在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

RNF125 Antibody, FITC conjugated

  • 中文名稱:
    RNF125兔多克隆抗體, FITC偶聯
  • 貨號:
    CSB-PA836205LC01HU
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) RNF125 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    RNF125
  • 別名:
    RNF125 antibody; E3 ubiquitin-protein ligase RNF125 antibody; EC 2.3.2.27 antibody; RING finger protein 125 antibody; T-cell RING activation protein 1 antibody; TRAC-1 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human E3 ubiquitin-protein ligase RNF125 protein (143-231AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    FITC
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式:
    Liquid
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins, such as DDX58/RIG-I, MAVS/IPS1, IFIH1/MDA5, JAK1 and p53/TP53. Acts as a negative regulator of type I interferon production by mediating ubiquitination of DDX58/RIG-I at 'Lys-181', leading to DDX58/RIG-I degradation. Mediates ubiquitination and subsequent degradation of p53/TP53. Mediates ubiquitination and subsequent degradation of JAK1. Acts as a positive regulator of T-cell activation.
  • 基因功能參考文獻:
    1. this study shows that RNF125 activates Interleukin-36 receptor signaling and contributes to its turnover PMID: 29176319
    2. for the ubiquitin ligase RNF125 that, in addition to the RING domain, a C2HC Zn finger (ZnF) is crucial for activity. PMID: 27411375
    3. high RNF125 expression is related with aggressive characteristics and unfavorable prognosis of GBC patients; RNF125 promotes the invasion and metastasis of human GBCs via activating the TGF-beta1-SMAD3-ID1 signaling pathway. PMID: 28611292
    4. study identifies new gene-type zinc finger protein 125 (RNF125) as a negative regulator of TRIM14 in the innate antiviral immune response PMID: 28476934
    5. we identified the downregulation of the ubiquitin ligase RNF125 in BRAFi-resistant melanomas PMID: 26027934
    6. Results indicate that the nucleotide sequence in the 3' untranslated region (3' UTR) of ring finger protein 125 (RNF125) is a potential microRNA miR-15b targeting site. PMID: 26202983
    7. studies of the RNF125 pathway point to upregulation of RIG-I-IPS1-MDA5 and/or disruption of the PI3K-AKT and interferon signaling pathways as the putative final effectors PMID: 25196541
    8. In controls, RNF125 is the highest expressed gene, whereas in HIV infection progressors, RIG-I is either the highest expressed gene or is expressed similarly to RNF125 and TRIM25. PMID: 24131985
    9. study reports human bocavirus VP2 modulates IFN pathway by targeting the ring finger protein 125, a negative regulator of type I IFN signaling, which conjugates Lys(48)-linked ubiquitination to retinoic acid-inducible gene-I and leads to the proteasome-dependent degradation of RIG-I PMID: 23772026
    10. These results suggest that RNF125/TRAC-1 could function to recruit host factor(s) controlling HIV-1 transcription to the ubiquitin-proteasome pathway. PMID: 17643463
    11. TRAC-1 associates with membranes and is excluded from the nucleus through myristoylation PMID: 17990982

    顯示更多

    收起更多

  • 相關疾病:
    Tenorio syndrome (TNORS)
  • 亞細胞定位:
    Golgi apparatus membrane; Lipid-anchor.
  • 組織特異性:
    Predominantly expressed in lymphoid tissues, including bone marrow, spleen and thymus. Also weakly expressed in other tissues. Predominant in the CD4(+) and CD8(+) T-cells, suggesting that it is preferentially confined to T-cells.
  • 數據庫鏈接:

    HGNC: 21150

    OMIM: 610432

    KEGG: hsa:54941

    STRING: 9606.ENSP00000217740

    UniGene: Hs.633703



主站蜘蛛池模板: 开心色怡人综合网站| 无码h肉在线观看免费一区| 男女啪啪无遮挡免费网站| 无码精品一区二区三区免费视频| 国产成人a∨激情视频厨房| 推油少妇久久99久久99久久| 国产精品成人免费999| 亚洲日韩av片在线观看| 亚洲国产精品无码久久久蜜芽| 国产乱人伦真实精品视频| 丁香五香天堂网| 中国xxxx做受视频| 国产又色又爽又黄的视频在线观看| 久久亚洲熟女cc98cm| 免费无码鲁丝片一区二区| 国产综合色在线视频区| 国产人妻精品区一区二区三区 | 亚洲精品久久午夜无码一区二区| 无码av不卡免费播放| 五月综合激情婷婷六月色窝| 国产情侣久久久久aⅴ免费| 国产成人福利美女观看视频| 亚洲色大成网站www永久在线观看| 漂亮人妻被中出中文字幕| 久久精品国产99国产精品导航| 粗壮挺进人妻水蜜桃成熟漫画| 国语自产拍无码精品视频在线| 日日碰狠狠躁久久躁婷婷| 国产精品久久久久av| 国产成人无码精品一区二区三区| 上海少妇高潮狂叫喷水了| 国产一区二区内射最近更新| 国产一区二区三区| 久久精品成人免费观看| 久久97精品久久久久久久不卡| 国产av成人一区二区三区| 欧美不卡无线在线一二三区观| 最近中文字幕mv在线视频看| 国产精品久久久| 精品一卡二卡三卡| 亚洲 一区二区 在线|