在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

RHOJ Antibody, FITC conjugated

  • 中文名稱:
    RHOJ兔多克隆抗體, FITC偶聯(lián)
  • 貨號:
    CSB-PA872495LC01HU
  • 規(guī)格:
    ¥880
  • 其他:

產(chǎn)品詳情

  • 產(chǎn)品名稱:
    Rabbit anti-Homo sapiens (Human) RHOJ Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 別名:
    ARHJ antibody; Ras homolog family member J antibody; Ras homolog gene family member J antibody; RAS like family 7 member B antibody; Ras like protein family member 7B antibody; Ras-like protein family member 7B antibody; RASL 7B antibody; RASL7B antibody; Rho related GTP binding protein RhoJ antibody; Rho-related GTP-binding protein RhoJ antibody; RHOI antibody; Rhoj antibody; RHOJ_HUMAN antibody; Tc10 like GTP binding protein TCL antibody; TC10 like Rho GTPase antibody; Tc10-like GTP-binding protein antibody; TC10B antibody; TCL antibody
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human
  • 免疫原:
    Recombinant Human Rho-related GTP-binding protein RhoJ protein (1-211AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標(biāo)記方式:
    FITC
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式:
    Liquid
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能:
    Plasma membrane-associated small GTPase specifically involved in angiogenesis. Required for endothelial cell migration during vascular development via its interaction with GLUL. Elicits the formation of F-actin-rich structures, thereby regulating endothelial cell migration.
  • 基因功能參考文獻:
    1. Short-term treatment of nascent melanoma tumors with PAK inhibitors that block RhoJ signaling halts the growth of BRAF mutant melanoma tumors in vivo and induces apoptosis in melanoma cells in vitro via a BAD-dependent mechanism. As up to 50% of BRAF mutant human melanomas express high levels of RhoJ, these studies nominate the RhoJ-BAD signaling network as a therapeutic vulnerability for fledgling BRAF mutant human tumor PMID: 28753606
    2. These results identify amino acids within the N terminus and a loop region distal to the nucleotide binding pocket of TCL capable of allosterically regulating nucleotide exchange and thus influence membrane association of the protein. PMID: 27660391
    3. FMNL3 interacts with Cdc42 and RhoJ, two Rho family GTPases known to be required for lumen formation. FMNL3 and RhoJ are concentrated at the early apical surface, or AMIS, and regulate the formation of radiating actin cables from this site. PMID: 26299518
    4. RhoJ-knockout mice showed reduced tumour growth and diminished tumour vessel density, identifying a role for RhoJ in mediating tumour angiogenesis. Studies give insight into the molecular function of RhoJ in regulating cell motility. PMID: 24928894
    5. These results identify RhoJ blockade as a selective and effective therapeutic strategy for targeting tumor vasculature with minimal side effects. PMID: 24434213
    6. These observations identify RHOJ as a melanoma linchpin determinant that regulates both actin cytoskeletal dynamics and chemoresistance by activating PAK1. PMID: 23253891
    7. Arhgef15 acts as an endothelial cell-specific GEF to mediate VEGF-induced Cdc42 activation and potentiate RhoJ inactivation, thereby promoting actin polymerization and cell motility. PMID: 23029280
    8. we identified RhoJ and its effector PAK1, as key modulators of melanoma cell sensitivity to DNA damage PMID: 22971344
    9. Our study supports a novel role for the Rho family member RhoJ in ednothelial cell morphogenesis and in particular in lumen formation PMID: 21628409
    10. RhoJ is endothelial-expressed in vivo, activated by vascular endothelial growth factor, localizes to focal adhesions, regulates endothelial cell migration and tube formation, and modulates actomyosin contractility and focal adhesion numbers. PMID: 21148427
    11. TCL is essential for clathrin-dependent endocytosed receptors to enter the early/sorting endosomes PMID: 12960428

    顯示更多

    收起更多

  • 亞細胞定位:
    Cell membrane; Lipid-anchor; Cytoplasmic side.
  • 蛋白家族:
    Small GTPase superfamily, Rho family
  • 組織特異性:
    Specifically expressed in endothelial cells in different tissues, such as brain, heart, lung and liver.
  • 數(shù)據(jù)庫鏈接:

    HGNC: 688

    OMIM: 607653

    KEGG: hsa:57381

    STRING: 9606.ENSP00000316729

    UniGene: Hs.656339



主站蜘蛛池模板: 人人爽人人模人人人爽人人爱| 亚洲精品国产a久久久久久| 国产成人精品男人的天堂| 波多野结衣网站| 专干熟肥老妇人视频在线看| 国产成人综合亚洲看片| 少妇爆乳无码专区| 色欲久久久天天天综合网精品| 色噜噜亚洲男人的天堂| 在线看午夜福利片国产| 手机福利视频| 日韩乱码人妻无码中文字幕| 手机看黄av免费网址| 欧美两根一起进3p在线观看| 精品无码专区毛片| 久久久亚洲欧洲日产国产成人无码 | 少妇人妻偷人激情视频| 国内露脸中年夫妇交换| 精品国产经典三级在线看| 高清乱码一区二区三区| 制服 丝袜 人妻 专区一本| 又黄又爽吃奶视频在线观看| 99热亚洲色精品国产88| 亚洲第一a在线观看网站| 啦啦啦www播放日本观看 | 蜜臀av无码精品人妻色欲| 中文在线а√在线| 国产精品jk白丝在线播放| 国产成人小说视频在线观看| 日日碰狠狠躁久久躁婷婷| 国产亚洲精品久久久久久久软件| 无码一区二区三区老色鬼 | 欧美三级a做爰在线观看| 国产人成视频在线视频| 夜夜春亚洲嫩草影院| 囯产精品一区二区三区线| 国产午夜视频在线观看| 亚洲狠狠色成人综合网| 999国内精品永久免费观看| 国产女人18毛片水真多1| 成人做爰100部片免费下载|