在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

RHCG Antibody

  • 中文名稱:
    RHCG兔多克隆抗體
  • 貨號:
    CSB-PA442653
  • 規(guī)格:
    ¥1100
  • 圖片:
    • The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA442653(RHCG Antibody) at dilution 1/35, on the right is treated with synthetic peptide. (Original magnification: ×200)
    • Gel: 8%SDS-PAGE,Lysate: 40 μg,Lane 1-2: Human placenta tissue, Human breast infiltrative duct tissue,Primary antibody: CSB-PA442653(RHCG Antibody) at dilution 1/550 dilution,Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution,Exposure time: 5 minutes
  • 其他:

產(chǎn)品詳情

  • Uniprot No.:
  • 基因名:
    RHCG
  • 別名:
    Ammonium transporter Rh type C antibody; C15orf6 antibody; CDRC2 antibody; chromosome 15 open reading frame 6 antibody; PDRC2 antibody; Rh family type C glycoprotein antibody; Rh glycoprotein kidney antibody; Rh type C glycoprotein antibody; rhcg antibody; RHCG_HUMAN antibody; Rhesus blood group family type C glycoprotein antibody; Rhesus blood group; C glycoprotein antibody; RHGK antibody; SLC42A3 antibody; Tumor-related protein DRC2 antibody
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human
  • 免疫原:
    Synthetic peptide of Human RHCG
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標(biāo)記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen affinity purification
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產(chǎn)品提供形式:
    Liquid
  • 應(yīng)用范圍:
    ELISA,WB,IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    ELISA 1:1000-1:2000
    WB 1:200-1:1000
    IHC 1:25-1:100
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能:
    Functions as an electroneutral and bidirectional ammonium transporter. May regulate transepithelial ammonia secretion.
  • 基因功能參考文獻(xiàn):
    1. RhCG and H+ATPases are located within the same cellular protein complex in the kidney and this interaction is required for maximal urinary acidification by H+-ATPases, a prerequisite for efficient NH3 secretion and urine excretion of NH4+. PMID: 29054531
    2. RHCG was down-regulated in cervical cancers compared to that in normal cervical tissues, and further decreased in cervical cancer cell lines. Functionally, RHCG overexpression reduced cervical cancer cell proliferation and migration, as evidenced by the decreased transforming growth factor (TGF)-beta1, matrix metalloproteinase (MMP)-2 and MMP-9 expressions in cancer cells. PMID: 29852177
    3. The results support the notion that RHCG is a novel tumor suppressor gene that plays an important role in the development and progression of ESCC. PMID: 29290801
    4. The molecular mechanism of NH4(+) recruitment and NH3 transport by RHCG is described. PMID: 26190573
    5. Rh B Glycoprotein (Rhbg) and Rh C Glycoprotein (Rhcg) are identified as ammonia transporters. They are expressed in specific cell populations and membrane domains in distal renal epithelial cells, where they facilitate ammonia secretion. PMID: 24647713
    6. RhAG, RhBG and RhCG-exhibit significant permeability to NH3 and show for the first time that RhBG and RhCG can conduct CO2. PMID: 24077989
    7. Amt and Rh proteins are not functionally equivalent and that permeation takes place according to two distinct mechanisms. PMID: 24021113
    8. X-ray crystallographic structure of human RhCG, determined at 2.1 A resolution, reveals the mechanism of ammonia transport. PMID: 20457942
    9. major finding of this study is that RhCG protein is active as an NH(3) channel and that this function does not require any protein partner PMID: 20126667
    10. RhBG and RhCG facilitate ammonium movement across the plasma membrane; these results favor the hypothesis that these Rh glycoproteins, together with their homolog RhAG, constitute a family of NH3 channels in mammalian cells. PMID: 15929723
    11. RhCG expression enhanced the ammonium-induced initial alkalinization (related to NH3 influx)& secondary acidification (related to NH4+ influx). Sub-millimolar NH4+ concentrations induced inward currents in voltage-clamped RhCG-expressing cells. PMID: 16564724
    12. Review. Mutations at positions F74, V137 and F235 resulted in a severe reduction of NH3 transport. PMID: 16580862
    13. This study concludes that under normal conditions, RhCG is the major putative ammonia transporter expressed in the human kidney and RhBG is not expressed at detectable levels. PMID: 19357182
    14. Rhbg and Rhcg may contribute to bronchial epithelial cell ammonia metabolism and suggest that they do not contribute to pulmonary carbon dioxide transport. PMID: 19429772

    顯示更多

    收起更多

  • 亞細(xì)胞定位:
    Apical cell membrane; Multi-pass membrane protein.
  • 蛋白家族:
    Ammonium transporter (TC 2.A.49) family, Rh subfamily
  • 組織特異性:
    Expressed in brain, testis, placenta, pancreas, esophagus and prostate. Expressed in squamous epithelial tissues (at protein level). According to PubMed:11062476, specifically expressed in kidney.
  • 數(shù)據(jù)庫鏈接:

    HGNC: 18140

    OMIM: 605381

    KEGG: hsa:51458

    STRING: 9606.ENSP00000268122

    UniGene: Hs.459284



主站蜘蛛池模板: 人妻久久久一区二区三区 | 成人午夜精品无码一区二区三区| 国产欧美一区二区精品久久久| 久久综合九色综合久99| 中文字幕无码不卡一区二区三区| 色悠久久久久综合欧美99| 亚洲中文字幕久久精品无码va| 国产成人美女视频网站| 中文字幕aⅴ在线视频| 中文字幕人成乱码熟女| 精品无码久久久久国产动漫3d| 狠狠亚洲色一日本高清色| 露脸内射熟女--69xx| 熟妇人妻一区二区三区四区| 色悠久久久久久久综合网伊人| 国产成人啪精品视频免费网站软件 | 欧美第一黄网免费网站| 又湿又紧又大又爽又a视频| 综合欧美日韩国产成人| 久久久精品人妻无码专区不卡| 天天天欲色欲色www免费| 色欲天天婬色婬香综合网完整| 日产精品卡2卡三卡乱码网址| 国产精品午夜无码av体验区| 久久人妻无码中文字幕| 被技师按摩到高潮的少妇| 人人妻人人澡av天堂香蕉| 国产精品久久久久野外| 亚洲高清成人av电影网站| 久久不见久久见免费视频观看| 免费做a爰片久久毛片a片| 真人抽搐一进一出gif| 国产在线拍揄自揄视频导航| 717影院理论午夜伦八戒| 无码熟妇人妻av| 无码专区—va亚洲v专区vr| 九九久久精品国产免费看小说| 午夜福利三级理论电影| 激情亚洲一区国产精品| 亚洲欧美日韩在线资源观看| 日韩在线成年视频人网站观看|