Predominant in the CD4(+) and CD8(+) T-cells, suggesting that it is preferentially confined to T-cells.
  • 數據庫鏈接：

    HGNC: 21150

    OMIM: 610432

    KEGG: hsa:54941

    STRING: 9606.ENSP00000217740

    UniGene: Hs.633703



主站蜘蛛池模板： 夜晚成人18禁区导航网站| 国内精品久久久久影院薰衣草| 亚洲色无码专线精品观看| 天堂网在线www资源| 精品国产一区二区三区四区| 久久久久无码国产精品不卡| 人人鲁人人莫人人爱精品| 国产超碰人人做人人爽av动图| 国产成人综合久久精品| 国产卡一卡二卡三无线乱码新区| 国产a√精品区二区三区四区| 国产欧美日韩综合在线成| 午夜色大片在线观看| 国产口爆吞精在线视频2020版| 日韩乱码人妻无码系列中文字幕 | 亚洲欧美第一成人网站7777| 亚洲免费观看在线视频| 人妻精品久久久久中文字幕| 成年片色大黄全免费网站久久| 国产午夜高潮熟女精品av软件| 激情综合色综合啪啪五月丁香 | 国产超级va在线观看视频| 欧美亚洲综合在线一区| 亚洲深深色噜噜狠狠爱网站 | 大肉大捧一进一出好爽app| 国产高清女同学巨大乳在线观看| 99久久国产综合精品五月天喷水| 欧美成人免费一区二区| 在线观看免费网页欧美成| 日本老熟妇乱子伦视频| 人妻丰满熟妇av无码区| 老太脱裤子让老头玩xxxxx| 国产精品高潮呻吟av久久小说| 免费观看日本污污ww网站| 搡老岳熟女国产熟妇| 强被迫伦姧惨叫人妻系列| 中国老熟妇自拍hd发布| 人妻去按摩店被黑人按中出| 亚洲精品亚洲人成在线观看| 精品熟女少妇av久久免费软件 | 亚洲国产aⅴ综合网|