在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

RHOJ Antibody

  • 中文名稱:
    RHOJ兔多克隆抗體
  • 貨號:
    CSB-PA872495LA01HU
  • 規格:
    ¥440
  • 圖片:
    • Immunohistochemistry of paraffin-embedded human liver cancer using CSB-PA872495LA01HU at dilution of 1:100
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) RHOJ Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 別名:
    ARHJ antibody; Ras homolog family member J antibody; Ras homolog gene family member J antibody; RAS like family 7 member B antibody; Ras like protein family member 7B antibody; Ras-like protein family member 7B antibody; RASL 7B antibody; RASL7B antibody; Rho related GTP binding protein RhoJ antibody; Rho-related GTP-binding protein RhoJ antibody; RHOI antibody; Rhoj antibody; RHOJ_HUMAN antibody; Tc10 like GTP binding protein TCL antibody; TC10 like Rho GTPase antibody; Tc10-like GTP-binding protein antibody; TC10B antibody; TCL antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Rho-related GTP-binding protein RhoJ protein (1-211AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated

    本頁面中的產品,RHOJ Antibody (CSB-PA872495LA01HU),的標記方式是Non-conjugated。對于RHOJ Antibody,我們還提供其他標記。見下表:

    可提供標記
    標記方式 貨號 產品名稱 應用
    HRP CSB-PA872495LB01HU RHOJ Antibody, HRP conjugated ELISA
    FITC CSB-PA872495LC01HU RHOJ Antibody, FITC conjugated
    Biotin CSB-PA872495LD01HU RHOJ Antibody, Biotin conjugated ELISA
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA, IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Plasma membrane-associated small GTPase specifically involved in angiogenesis. Required for endothelial cell migration during vascular development via its interaction with GLUL. Elicits the formation of F-actin-rich structures, thereby regulating endothelial cell migration.
  • 基因功能參考文獻:
    1. Short-term treatment of nascent melanoma tumors with PAK inhibitors that block RhoJ signaling halts the growth of BRAF mutant melanoma tumors in vivo and induces apoptosis in melanoma cells in vitro via a BAD-dependent mechanism. As up to 50% of BRAF mutant human melanomas express high levels of RhoJ, these studies nominate the RhoJ-BAD signaling network as a therapeutic vulnerability for fledgling BRAF mutant human tumor PMID: 28753606
    2. These results identify amino acids within the N terminus and a loop region distal to the nucleotide binding pocket of TCL capable of allosterically regulating nucleotide exchange and thus influence membrane association of the protein. PMID: 27660391
    3. FMNL3 interacts with Cdc42 and RhoJ, two Rho family GTPases known to be required for lumen formation. FMNL3 and RhoJ are concentrated at the early apical surface, or AMIS, and regulate the formation of radiating actin cables from this site. PMID: 26299518
    4. RhoJ-knockout mice showed reduced tumour growth and diminished tumour vessel density, identifying a role for RhoJ in mediating tumour angiogenesis. Studies give insight into the molecular function of RhoJ in regulating cell motility. PMID: 24928894
    5. These results identify RhoJ blockade as a selective and effective therapeutic strategy for targeting tumor vasculature with minimal side effects. PMID: 24434213
    6. These observations identify RHOJ as a melanoma linchpin determinant that regulates both actin cytoskeletal dynamics and chemoresistance by activating PAK1. PMID: 23253891
    7. Arhgef15 acts as an endothelial cell-specific GEF to mediate VEGF-induced Cdc42 activation and potentiate RhoJ inactivation, thereby promoting actin polymerization and cell motility. PMID: 23029280
    8. we identified RhoJ and its effector PAK1, as key modulators of melanoma cell sensitivity to DNA damage PMID: 22971344
    9. Our study supports a novel role for the Rho family member RhoJ in ednothelial cell morphogenesis and in particular in lumen formation PMID: 21628409
    10. RhoJ is endothelial-expressed in vivo, activated by vascular endothelial growth factor, localizes to focal adhesions, regulates endothelial cell migration and tube formation, and modulates actomyosin contractility and focal adhesion numbers. PMID: 21148427
    11. TCL is essential for clathrin-dependent endocytosed receptors to enter the early/sorting endosomes PMID: 12960428

    顯示更多

    收起更多

  • 亞細胞定位:
    Cell membrane; Lipid-anchor; Cytoplasmic side.
  • 蛋白家族:
    Small GTPase superfamily, Rho family
  • 組織特異性:
    Specifically expressed in endothelial cells in different tissues, such as brain, heart, lung and liver.
  • 數據庫鏈接:

    HGNC: 688

    OMIM: 607653

    KEGG: hsa:57381

    STRING: 9606.ENSP00000316729

    UniGene: Hs.656339



主站蜘蛛池模板: 欧美肉大捧一进一出免费视频| 免费大香伊蕉在人线国产卡| 又大又紧又粉嫩18p少妇| a一区二区三区乱码在线 | 欧洲| 精品无码一区二区三区电影| 久久三级中文欧大战字幕| 久久国产人妻一区二区| 人人妻人人澡人人爽久久av| 99久久精品无码一区二区三区| 久久久久久久久免费看无码 | 插插插精品亚洲一区| 麻豆视传媒在线观看| 性人久久久久| 饥渴少妇做私密保健视频| 白嫩少妇bbw撒尿视频| 极品少妇的粉嫩小泬视频| 久久国产精品一国产精品| 女学生14毛片视频片二毛| 性饥渴少妇av无码毛片| 日本熟妇人妻xxxx| 国产免费一区二区视频| 2020年国产精品| 美女网站免费福利视频| 免费体验区试看120秒| 国产成人无码18禁午夜福利网址| 成年轻人网站色直接看| 国产精品第12页| 亚洲高清无在码在线电影不卡| 亚洲人成手机电影网站| 国产成人a区在线观看视频| 中文字幕乱码在线播放| 无套熟女av呻吟在线观看| 国产精品毛片更新无码| 人妻av中文系列| 国产精品igao视频网网址| 亚洲国产成人精品无码区宅男| 好硬好湿好爽再深一点动态图视频| 野外做受又硬又粗又大视频| 久久亚洲精品情侣| 香港三级日本三级韩级人妇| 丰满人妻妇伦又伦精品国产|